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Molecular Pharmacology

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Table of Contents

March 01, 2007; Volume 71,Issue 3

Perspective

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    DNA (Cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic Agent for Schizophrenia
    Jonathan M. Levenson
    Molecular Pharmacology March 2007, 71 (3) 635-637; DOI: https://doi.org/10.1124/mol.106.033266

Accelerated Communication

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    Native Rat Hippocampal 5-HT1A Receptors Show Constitutive Activity
    Jean-Claude Martel, Anne-Marie Ormière, Nathalie Leduc, Marie-Bernadette Assié, Didier Cussac and Adrian Newman-Tancredi
    Molecular Pharmacology March 2007, 71 (3) 638-643; DOI: https://doi.org/10.1124/mol.106.029769

Articles

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    DNA Methyltransferase Inhibitors Coordinately Induce Expression of the Human Reelin and Glutamic Acid Decarboxylase 67 Genes
    Marija Kundakovic, Ying Chen, Erminio Costa and Dennis R. Grayson
    Molecular Pharmacology March 2007, 71 (3) 644-653; DOI: https://doi.org/10.1124/mol.106.030635
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    Inhibition of the c-Jun N-Terminal Kinase-Mediated Mitochondrial Cell Death Pathway Restores Auditory Function in Sound-Exposed Animals
    Jing Wang, Jérôme Ruel, Sabine Ladrech, Christophe Bonny, Thomas R. van de Water and Jean-Luc Puel
    Molecular Pharmacology March 2007, 71 (3) 654-666; DOI: https://doi.org/10.1124/mol.106.028936
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    Tumor Necrosis Factor α and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier
    Björn Bauer, Anika M. S. Hartz and David S. Miller
    Molecular Pharmacology March 2007, 71 (3) 667-675; DOI: https://doi.org/10.1124/mol.106.029512
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    Isolation and Structure-Activity of μ-Conotoxin TIIIA, A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels
    Richard J. Lewis, Christina I. Schroeder, Jenny Ekberg, Katherine J. Nielsen, Marion Loughnan, Linda Thomas, Denise A. Adams, Roger Drinkwater, David J. Adams and Paul F. Alewood
    Molecular Pharmacology March 2007, 71 (3) 676-685; DOI: https://doi.org/10.1124/mol.106.028225
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    Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway
    Michael Holinstat, Bryan Voss, Matthew L. Bilodeau and Heidi E. Hamm
    Molecular Pharmacology March 2007, 71 (3) 686-694; DOI: https://doi.org/10.1124/mol.106.029371
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    The Nucleotide Analog Cidofovir Suppresses Basic Fibroblast Growth Factor (FGF2) Expression and Signaling and Induces Apoptosis in FGF2-Overexpressing Endothelial Cells
    Sandra Liekens, Sofie Gijsbers, Els Vanstreels, Dirk Daelemans, Erik De Clercq and Sigrid Hatse
    Molecular Pharmacology March 2007, 71 (3) 695-703; DOI: https://doi.org/10.1124/mol.106.026559
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    Amino-Pyrrolidine Tricarboxylic Acids Give New Insight into Group III Metabotropic Glutamate Receptor Activation Mechanism
    Mélanie Frauli, Nadia Hubert, Stephan Schann, Nicolas Triballeau, Hugues-Olivier Bertrand, Francine Acher, Pascal Neuville, Jean-Philippe Pin and Laurent Prézeau
    Molecular Pharmacology March 2007, 71 (3) 704-712; DOI: https://doi.org/10.1124/mol.106.030254
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    Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds
    Randy M. Wadkins, Janice L. Hyatt, Carol C. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Craig E. Wheelock, Paul D. Jones, Bruce D. Hammock and Philip M. Potter
    Molecular Pharmacology March 2007, 71 (3) 713-723; DOI: https://doi.org/10.1124/mol.105.021683
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    Identification of Leu276 of the S1P1 Receptor and Phe263 of the S1P3 Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies
    Qiaolin Deng, Joseph A. Clemas, Gary Chrebet, Paul Fischer, Jeffrey J. Hale, Zhen Li, Sander G. Mills, James Bergstrom, Suzanne Mandala, Ralph Mosley and Stephen A. Parent
    Molecular Pharmacology March 2007, 71 (3) 724-735; DOI: https://doi.org/10.1124/mol.106.029223
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    Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate
