Table of Contents

Articles

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  Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular β4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating

  Gareth T. Young, Lisa M. Broad, Ruud Zwart, Peter C. Astles, Michael Bodkin, Emanuele Sher and Neil S. Millar

  Molecular Pharmacology February 2007, 71 (2) 389-397; DOI: https://doi.org/10.1124/mol.106.030809
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  Sulfonylureas and Glinides Exhibit Peroxisome Proliferator-Activated Receptor γ Activity: A Combined Virtual Screening and Biological Assay Approach

  Marco Scarsi, Michael Podvinec, Adrian Roth, Hubert Hug, Sander Kersten, Hugo Albrecht, Torsten Schwede, Urs A. Meyer and Christoph Rücker

  Molecular Pharmacology February 2007, 71 (2) 398-406; DOI: https://doi.org/10.1124/mol.106.024596
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  Acetaminophen Recruits Spinal p42/p44 MAPKs and GH/IGF-1 Receptors to Produce Analgesia via the Serotonergic System

  Jérôme Bonnefont, Laurence Daulhac, Monique Etienne, Eric Chapuy, Christophe Mallet, Lemlih Ouchchane, Christiane Deval, Jean-Philippe Courade, Marc Ferrara, Alain Eschalier and Eric Clottes

  Molecular Pharmacology February 2007, 71 (2) 407-415; DOI: https://doi.org/10.1124/mol.106.025775
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  Genomic Screening in Vivo Reveals the Role Played by Vacuolar H⁺ ATPase and Cytosolic Acidification in Sensitivity to DNA-Damaging Agents Such as Cisplatin

  Chunyan Liao, Bin Hu, Matthew J. Arno and Barry Panaretou

  Molecular Pharmacology February 2007, 71 (2) 416-425; DOI: https://doi.org/10.1124/mol.106.030494
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  The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from “Indian Winter Cherry”

  Huanjie Yang, Guoqing Shi and Q. Ping Dou

  Molecular Pharmacology February 2007, 71 (2) 426-437; DOI: https://doi.org/10.1124/mol.106.030015
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  RanGAP-Mediated Nuclear Protein Import in Vascular Smooth Muscle Cells Is Augmented by Lysophosphatidylcholine

  Randolph S. Faustino, Lyle N. W. Stronger, Melanie N. Richard, Michael P. Czubryt, David A. Ford, Michele A. Prociuk, Elena Dibrov and Grant N. Pierce

  Molecular Pharmacology February 2007, 71 (2) 438-445; DOI: https://doi.org/10.1124/mol.105.021667
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  Analysis of In Vivo Nuclear Factor-κB Activation during Liver Inflammation in Mice: Prevention by Catalase Delivery

  Kenji Hyoudou, Makiya Nishikawa, Yuki Kobayashi, Yukari Kuramoto, Fumiyoshi Yamashita and Mitsuru Hashida

  Molecular Pharmacology February 2007, 71 (2) 446-453; DOI: https://doi.org/10.1124/mol.106.027169
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  Nordihydroguaiaretic Acid Affects Multiple Dynein-Dynactin Functions in Interphase and Mitotic Cells

  Kohei Arasaki, Katsuko Tani, Tamotsu Yoshimori, David J. Stephens and Mitsuo Tagaya

  Molecular Pharmacology February 2007, 71 (2) 454-460; DOI: https://doi.org/10.1124/mol.106.029611
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  Ethanol Modulates the Interaction of the Endogenous Neurosteroid Allopregnanolone with the α1β2γ2L GABA_A Receptor

  Gustav Akk, Ping Li, Brad D. Manion, Alex S. Evers and Joe Henry Steinbach

  Molecular Pharmacology February 2007, 71 (2) 461-472; DOI: https://doi.org/10.1124/mol.106.029942
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  The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor

  Armelle-Natsuo Takeda, Grégory M. Pinon, Marcelle Bens, Jérôme Fagart, Marie-Edith Rafestin-Oblin and Alain Vandewalle

  Molecular Pharmacology February 2007, 71 (2) 473-482; DOI: https://doi.org/10.1124/mol.106.031112
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  Agonist-, Antagonist-, and Benzodiazepine-Induced Structural Changes in the α₁ Met¹¹³-Leu¹³² Region of the GABA_A Receptor

  Jessica Holden Kloda and Cynthia Czajkowski

  Molecular Pharmacology February 2007, 71 (2) 483-493; DOI: https://doi.org/10.1124/mol.106.028662
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  Kinins Promote B₂ Receptor Endocytosis and Delay Constitutive B₁ Receptor Endocytosis

  Johan Enquist, Carl Skröder, Jennifer L. Whistler and L.M. Fredrik Leeb-Lundberg

  Molecular Pharmacology February 2007, 71 (2) 494-507; DOI: https://doi.org/10.1124/mol.106.030858
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  Pharmacology and Signaling Properties of Epidermal Growth Factor Receptor Isoforms Studied by Bioluminescence Resonance Energy Transfer

  Hans H. Schiffer, Esther C. Reding, Stephen R. Fuhs, Qing Lu, Fabrice Piu, Steven Wong, Pey-Lih H. Littler, Dave M. Weiner, William Keefe, Phil K. Tan, Norman R. Nash, Anne E. Knapp, Roger Olsson and Mark R. Brann

