Table of Contents

Articles

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  Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis

  Jin Hee Shin, Sung Ig Cho, Hyang Ran Lim, Jae Keun Lee, Young Ae Lee, Jai Sung Noh, In Soo Joo, Kee-Won Kim and Byoung Joo Gwag

  Molecular Pharmacology April 2007, 71 (4) 965-975; DOI: https://doi.org/10.1124/mol.106.030676
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  An Essential Role for Constitutive Endocytosis, but Not Activity, in the Axonal Targeting of the CB₁ Cannabinoid Receptor

  Neil A. McDonald, Christopher M. Henstridge, Christopher N. Connolly and Andrew J. Irving

  Molecular Pharmacology April 2007, 71 (4) 976-984; DOI: https://doi.org/10.1124/mol.106.029348
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  Genetic Evidence for a Protective Role of Heat Shock Factor 1 against Irritant-Induced Gastric Lesions

  Ken-ichiro Tanaka, Shinji Tsutsumi, Yasuhiro Arai, Tatsuya Hoshino, Keitarou Suzuki, Eiichi Takaki, Takaaki Ito, Koji Takeuchi, Akira Nakai and Tohru Mizushima

  Molecular Pharmacology April 2007, 71 (4) 985-993; DOI: https://doi.org/10.1124/mol.106.033282
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  Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[³⁵S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist

  Leigh A. Stoddart, Andrew J. Brown and Graeme Milligan

  Molecular Pharmacology April 2007, 71 (4) 994-1005; DOI: https://doi.org/10.1124/mol.106.031534
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  Differential Selection of Acridine Resistance Mutations in Human DNA Topoisomerase IIβ Is Dependent on the Acridine Structure

  Chrysoula Leontiou, Gary P. Watters, Kathryn L. Gilroy, Pauline Heslop, Ian G. Cowell, Kate Craig, Robert N. Lightowlers, Jeremy H. Lakey and Caroline A. Austin

  Molecular Pharmacology April 2007, 71 (4) 1006-1014; DOI: https://doi.org/10.1124/mol.106.032953
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  The α_1b-Adrenoceptor Exists as a Higher-Order Oligomer: Effective Oligomerization Is Required for Receptor Maturation, Surface Delivery, and Function

  Juan F. Lopez-Gimenez, Meritxell Canals, John D. Pediani and Graeme Milligan

  Molecular Pharmacology April 2007, 71 (4) 1015-1029; DOI: https://doi.org/10.1124/mol.106.033035
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  RGS4 Modulates Serotonin Signaling in Prefrontal Cortex and Links to Serotonin Dysfunction in a Rat Model of Schizophrenia

  Zhenglin Gu, Qian Jiang and Zhen Yan

  Molecular Pharmacology April 2007, 71 (4) 1030-1039; DOI: https://doi.org/10.1124/mol.106.032490
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  N-Terminal Residues Control Proteasomal Degradation of RGS2, RGS4, and RGS5 in Human Embryonic Kidney 293 Cells

  Johannes Bodenstein, Roger K. Sunahara and Richard R. Neubig

  Molecular Pharmacology April 2007, 71 (4) 1040-1050; DOI: https://doi.org/10.1124/mol.106.029397
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  BRCA1 Contributes to Cell Cycle Arrest and Chemoresistance in Response to the Anticancer Agent Irofulven

  Timothy Wiltshire, Jamie Senft, Yutian Wang, Gregory W. Konat, Sharon L. Wenger, Eddie Reed and Weixin Wang

  Molecular Pharmacology April 2007, 71 (4) 1051-1060; DOI: https://doi.org/10.1124/mol.106.029504
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  High-Throughput Screening for Small-Molecule Activators of Neutrophils: Identification of Novel N-Formyl Peptide Receptor Agonists

  Igor A. Schepetkin, Liliya N. Kirpotina, Andrei I. Khlebnikov and Mark T. Quinn

  Molecular Pharmacology April 2007, 71 (4) 1061-1074; DOI: https://doi.org/10.1124/mol.106.033100
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  Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca²⁺-Activated K⁺ Channel Activators Selective for β1 and β4 but Not for β2 Subunits

