Abstract
Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. (p. 1319) show that a specific methylation occurs at the protein kinase Cϵ (PKCϵ) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKCϵ, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.
Footnotes
-
Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org.
-
doi:10.1124/mol.107.035196.
-
Please see the related article on page 1319.
-
ABBREVIATIONS: PKC, protein kinase C; AP-1, activator protein-1.
- Received February 13, 2007.
- Accepted February 15, 2007.
- The American Society for Pharmacology and Experimental Therapeutics
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
The Thrill Can Kill: Murder by Methylation
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement