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Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[35S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist

Leigh A. Stoddart, Andrew J. Brown and Graeme Milligan
Molecular Pharmacology April 2007, 71 (4) 994-1005; DOI: https://doi.org/10.1124/mol.106.031534

Article Information

vol. 71 no. 4 994-1005
DOI 
https://doi.org/10.1124/mol.106.031534
PubMed 
17200419
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 5, 2006
  • Accepted January 2, 2007
  • Published online March 21, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Leigh A. Stoddart,
  2. Andrew J. Brown and
  3. Graeme Milligan
  1. Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (L.A.S., G.M.); and Department of Screening and Compound Profiling, GlaxoSmithKline, Harlow, Essex, United Kingdom (A.J.B.)
  1. Address correspondence to:
    Dr. G. Milligan, Davidson Building University of Glasgow, Glasgow G12 8QQ, Scotland, UK. E-mail: g.milligan{at}bio.gla.ac.uk
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Research ArticleArticle

Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[35S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist

Leigh A. Stoddart, Andrew J. Brown and Graeme Milligan
Molecular Pharmacology April 1, 2007, 71 (4) 994-1005; DOI: https://doi.org/10.1124/mol.106.031534
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