%PDF-1.4
%
1 0 obj
<>
endobj
166 0 obj
<>stream
Creo Normalizer JTP
2024-03-18T23:20:33-07:00
2007-05-14T10:54:50-04:00
2024-03-18T23:20:33-07:00
uuid:f8fcba46-835d-459f-b01d-7c844f52576a
uuid:6c614282-1dd2-11b2-0a00-3800b88fceff
application/pdf
endstream
endobj
2 0 obj
<>
endobj
6 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[9.0 9.0 594.0 792.0]/Type/Page>>
endobj
67 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[9.0 9.0 594.0 792.0]/Type/Page>>
endobj
118 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/TrimBox[9.0 9.0 594.0 792.0]/Type/Page>>
endobj
178 0 obj
[183 0 R]
endobj
157 0 obj
<>
endobj
179 0 obj
<>stream
BT
/CS0 cs 1 scn
/GS0 gs
/T1_0 1 Tf
8 0 0 8 31.1648 738.8835 Tm
(\001)Tj
/T1_1 1 Tf
6 0 0 6 33.3266 738.8835 Tm
(S)Tj
10 0 0 10 44.1662 738.8835 Tm
[(Subunit-Stoichiometric)-332.9 (Evidence)-332.9 (for)-332.9 (Kir6.2)-332.9 (Channel)-332.9 (Gating,)-332.9 (ATP)-332.9 (Binding,)-333 (and)-332.9 (Binding-Gating)]TJ
1.9999 -1.2 Td
(Coupling)Tj
/T1_2 1 Tf
0 -1.2 TD
[(Runping)-332.9 (Wang,)-332.9 (Xiaoli)-332.9 (Zhang,)-332.9 (Ningren)-332.9 (Cui,)-332.9 (Jianping)-332.9 (Wu,)-333 (Hailan)-332.9 (Piao,)-333 (Xueren)-332.9 (Wang,)-333 (Junda)-332.9 (Su,)]TJ
T*
[(and)-332.9 (Chun)-332.9 (Jiang)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1646)Tj
-49.3773 -2.2 Td
[(Inhibition)-332.9 (of)-332.9 (Vascular)-332.9 (Endothelial)-332.9 (Growth)-332.9 (Factor)-332.9 (Cotranslational)-333 (Translocation)-332.9 (by)-332.9 (the)-332.9 (Cyclopeptolide)]TJ
2 -1.2 Td
(CAM741)Tj
/T1_2 1 Tf
T*
[(Hanna)-332.9 (Harant,)-332.9 (Barbara)-332.9 (Wolff,)-333 (Erwin)-332.9 (P.)-332.9 (Schreiner,)-332.9 (Berndt)-333 (Oberhauser,)-332.9 (Lotte)-332.9 (Hofer,)-333 (Nicole)-333 (Lettner,)]TJ
T*
[(Sabine)-332.9 (Maier,)-332.9 (Jan)-332.9 (E.)-332.9 (de)-332.9 (Vries,)-333 (and)-332.9 (Ivan)-332.9 (J.)-333 (Lindley)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1657)Tj
-49.3773 -2.2 Td
(G)Tj
/T1_3 1 Tf
10 0 1.554 10 51.9446 622.8835 Tm
(\001)Tj
/T1_1 1 Tf
7.5 0 0 6.5 58.0546 620.6335 Tm
(q)Tj
10 0 0 10 62.2245 622.8835 Tm
[(-Mediated)-332.9 (Regulation)-332.9 (of)-333 (TASK3)-332.9 (Two-Pore)-332.9 (Domain)-332.9 (Potassium)-332.9 (Channels:)-333 (The)-333 (Role)-332.9 (of)-333 (Protein)]TJ
0.194 -1.2 Td
[(Kinase)-332.9 (C)]TJ
/T1_2 1 Tf
T*
[(Emma)-332.9 (L.)-332.9 (Veale,)-332.9 (Louise)-332.9 (E.)-333 (Kennard,)-333 (Gemma)-332.9 (L.)-333 (Sutton,)-333 (Georgina)-332.9 (MacKenzie,)-332.9 (Cristina)-332.9 (Sandu,)-333 (and)]TJ
T*
[(Alistair)-332.9 (Mathie)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1666)Tj
/T1_0 1 Tf
8 0 0 8 31.1648 564.8835 Tm
(\001)Tj
/T1_1 1 Tf
6 0 0 6 33.3266 564.8835 Tm
(S)Tj
10 0 0 10 44.1662 564.8835 Tm
[(Quercetin)-332.9 (Activates)-332.9 (an)-332.9 (Angiogenic)-332.9 (Pathway,)-333 (Hypoxia)-332.9 (Inducible)-332.9 (Factor)-333 (\(HIF\)-1-Vascular)-333 (Endothelial)]TJ
1.9999 -1.2 Td
[(Growth)-332.9 (Factor,)-332.9 (by)-332.9 (Inhibiting)-332.9 (HIF-Prolyl)-332.9 (Hydroxylase:)-333 (a)-332.9 (Structural)-333 (Analysis)-332.9 (of)-333 (Quercetin)-332.9 (for)]TJ
T*
[(Inhibiting)-332.9 (HIF-Prolyl)-332.9 (Hydroxylase)]TJ
