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Research ArticleArticle

Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular β4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating

Gareth T. Young, Lisa M. Broad, Ruud Zwart, Peter C. Astles, Michael Bodkin, Emanuele Sher and Neil S. Millar
Molecular Pharmacology February 2007, 71 (2) 389-397; DOI: https://doi.org/10.1124/mol.106.030809

Article Information

vol. 71 no. 2 389-397
DOI 
https://doi.org/10.1124/mol.106.030809
PubMed 
17065235
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 12, 2006
  • Accepted October 25, 2006
  • Published online January 19, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gareth T. Young,
  2. Lisa M. Broad,
  3. Ruud Zwart,
  4. Peter C. Astles,
  5. Michael Bodkin,
  6. Emanuele Sher and
  7. Neil S. Millar
  1. Department of Pharmacology, University College London, Gower Street, London, United Kingdom (G.T.Y., N.S.M.); and Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (L.M.B., R.Z., P.C.A., M.B., E.S.)
  1. Address correspondence to:
    Dr. Neil S. Millar, Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK. E-mail: n.millar{at}ucl.ac.uk
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Research ArticleArticle

Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular β4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating

Gareth T. Young, Lisa M. Broad, Ruud Zwart, Peter C. Astles, Michael Bodkin, Emanuele Sher and Neil S. Millar
Molecular Pharmacology February 1, 2007, 71 (2) 389-397; DOI: https://doi.org/10.1124/mol.106.030809
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