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Protean Agonism at the Dopamine D2 Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of Go1 but an Antagonist/Inverse Agonist for Gi1,Gi2, and Gi3

J. Robert Lane, Ben Powney, Alan Wise, Steven Rees and Graeme Milligan
Molecular Pharmacology May 2007, 71 (5) 1349-1359; DOI: https://doi.org/10.1124/mol.106.032722

Article Information

vol. 71 no. 5 1349-1359
DOI 
https://doi.org/10.1124/mol.106.032722
PubMed 
17287401
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received November 15, 2006
  • Accepted February 7, 2007
  • Published online April 25, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. Robert Lane,
  2. Ben Powney,
  3. Alan Wise,
  4. Steven Rees and
  5. Graeme Milligan
  1. Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (J.R.L., G.M.); and Screening & Compound Profiling, GlaxoSmithKline Research & Development, Harlow, Essex, United Kingdom (A.W., S.R., B.P.)
  1. Address correspondence to:
    Dr. G. Milligan, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. E-mail: g.milligan{at}bio.gla.ac.uk
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Research ArticleArticle

Protean Agonism at the Dopamine D2 Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of Go1 but an Antagonist/Inverse Agonist for Gi1,Gi2, and Gi3

J. Robert Lane, Ben Powney, Alan Wise, Steven Rees and Graeme Milligan
Molecular Pharmacology May 1, 2007, 71 (5) 1349-1359; DOI: https://doi.org/10.1124/mol.106.032722
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