Table of Contents

Articles

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  D₂ Receptors Regulate Dopamine Transporter Function via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent and Phosphoinositide 3 Kinase-Independent Mechanism

  Elizabeth A. Bolan, Bronwyn Kivell, Vanaja Jaligam, Murat Oz, Lankupalle D. Jayanthi, Yang Han, Namita Sen, Eneki Urizar, Ivone Gomes, Lakshmi A. Devi, Sammanda Ramamoorthy, Jonathan A. Javitch, Agustin Zapata and Toni S. Shippenberg

  Molecular Pharmacology May 2007, 71 (5) 1222-1232; DOI: https://doi.org/10.1124/mol.106.027763
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  Reversal of Stathmin-Mediated Resistance to Paclitaxel and Vinblastine in Human Breast Carcinoma Cells

  Elizabeth Alli, Jin-Ming Yang, James M. Ford and William N. Hait

  Molecular Pharmacology May 2007, 71 (5) 1233-1240; DOI: https://doi.org/10.1124/mol.106.029702
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  Solute-Inhibitor Interactions in the Plasmodial Surface Anion Channel Reveal Complexities in the Transport Process

  Godfrey Lisk, Seth Scott, Tsione Solomon, Ajay D. Pillai and Sanjay A. Desai

  Molecular Pharmacology May 2007, 71 (5) 1241-1250; DOI: https://doi.org/10.1124/mol.106.030734
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  A Widely Used Retinoic Acid Receptor Antagonist Induces Peroxisome Proliferator-Activated Receptor-γ Activity

  Michael Schupp, Joshua C. Curtin, Roy J. Kim, Andrew N. Billin and Mitchell A. Lazar

  Molecular Pharmacology May 2007, 71 (5) 1251-1257; DOI: https://doi.org/10.1124/mol.106.033662
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  Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-d-aspartate Receptors and Neuronal Nitric-Oxide Synthase

  Wenming Li, Jian Xue, Chunying Niu, Hongjun Fu, Colin S. C. Lam, Jialie Luo, Hugh H. N. Chan, Huaiguo Xue, Kelvin K. W. Kan, Nelson T. K. Lee, Chaoying Li, Yuanping Pang, Mingtao Li, Karl W. K. Tsim, Hualiang Jiang, Kaixian Chen, Xiaoyuan Li and Yifan Han

  Molecular Pharmacology May 2007, 71 (5) 1258-1267; DOI: https://doi.org/10.1124/mol.106.029108
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  Domains Necessary for Gα₁₂ Binding and Stimulation of Protein Phosphatase-2A (PP2A): Is Gα₁₂ a Novel Regulatory Subunit of PP2A?

  Deguang Zhu, Robert I. Tate, Ralf Ruediger, Thomas E. Meigs and Bradley M. Denker

  Molecular Pharmacology May 2007, 71 (5) 1268-1276; DOI: https://doi.org/10.1124/mol.106.033555
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  Insulin Increases the Potency of Glycine at Ionotropic Glycine Receptors

  Valerie B. Caraiscos, Robert P. Bonin, J. Glen Newell, Elzbieta Czerwinska, John F. Macdonald and Beverley A. Orser

  Molecular Pharmacology May 2007, 71 (5) 1277-1287; DOI: https://doi.org/10.1124/mol.106.033563
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  Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development

  Dennis B. McKay, Cheng Chang, Tatiana F. González-Cestari, Susan B. McKay, Raed A. El-Hajj, Darrell L. Bryant, Michael X. Zhu, Peter W. Swaan, Kristjan M. Arason, Aravinda B. Pulipaka, Crina M. Orac and Stephen C. Bergmeier

  Molecular Pharmacology May 2007, 71 (5) 1288-1297; DOI: https://doi.org/10.1124/mol.106.033233
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  Vitamin D₃ Derivatives with Adamantane or Lactone Ring Side Chains are Cell Type-Selective Vitamin D Receptor Modulators

  Yuka Inaba, Keiko Yamamoto, Nobuko Yoshimoto, Manabu Matsunawa, Shigeyuki Uno, Sachiko Yamada and Makoto Makishima

  Molecular Pharmacology May 2007, 71 (5) 1298-1311; DOI: https://doi.org/10.1124/mol.106.032318
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  Agonist-Driven Conformational Changes in the Inner β-Sheet of α7 Nicotinic Receptors

  James T. McLaughlin, Jie Fu and Robert L. Rosenberg

  Molecular Pharmacology May 2007, 71 (5) 1312-1318; DOI: https://doi.org/10.1124/mol.106.033092
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  Maternal Cocaine Administration Causes an Epigenetic Modification of Protein Kinase Cϵ Gene Expression in Fetal Rat Heart

  Haitao Zhang, Agus Darwanto, Thomas A. Linkhart, Lawrence C. Sowers and Lubo Zhang

  Molecular Pharmacology May 2007, 71 (5) 1319-1328; DOI: https://doi.org/10.1124/mol.106.032011
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  Real-Time Analysis of Agonist-Induced Activation of Protease-Activated Receptor 1/Gα_i1 Protein Complex Measured by Bioluminescence Resonance Energy Transfer in Living Cells