  Molecular Pharmacology February 2007, 71 (2) 508-518; DOI: https://doi.org/10.1124/mol.106.027656
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  Involvement of Dopamine System in Regulation of Na⁺,K⁺-ATPase in the Striatum upon Activation of Opioid Receptors by Morphine

  Zhao-Qiu Wu, Jie Chen, Zhi-Qiang Chi and Jing-Gen Liu

  Molecular Pharmacology February 2007, 71 (2) 519-530; DOI: https://doi.org/10.1124/mol.106.029561
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  Stabilization of Cellular mRNAs and Up-Regulation of Proteins by Oligoribonucleotides Homologous to the Bcl2 Adenine-Uridine Rich Element Motif

  Annamaria Bevilacqua, Laura Ghisolfi, Sara Franzi, Giovanna Maresca, Roberto Gherzi, Sergio Capaccioli, Angelo Nicolin and Gianfranco Canti

  Molecular Pharmacology February 2007, 71 (2) 531-538; DOI: https://doi.org/10.1124/mol.106.029041
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  Tonically Active GABA_A Receptors in Hippocampal Pyramidal Neurons Exhibit Constitutive GABA-Independent Gating

  Melissa R. McCartney, Tarek Z. Deeb, Tricia N. Henderson and Tim G. Hales

  Molecular Pharmacology February 2007, 71 (2) 539-548; DOI: https://doi.org/10.1124/mol.106.028597
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  An Opioid Agonist that Does Not Induce μ-Opioid Receptor—Arrestin Interactions or Receptor Internalization

  C. E. Groer, K. Tidgewell, R. A. Moyer, W. W. Harding, R. B. Rothman, T. E. Prisinzano and L. M. Bohn

  Molecular Pharmacology February 2007, 71 (2) 549-557; DOI: https://doi.org/10.1124/mol.106.028258
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  1,1-Bis(3′-Indolyl)-1-(p-substitutedphenyl)methanes Inhibit Growth, Induce Apoptosis, and Decrease the Androgen Receptor in LNCaP Prostate Cancer Cells through Peroxisome Proliferator-Activated Receptor γ-Independent Pathways

  Sudhakar Chintharlapalli, Sabitha Papineni and Stephen Safe

  Molecular Pharmacology February 2007, 71 (2) 558-569; DOI: https://doi.org/10.1124/mol.106.028696
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  2-Aminoethoxydiphenyl Borate Directly Inhibits Channels Composed of Connexin26 and/or Connexin32

  Liang Tao and Andrew L. Harris

  Molecular Pharmacology February 2007, 71 (2) 570-579; DOI: https://doi.org/10.1124/mol.106.027508
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  Nefiracetam Potentiates N-Methyl-d-aspartate (NMDA) Receptor Function via Protein Kinase C Activation and Reduces Magnesium Block of NMDA Receptor

  Shigeki Moriguchi, Norifumi Shioda, Hiroshi Maejima, Xilong Zhao, William Marszalec, Jay Z. Yeh, Kohji Fukunaga and Toshio Narahashi

  Molecular Pharmacology February 2007, 71 (2) 580-587; DOI: https://doi.org/10.1124/mol.106.027607
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  Unnatural Amino Acid-Substituted (Hydroxyethyl)urea Peptidomimetics Inhibit γ-Secretase and Promote the Neuronal Differentiation of Neuroblastoma Cells

  Yung-Feng Liao, Bo-Jeng Wang, Wen-Ming Hsu, Hsinyu Lee, Chia-Yin Liao, Shin-Ying Wu, Hui-Ting Cheng and Ming-Kuan Hu

  Molecular Pharmacology February 2007, 71 (2) 588-601; DOI: https://doi.org/10.1124/mol.106.024299
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  A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure

  Satoshi Mashiko, Akane Ishihara, Hisashi Iwaasa, Hideki Sano, Junko Ito, Akira Gomori, Zenjun Oda, Ryuichi Moriya, Hiroko Matsushita, Makoto Jitsuoka, Osamu Okamoto, Douglas J. MacNeil, Lex H. T. Van der Ploeg, Takehiro Fukami and Akio Kanatani

  Molecular Pharmacology February 2007, 71 (2) 602-608; DOI: https://doi.org/10.1124/mol.106.029991
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  Inhibition of Tumor Necrosis Factor-α-Inducible Inflammatory Genes by Interferon-γ Is Associated with Altered Nuclear Factor-κB Transactivation and Enhanced Histone Deacetylase Activity

  Stefan Keslacy, Omar Tliba, Hasna Baidouri and Yassine Amrani

  Molecular Pharmacology February 2007, 71 (2) 609-618; DOI: https://doi.org/10.1124/mol.106.030171
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  Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir

  Tomoki Imaoka, Hiroyuki Kusuhara, Masashi Adachi, John D. Schuetz, Kenji Takeuchi and Yuichi Sugiyama

  Molecular Pharmacology February 2007, 71 (2) 619-627; DOI: https://doi.org/10.1124/mol.106.028233
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  Imino Sugars Are Potent Agonists of the Human Glucose Sensor SGLT3

  Andrew A. Voss, Ana Díez-Sampedro, Bruce A. Hirayama, Donald D. F. Loo and Ernest M. Wright

  Molecular Pharmacology February 2007, 71 (2) 628-634; DOI: https://doi.org/10.1124/mol.106.030288