Table of Contents

Articles

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  DNA Methyltransferase Inhibitors Coordinately Induce Expression of the Human Reelin and Glutamic Acid Decarboxylase 67 Genes

  Marija Kundakovic, Ying Chen, Erminio Costa and Dennis R. Grayson

  Molecular Pharmacology March 2007, 71 (3) 644-653; DOI: https://doi.org/10.1124/mol.106.030635
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  Inhibition of the c-Jun N-Terminal Kinase-Mediated Mitochondrial Cell Death Pathway Restores Auditory Function in Sound-Exposed Animals

  Jing Wang, Jérôme Ruel, Sabine Ladrech, Christophe Bonny, Thomas R. van de Water and Jean-Luc Puel

  Molecular Pharmacology March 2007, 71 (3) 654-666; DOI: https://doi.org/10.1124/mol.106.028936
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  Tumor Necrosis Factor α and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier

  Björn Bauer, Anika M. S. Hartz and David S. Miller

  Molecular Pharmacology March 2007, 71 (3) 667-675; DOI: https://doi.org/10.1124/mol.106.029512
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  Isolation and Structure-Activity of μ-Conotoxin TIIIA, A Potent Inhibitor of Tetrodotoxin-Sensitive Voltage-Gated Sodium Channels

  Richard J. Lewis, Christina I. Schroeder, Jenny Ekberg, Katherine J. Nielsen, Marion Loughnan, Linda Thomas, Denise A. Adams, Roger Drinkwater, David J. Adams and Paul F. Alewood

  Molecular Pharmacology March 2007, 71 (3) 676-685; DOI: https://doi.org/10.1124/mol.106.028225
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  Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway

  Michael Holinstat, Bryan Voss, Matthew L. Bilodeau and Heidi E. Hamm

  Molecular Pharmacology March 2007, 71 (3) 686-694; DOI: https://doi.org/10.1124/mol.106.029371
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  The Nucleotide Analog Cidofovir Suppresses Basic Fibroblast Growth Factor (FGF2) Expression and Signaling and Induces Apoptosis in FGF2-Overexpressing Endothelial Cells

  Sandra Liekens, Sofie Gijsbers, Els Vanstreels, Dirk Daelemans, Erik De Clercq and Sigrid Hatse

  Molecular Pharmacology March 2007, 71 (3) 695-703; DOI: https://doi.org/10.1124/mol.106.026559
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  Amino-Pyrrolidine Tricarboxylic Acids Give New Insight into Group III Metabotropic Glutamate Receptor Activation Mechanism

  Mélanie Frauli, Nadia Hubert, Stephan Schann, Nicolas Triballeau, Hugues-Olivier Bertrand, Francine Acher, Pascal Neuville, Jean-Philippe Pin and Laurent Prézeau

  Molecular Pharmacology March 2007, 71 (3) 704-712; DOI: https://doi.org/10.1124/mol.106.030254
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  Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds

  Randy M. Wadkins, Janice L. Hyatt, Carol C. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Craig E. Wheelock, Paul D. Jones, Bruce D. Hammock and Philip M. Potter

  Molecular Pharmacology March 2007, 71 (3) 713-723; DOI: https://doi.org/10.1124/mol.105.021683
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  Identification of Leu276 of the S1P₁ Receptor and Phe263 of the S1P₃ Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies

  Qiaolin Deng, Joseph A. Clemas, Gary Chrebet, Paul Fischer, Jeffrey J. Hale, Zhen Li, Sander G. Mills, James Bergstrom, Suzanne Mandala, Ralph Mosley and Stephen A. Parent

  Molecular Pharmacology March 2007, 71 (3) 724-735; DOI: https://doi.org/10.1124/mol.106.029223
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  Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate

  M. Gomez-Lazaro, M. F. Galindo, R. M. Melero-Fernandez de Mera, F. J. Fernandez-Gómez, C. G. Concannon, M. F. Segura, J. X. Comella, J. H. M. Prehn and J. Jordan

  Molecular Pharmacology March 2007, 71 (3) 736-743; DOI: https://doi.org/10.1124/mol.106.030718
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  Benzo[a]pyrene-7,8-dihydrodiol Promotes Checkpoint Activation and G₂/M Arrest in Human Bronchoalveolar Carcinoma H358 Cells