    M. Gomez-Lazaro, M. F. Galindo, R. M. Melero-Fernandez de Mera, F. J. Fernandez-Gómez, C. G. Concannon, M. F. Segura, J. X. Comella, J. H. M. Prehn and J. Jordan
    Molecular Pharmacology March 2007, 71 (3) 736-743; DOI: https://doi.org/10.1124/mol.106.030718
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    Benzo[a]pyrene-7,8-dihydrodiol Promotes Checkpoint Activation and G2/M Arrest in Human Bronchoalveolar Carcinoma H358 Cells
    M. Cecilia Caino, Jose L. Oliva, Hao Jiang, Trevor M. Penning and Marcelo G. Kazanietz
    Molecular Pharmacology March 2007, 71 (3) 744-750; DOI: https://doi.org/10.1124/mol.106.032078
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    Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones
    Ying Wang, Tip W. Loo, M. Claire Bartlett and David M. Clarke
    Molecular Pharmacology March 2007, 71 (3) 751-758; DOI: https://doi.org/10.1124/mol.106.029926
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    Mutational Disruption of a Conserved Disulfide Bond in Muscarinic Acetylcholine Receptors Attenuates Positive Homotropic Cooperativity between Multiple Allosteric Sites and Has Subtype-Dependent Effects on the Affinities of Muscarinic Allosteric Ligands
    Xi-Ping Huang and John Ellis
    Molecular Pharmacology March 2007, 71 (3) 759-768; DOI: https://doi.org/10.1124/mol.106.028944
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    Ca2+ Permeability of the (α4)3(β2)2 Stoichiometry Greatly Exceeds That of (α4)2(β2)3 Human Acetylcholine Receptors
    L. Tapia, A. Kuryatov and J. Lindstrom
    Molecular Pharmacology March 2007, 71 (3) 769-776; DOI: https://doi.org/10.1124/mol.106.030445
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    Novel G423S Mutation of Human α7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism
    Hiroshi Tsuneki, Soushi Kobayashi, Kazue Takagi, Syota Kagawa, Masahiko Tsunoda, Masahiko Murata, Tadasu Matsuoka, Tsutomu Wada, Masayoshi Kurachi, Ikuko Kimura and Toshiyasu Sasaoka
    Molecular Pharmacology March 2007, 71 (3) 777-786; DOI: https://doi.org/10.1124/mol.106.030866
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    Pioglitazone Inhibits Androgen Production in NCI-H295R Cells by Regulating Gene Expression of CYP17 and HSD3B2
    Petra Kempná, Gaby Hofer, Primus E. Mullis and Christa E. Flück
    Molecular Pharmacology March 2007, 71 (3) 787-798; DOI: https://doi.org/10.1124/mol.106.028902
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    Evidence for Direct Regulation of Myocardial Na+/H+ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel and Specific RSK Inhibitor fmk on Responses to α1-Adrenergic Stimulation
    Friederike Cuello, Andrew K. Snabaitis, Michael S. Cohen, Jack Taunton and Metin Avkiran
    Molecular Pharmacology March 2007, 71 (3) 799-806; DOI: https://doi.org/10.1124/mol.106.029900
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    Transcriptional Regulation of Human CYP2A13 Expression in the Respiratory Tract by CCAAT/Enhancer Binding Protein and Epigenetic Modulation
    Guoyu Ling, Yuan Wei and Xinxin Ding
    Molecular Pharmacology March 2007, 71 (3) 807-816; DOI: https://doi.org/10.1124/mol.106.031104
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    Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice
    Yuji Tanaka, Jonathan M. Maher, Chuan Chen and Curtis D. Klaassen
    Molecular Pharmacology March 2007, 71 (3) 817-825; DOI: https://doi.org/10.1124/mol.106.029033
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    Characterization and Comparison of Nicotine and Cotinine Metabolism in Vitro and in Vivo in DBA/2 and C57BL/6 Mice
    Eric C. K. Siu and Rachel F. Tyndale
    Molecular Pharmacology March 2007, 71 (3) 826-834; DOI: https://doi.org/10.1124/mol.106.032086
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    Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca2+/Calmodulin-Dependent Kinase II-Dependent Mechanism
    Y. Wei, J. M. Williams, C. Dipace, U. Sung, J. A. Javitch, A. Galli and C. Saunders
    Molecular Pharmacology March 2007, 71 (3) 835-842; DOI: https://doi.org/10.1124/mol.106.026351
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    The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells
    Guyllaume Coiret, Anne-Sophie Borowiec, Pascal Mariot, Halima Ouadid-Ahidouch and Fabrice Matifat
    Molecular Pharmacology March 2007, 71 (3) 843-851; DOI: https://doi.org/10.1124/mol.106.028290
