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Research ArticleArticle

Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition

Gaochao Tian, Dee Wilkins and Clay W. Scott
Molecular Pharmacology March 2007, 71 (3) 902-911; DOI: https://doi.org/10.1124/mol.106.029868

Article Information

vol. 71 no. 3 902-911
DOI 
https://doi.org/10.1124/mol.106.029868
PubMed 
17172464
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 11, 2006
  • Accepted December 15, 2006
  • Published online February 16, 2007.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gaochao Tian,
  2. Dee Wilkins and
  3. Clay W. Scott
  1. Department of Lead Generation, AstraZeneca Pharmaceuticals, Wilmington, Delaware
  1. Address correspondence to:
    Dr. Gaochao Tian, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19803. E-mail: gaochao.tian{at}astrazeneca.com
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Research ArticleArticle

Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition

Gaochao Tian, Dee Wilkins and Clay W. Scott
Molecular Pharmacology March 1, 2007, 71 (3) 902-911; DOI: https://doi.org/10.1124/mol.106.029868
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