  M. Cecilia Caino, Jose L. Oliva, Hao Jiang, Trevor M. Penning and Marcelo G. Kazanietz

  Molecular Pharmacology March 2007, 71 (3) 744-750; DOI: https://doi.org/10.1124/mol.106.032078
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  Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones

  Ying Wang, Tip W. Loo, M. Claire Bartlett and David M. Clarke

  Molecular Pharmacology March 2007, 71 (3) 751-758; DOI: https://doi.org/10.1124/mol.106.029926
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  Mutational Disruption of a Conserved Disulfide Bond in Muscarinic Acetylcholine Receptors Attenuates Positive Homotropic Cooperativity between Multiple Allosteric Sites and Has Subtype-Dependent Effects on the Affinities of Muscarinic Allosteric Ligands

  Xi-Ping Huang and John Ellis

  Molecular Pharmacology March 2007, 71 (3) 759-768; DOI: https://doi.org/10.1124/mol.106.028944
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  Ca²⁺ Permeability of the (α4)₃(β2)₂ Stoichiometry Greatly Exceeds That of (α4)₂(β2)₃ Human Acetylcholine Receptors

  L. Tapia, A. Kuryatov and J. Lindstrom

  Molecular Pharmacology March 2007, 71 (3) 769-776; DOI: https://doi.org/10.1124/mol.106.030445
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  Novel G423S Mutation of Human α7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism

  Hiroshi Tsuneki, Soushi Kobayashi, Kazue Takagi, Syota Kagawa, Masahiko Tsunoda, Masahiko Murata, Tadasu Matsuoka, Tsutomu Wada, Masayoshi Kurachi, Ikuko Kimura and Toshiyasu Sasaoka

  Molecular Pharmacology March 2007, 71 (3) 777-786; DOI: https://doi.org/10.1124/mol.106.030866
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  Pioglitazone Inhibits Androgen Production in NCI-H295R Cells by Regulating Gene Expression of CYP17 and HSD3B2

  Petra Kempná, Gaby Hofer, Primus E. Mullis and Christa E. Flück

  Molecular Pharmacology March 2007, 71 (3) 787-798; DOI: https://doi.org/10.1124/mol.106.028902
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  Evidence for Direct Regulation of Myocardial Na⁺/H⁺ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel and Specific RSK Inhibitor fmk on Responses to α₁-Adrenergic Stimulation

  Friederike Cuello, Andrew K. Snabaitis, Michael S. Cohen, Jack Taunton and Metin Avkiran

  Molecular Pharmacology March 2007, 71 (3) 799-806; DOI: https://doi.org/10.1124/mol.106.029900
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  Transcriptional Regulation of Human CYP2A13 Expression in the Respiratory Tract by CCAAT/Enhancer Binding Protein and Epigenetic Modulation

  Guoyu Ling, Yuan Wei and Xinxin Ding

  Molecular Pharmacology March 2007, 71 (3) 807-816; DOI: https://doi.org/10.1124/mol.106.031104
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  Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice

  Yuji Tanaka, Jonathan M. Maher, Chuan Chen and Curtis D. Klaassen

  Molecular Pharmacology March 2007, 71 (3) 817-825; DOI: https://doi.org/10.1124/mol.106.029033
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  Characterization and Comparison of Nicotine and Cotinine Metabolism in Vitro and in Vivo in DBA/2 and C57BL/6 Mice

  Eric C. K. Siu and Rachel F. Tyndale

  Molecular Pharmacology March 2007, 71 (3) 826-834; DOI: https://doi.org/10.1124/mol.106.032086
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  Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca²⁺/Calmodulin-Dependent Kinase II-Dependent Mechanism

  Y. Wei, J. M. Williams, C. Dipace, U. Sung, J. A. Javitch, A. Galli and C. Saunders

  Molecular Pharmacology March 2007, 71 (3) 835-842; DOI: https://doi.org/10.1124/mol.106.026351
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  The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells

  Guyllaume Coiret, Anne-Sophie Borowiec, Pascal Mariot, Halima Ouadid-Ahidouch and Fabrice Matifat

  Molecular Pharmacology March 2007, 71 (3) 843-851; DOI: https://doi.org/10.1124/mol.106.028290
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  Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital