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    Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital
    Anja Zeller, Margarete Arras, Rachel Jurd and Uwe Rudolph
    Molecular Pharmacology March 2007, 71 (3) 852-859; DOI: https://doi.org/10.1124/mol.106.030049
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    Up-Regulation of 150-kDa Oxygen-Regulated Protein by Celecoxib in Human Gastric Carcinoma Cells
    Takushi Namba, Tatsuya Hoshino, Ken-ichiro Tanaka, Shinji Tsutsumi, Tomoaki Ishihara, Shinji Mima, Keitarou Suzuki, Satoshi Ogawa and Tohru Mizushima
    Molecular Pharmacology March 2007, 71 (3) 860-870; DOI: https://doi.org/10.1124/mol.106.027698
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    4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est–Like Protein-1-Activating Protein-1 Signal Transduction
    Brante P. Sampey, David L. Carbone, Jonathan A. Doorn, Derek A. Drechsel and Dennis R. Petersen
    Molecular Pharmacology March 2007, 71 (3) 871-883; DOI: https://doi.org/10.1124/mol.106.029686
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    The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone Behavior
    J. A. Shimshoni, E. C. Dalton, A. Jenkins, S. Eyal, K. Ewan, R. S. B. Williams, N. Pessah, B. Yagen, A. J. Harwood and M. Bialer
    Molecular Pharmacology March 2007, 71 (3) 884-892; DOI: https://doi.org/10.1124/mol.106.030601
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    Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking Assays
    Allison A. Johnson, Christophe Marchand, Sachindra S. Patil, Roberta Costi, Roberto Di Santo, Terrence R. Burke and Yves Pommier
    Molecular Pharmacology March 2007, 71 (3) 893-901; DOI: https://doi.org/10.1124/mol.106.030817
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    Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition
    Gaochao Tian, Dee Wilkins and Clay W. Scott
    Molecular Pharmacology March 2007, 71 (3) 902-911; DOI: https://doi.org/10.1124/mol.106.029868
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    Essential Role for Class II Phosphoinositide 3-kinase α-Isoform in Ca2+-Induced, Rho- and Rho Kinase-Dependent Regulation of Myosin Phosphatase and Contraction in Isolated Vascular Smooth Muscle Cells
    Kazuaki Yoshioka, Naotoshi Sugimoto, Noriko Takuwa and Yoh Takuwa
    Molecular Pharmacology March 2007, 71 (3) 912-920; DOI: https://doi.org/10.1124/mol.106.032599
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    Molecular Interactions Underlying the Unusually High Adenosine Affinity of a Novel Trypanosoma brucei Nucleoside Transporter
    Mohammed I. Al-Salabi, Lynsey J. M. Wallace, Alexandra Lüscher, Pascal Mäser, Denise Candlish, Boris Rodenko, Matthew K. Gould, Ishrat Jabeen, Sreekantan N. Ajith and Harry P. de Koning
    Molecular Pharmacology March 2007, 71 (3) 921-929; DOI: https://doi.org/10.1124/mol.106.031559
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    Activation of the CXCR3 Chemokine Receptor through Anchoring of a Small Molecule Chelator Ligand between TM-III, -IV, and -VI
    Mette M. Rosenkilde, Michael B. Andersen, Rie Nygaard, Thomas M. Frimurer and Thue W. Schwartz
    Molecular Pharmacology March 2007, 71 (3) 930-941; DOI: https://doi.org/10.1124/mol.106.030031
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    ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1α (HIF-1α) Binding and Mediates HIF-1α Expression by Bafilomycin A1
    Ji-Hong Lim, Jong-Wan Park, Sung Joon Kim, Myung-Suk Kim, Sang-Ki Park, Randall S. Johnson and Yang-Sook Chun
    Molecular Pharmacology March 2007, 71 (3) 942-948; DOI: https://doi.org/10.1124/mol.106.030296
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    Role of Nuclear Factor-κB and Protein Kinase C Signaling in the Expression of the Kinin B1 Receptor in Human Vascular Smooth Muscle Cells
    Marie Eve Moreau, Marie-Thérèse Bawolak, Guillaume Morissette, Albert Adam and François Marceau
    Molecular Pharmacology March 2007, 71 (3) 949-956; DOI: https://doi.org/10.1124/mol.106.030684
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Molecular Pharmacology: 71 (3)
Molecular Pharmacology
Vol. 71, Issue 3
1 Mar 2007
  • Table of Contents
  • Table of Contents (PDF)
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  • Back Matter (PDF)
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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