Abstract
Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. (p. 1319) show that a specific methylation occurs at the protein kinase Cϵ (PKCϵ) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKCϵ, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.
Footnotes
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Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org.
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doi:10.1124/mol.107.035196.
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Please see the related article on page 1319.
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ABBREVIATIONS: PKC, protein kinase C; AP-1, activator protein-1.
- Received February 13, 2007.
- Accepted February 15, 2007.
- The American Society for Pharmacology and Experimental Therapeutics
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