  Anja Zeller, Margarete Arras, Rachel Jurd and Uwe Rudolph

  Molecular Pharmacology March 2007, 71 (3) 852-859; DOI: https://doi.org/10.1124/mol.106.030049
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  Up-Regulation of 150-kDa Oxygen-Regulated Protein by Celecoxib in Human Gastric Carcinoma Cells

  Takushi Namba, Tatsuya Hoshino, Ken-ichiro Tanaka, Shinji Tsutsumi, Tomoaki Ishihara, Shinji Mima, Keitarou Suzuki, Satoshi Ogawa and Tohru Mizushima

  Molecular Pharmacology March 2007, 71 (3) 860-870; DOI: https://doi.org/10.1124/mol.106.027698
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  4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est–Like Protein-1-Activating Protein-1 Signal Transduction

  Brante P. Sampey, David L. Carbone, Jonathan A. Doorn, Derek A. Drechsel and Dennis R. Petersen

  Molecular Pharmacology March 2007, 71 (3) 871-883; DOI: https://doi.org/10.1124/mol.106.029686
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  The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone Behavior

  J. A. Shimshoni, E. C. Dalton, A. Jenkins, S. Eyal, K. Ewan, R. S. B. Williams, N. Pessah, B. Yagen, A. J. Harwood and M. Bialer

  Molecular Pharmacology March 2007, 71 (3) 884-892; DOI: https://doi.org/10.1124/mol.106.030601
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  Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking Assays

  Allison A. Johnson, Christophe Marchand, Sachindra S. Patil, Roberta Costi, Roberto Di Santo, Terrence R. Burke and Yves Pommier

  Molecular Pharmacology March 2007, 71 (3) 893-901; DOI: https://doi.org/10.1124/mol.106.030817
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  Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca²⁺ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition

  Gaochao Tian, Dee Wilkins and Clay W. Scott

  Molecular Pharmacology March 2007, 71 (3) 902-911; DOI: https://doi.org/10.1124/mol.106.029868
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  Essential Role for Class II Phosphoinositide 3-kinase α-Isoform in Ca²⁺-Induced, Rho- and Rho Kinase-Dependent Regulation of Myosin Phosphatase and Contraction in Isolated Vascular Smooth Muscle Cells

  Kazuaki Yoshioka, Naotoshi Sugimoto, Noriko Takuwa and Yoh Takuwa

  Molecular Pharmacology March 2007, 71 (3) 912-920; DOI: https://doi.org/10.1124/mol.106.032599
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  Molecular Interactions Underlying the Unusually High Adenosine Affinity of a Novel Trypanosoma brucei Nucleoside Transporter

  Mohammed I. Al-Salabi, Lynsey J. M. Wallace, Alexandra Lüscher, Pascal Mäser, Denise Candlish, Boris Rodenko, Matthew K. Gould, Ishrat Jabeen, Sreekantan N. Ajith and Harry P. de Koning

  Molecular Pharmacology March 2007, 71 (3) 921-929; DOI: https://doi.org/10.1124/mol.106.031559
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  Activation of the CXCR3 Chemokine Receptor through Anchoring of a Small Molecule Chelator Ligand between TM-III, -IV, and -VI

  Mette M. Rosenkilde, Michael B. Andersen, Rie Nygaard, Thomas M. Frimurer and Thue W. Schwartz

  Molecular Pharmacology March 2007, 71 (3) 930-941; DOI: https://doi.org/10.1124/mol.106.030031
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  ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1α (HIF-1α) Binding and Mediates HIF-1α Expression by Bafilomycin A1

  Ji-Hong Lim, Jong-Wan Park, Sung Joon Kim, Myung-Suk Kim, Sang-Ki Park, Randall S. Johnson and Yang-Sook Chun

  Molecular Pharmacology March 2007, 71 (3) 942-948; DOI: https://doi.org/10.1124/mol.106.030296
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  Role of Nuclear Factor-κB and Protein Kinase C Signaling in the Expression of the Kinin B₁ Receptor in Human Vascular Smooth Muscle Cells

  Marie Eve Moreau, Marie-Thérèse Bawolak, Guillaume Morissette, Albert Adam and François Marceau

  Molecular Pharmacology March 2007, 71 (3) 949-956; DOI: https://doi.org/10.1124/mol.106.030684