  Takashi Morimoto, Kazuho Sakamoto, Hiroko Sade, Susumu Ohya, Katsuhiko Muraki and Yuji Imaizumi

  Molecular Pharmacology April 2007, 71 (4) 1075-1088; DOI: https://doi.org/10.1124/mol.106.031146
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  Function of Both Sinusoidal and Canalicular Transporters Controls the Concentration of Organic Anions within Hepatocytes

  Corinne Planchamp, Antoine Hadengue, Bruno Stieger, Joëlle Bourquin, Alain Vonlaufen, Jean-Louis Frossard, Rafael Quadri, Christoph D. Becker and Catherine M. Pastor

  Molecular Pharmacology April 2007, 71 (4) 1089-1097; DOI: https://doi.org/10.1124/mol.106.030759
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  Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes

  Daniel J. Bridges, Matthew K. Gould, Barbara Nerima, Pascal Mäser, Richard J. S. Burchmore and Harry P. de Koning

  Molecular Pharmacology April 2007, 71 (4) 1098-1108; DOI: https://doi.org/10.1124/mol.106.031351
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  Methylmercury-Induced Increase of Intracellular Ca²⁺ Increases Spontaneous Synaptic Current Frequency in Rat Cerebellar Slices

  Yukun Yuan and William D. Atchison

  Molecular Pharmacology April 2007, 71 (4) 1109-1121; DOI: https://doi.org/10.1124/mol.106.031286
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  Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gα_i Signaling

  Youwen Fang, Elaine Studer, Clint Mitchell, Steven Grant, William M. Pandak, Philip B. Hylemon and Paul Dent

  Molecular Pharmacology April 2007, 71 (4) 1122-1128; DOI: https://doi.org/10.1124/mol.106.032060
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  Protein Kinase C-Dependent Mitochondrial Translocation of Proapoptotic Protein Bax on Activation of Inducible Nitric-Oxide Synthase in Rostral Ventrolateral Medulla Mediates Cardiovascular Depression during Experimental Endotoxemia

  Julie Y. H. Chan, Alice Y. W. Chang, Ling-Lin Wang, Chen-Chun Ou and Samuel H. H. Chan

  Molecular Pharmacology April 2007, 71 (4) 1129-1139; DOI: https://doi.org/10.1124/mol.106.031161
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  Structure-Based Identification of Novel Human γ-Glutamylcysteine Synthetase Inhibitors

  David Hamilton, Jian Hui Wu and Gerald Batist

  Molecular Pharmacology April 2007, 71 (4) 1140-1147; DOI: https://doi.org/10.1124/mol.106.024778
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  In Vivo Regulation of Homer1a Expression in the Striatum by Cocaine

  Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu, Nikhil K. Parelkar, Anish Arora, Lu Yang, Michelle Hains, Eugene E. Fibuch and John Q. Wang

  Molecular Pharmacology April 2007, 71 (4) 1148-1158; DOI: https://doi.org/10.1124/mol.106.028399
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  Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression

  Chuan Chen, Xingguo Cheng, Matthew Z. Dieter, Yuji Tanaka and Curtis D. Klaassen

  Molecular Pharmacology April 2007, 71 (4) 1159-1164; DOI: https://doi.org/10.1124/mol.106.030841
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  Structure of the d(CGCGAATTCGCG)₂ Complex of the Minor Groove Binding Alkylating Agent Alkamin Studied by Mass Spectrometry

  Amin M. S. Abdul Majid, George Smythe, William A. Denny and Laurence P. G. Wakelin

  Molecular Pharmacology April 2007, 71 (4) 1165-1178; DOI: https://doi.org/10.1124/mol.106.030072
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  Interaction of Gα_q and Kir3, G Protein-Coupled Inwardly Rectifying Potassium Channels

  Takeharu Kawano, Peng Zhao, Christina V. Floreani, Yasuko Nakajima, Tohru Kozasa and Shigehiro Nakajima

  Molecular Pharmacology April 2007, 71 (4) 1179-1184; DOI: https://doi.org/10.1124/mol.106.032508