  Mohammed A. Ayoub, Damien Maurel, Virginie Binet, Michel Fink, Laurent Prézeau, Hervé Ansanay and Jean-Philippe Pin

  Molecular Pharmacology May 2007, 71 (5) 1329-1340; DOI: https://doi.org/10.1124/mol.106.030304
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  Conformationally Sensitive Reactivity to Permeant Sulfhydryl Reagents of Cysteine Residues Engineered into Helical Hairpin 1 of the Glutamate Transporter GLT-1

  Irina Shlaifer and Baruch I. Kanner

  Molecular Pharmacology May 2007, 71 (5) 1341-1348; DOI: https://doi.org/10.1124/mol.106.032607
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  Protean Agonism at the Dopamine D₂ Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of G_o1 but an Antagonist/Inverse Agonist for G_i1,G_i2, and G_i3

  J. Robert Lane, Ben Powney, Alan Wise, Steven Rees and Graeme Milligan

  Molecular Pharmacology May 2007, 71 (5) 1349-1359; DOI: https://doi.org/10.1124/mol.106.032722
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  Identification of a Second Blocker Binding Site at the Cytoplasmic Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

  Chantal N. St. Aubin, Jing-Jun Zhou and Paul Linsdell

  Molecular Pharmacology May 2007, 71 (5) 1360-1368; DOI: https://doi.org/10.1124/mol.106.031732
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  Molecular Signalling Mediating the Protective Effect of A₁ Adenosine and mGlu3 Metabotropic Glutamate Receptor Activation against Apoptosis by Oxygen/Glucose Deprivation in Cultured Astrocytes

  Renata Ciccarelli, Iolanda D'Alimonte, Patrizia Ballerini, Mariagrazia D'Auro, Eleonora Nargi, Silvana Buccella, Patrizia Di Iorio, Valeria Bruno, Ferdinando Nicoletti and Francesco Caciagli

  Molecular Pharmacology May 2007, 71 (5) 1369-1380; DOI: https://doi.org/10.1124/mol.106.031617
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  A Critical Role of Luteolin-Induced Reactive Oxygen Species in Blockage of Tumor Necrosis Factor-Activated Nuclear Factor-κB Pathway and Sensitization of Apoptosis in Lung Cancer Cells

  Wei Ju, Xia Wang, Honglian Shi, Wenshu Chen, Steven A. Belinsky and Yong Lin

  Molecular Pharmacology May 2007, 71 (5) 1381-1388; DOI: https://doi.org/10.1124/mol.106.032185
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  Interaction of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 with the Negative Allosteric Antagonist Site Is Required for Potentiation of Receptor Responses

  Yelin Chen, Yi Nong, Cyril Goudet, Kamondanai Hemstapat, Tomas de Paulis, Jean-Philippe Pin and P. Jeffrey Conn

  Molecular Pharmacology May 2007, 71 (5) 1389-1398; DOI: https://doi.org/10.1124/mol.106.032425
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  PAR1, but Not PAR4, Activates Human Platelets through a G_i/o/Phosphoinositide-3 Kinase Signaling Axis

  Bryan Voss, Joseph N. McLaughlin, Michael Holinstat, Roy Zent and Heidi E. Hamm

  Molecular Pharmacology May 2007, 71 (5) 1399-1406; DOI: https://doi.org/10.1124/mol.106.033365
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  Activation of Single Nicotinic Receptor Channels from Caenorhabditis elegans Muscle

  Diego Rayes, Marina Flamini, Guillermina Hernando and Cecilia Bouzat

  Molecular Pharmacology May 2007, 71 (5) 1407-1415; DOI: https://doi.org/10.1124/mol.106.033514
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  Quantitative Evaluation of Human δ Opioid Receptor Desensitization Using the Operational Model of Drug Action

  Edita Navratilova, Sue Waite, Dagmar Stropova, Miriam C. Eaton, Isabel D. Alves, Victor J. Hruby, William R. Roeske, Henry I. Yamamura and Eva V. Varga

  Molecular Pharmacology May 2007, 71 (5) 1416-1426; DOI: https://doi.org/10.1124/mol.106.030023
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  Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase

  Riku Korhonen, Katrin Linker, Andrea Pautz, Ulrich Förstermann, Eeva Moilanen and Hartmut Kleinert

  Molecular Pharmacology May 2007, 71 (5) 1427-1434; DOI: https://doi.org/10.1124/mol.106.033449
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  Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1

  Vivian Wai Yan Lui, Amanda L. Boehm, Priya Koppikar, Rebecca J. Leeman, Daniel Johnson, Michelene Ogagan, Erin Childs, Maria Freilino and Jennifer Rubin Grandis

  Molecular Pharmacology May 2007, 71 (5) 1435-1443; DOI: https://doi.org/10.1124/mol.106.032284
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  Correction to “A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure”

  Molecular Pharmacology May 2007, 71 (5) 1444; DOI: https://doi.org/10.1124/mol.71.5.1444