/T1_2 1 Tf
T*
[(Hyunchu)-332.9 (Jeon,)-332.9 (Heejung)-332.9 (Kim,)-333 (Daekyu)-332.9 (Choi,)-333 (Duksoo)-332.9 (Kim,)-333 (Shi-Young)-332.9 (Park,)-333 (Yung-Jin)-332.9 (Kim,)]TJ
T*
[(Young)-332.9 (Mi)-332.9 (Kim,)-333 (and)-332.9 (Yunjin)-332.9 (Jung)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1676)Tj
-49.3773 -2.2 Td
[(The)-332.9 (Amine-Containing)-332.9 (Cutaneous)-333 (Irritant)-332.9 (Heptylamine)-332.9 (Inhibits)-332.9 (the)-332.9 (Volume-Regulated)-332.9 (Anion)-332.9 (Channel)]TJ
2 -1.2 Td
[(and)-332.9 (Mobilizes)-332.9 (Intracellular)-332.9 (Calcium)-332.9 (in)-332.9 (Normal)-332.9 (Human)-332.9 (Epidermal)-333 (Keratinocytes)]TJ
/T1_2 1 Tf
T*
[(Matthieu)-332.9 (Raoux,)-332.9 (Ce)388.4 (\264)-55.4 (cile)-333 (Colomban,)-333 (Patrick)-332.9 (Delmas,)-333 (and)-332.9 (Marcel)-332.9 (Crest)]TJ
/T1_1 1 Tf
47.3772 0 Td
(1685)Tj
-49.3773 -2.2 Td
[(The)-332.9 (Thiazolidinedione)-332.9 (Pioglitazone)-332.9 (Alters)-332.9 (Mitochondrial)-333 (Function)-332.9 (in)-332.9 (Human)-332.9 (Neuron-Like)-332.9 (Cells)]TJ
/T1_2 1 Tf
2 -1.2 Td
[(Sangeeta)-332.9 (Ghosh,)-332.9 (Nishant)-333 (Patel,)-332.9 (Douglas)-332.9 (Rahn,)-333 (Jenna)-332.9 (McAllister,)-333 (Sina)-332.9 (Sadeghi,)-332.9 (Geoffrey)-332.9 (Horwitz,)]TJ
T*
[(Diana)-332.9 (Berry,)-333 (Kai)-332.9 (Xuan)-332.9 (Wang,)-333 (and)-332.9 (Russell)-332.9 (H.)-333 (Swerdlow)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1695)Tj
-49.3773 -2.2 Td
[(Fisetin,)-332.9 (an)-332.9 (Inhibitor)-332.9 (of)-332.9 (Cyclin-Dependent)-333 (Kinase)-332.9 (6,)-332.9 (Down-Regulates)-332.9 (Nuclear)-332.9 (Factor-)]TJ
/T1_3 1 Tf
10 0 1.554 10 440.8051 402.8835 Tm
(\004)Tj
/T1_1 1 Tf
10 0 0 10 446.365 402.8835 Tm
[(B-Regulated)-332.9 (Cell)]TJ
-38.22 -1.2 Td
[(Proliferation,)-332.9 (Antiapoptotic)-332.9 (and)-332.9 (Metastatic)-332.9 (Gene)-332.9 (Products)-332.9 (through)-332.9 (the)-332.9 (Suppression)-332.9 (of)-333 (TAK-1)-332.9 (and)]TJ
T*
[(Receptor-Interacting)-332.9 (Protein-Regulated)-332.9 (I)]TJ
/T1_3 1 Tf
10 0 1.554 10 255.611 378.8835 Tm
(\004)Tj
/T1_1 1 Tf
10 0 0 10 261.171 378.8835 Tm
(B)Tj
/T1_3 1 Tf
10 0 1.554 10 268.3908 378.8835 Tm
(\001)Tj
/T1_1 1 Tf
10 0 0 10 277.8303 378.8835 Tm
[(Kinase)-332.9 (Activation)]TJ
/T1_2 1 Tf
-21.3666 -1.2 Td
[(Bokyung)-332.9 (Sung,)-333 (Manoj)-332.9 (K.)-333 (Pandey,)-333 (and)-332.9 (Bharat)-332.9 (B.)-333 (Aggarwal)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1703)Tj
-49.3773 -2.2 Td
[(Pioglitazone)-332.9 (and)-332.9 (Rosiglitazone)-332.9 (Decrease)-332.9 (Prostaglandin)-332.9 (E)]TJ
7.5 0 0 6.5 311.5687 342.6335 Tm
(2)Tj
10 0 0 10 319.0682 344.8835 Tm
[(in)-332.9 (Non\226Small-Cell)-333 (Lung)-332.9 (Cancer)-332.9 (Cells)-332.9 (by)]TJ
-25.4903 -1.2 Td
[(Up-Regulating)-332.9 (15-Hydroxyprostaglandin)-332.9 (Dehydrogenase)]TJ
/T1_2 1 Tf
T*
[(Saswati)-333 (Hazra,)-333 (Raj)-333 (K.)-333 (Batra,)-332.9 (Hsin)-332.9 (H.)-333 (Tai,)-333 (Sherven)-332.9 (Sharma,)-333 (Xiaoyan)-332.9 (Cui,)-333 (and)-332.9 (Steven)-332.9 (M.)-333 (Dubinett)]TJ
/T1_1 1 Tf
47.3773 0 Td
(1715)Tj
/T1_0 1 Tf
9 0 0 9 44.1648 94.3835 Tm
(\001)Tj
/T1_1 1 Tf
7 0 0 7 46.5967 94.3835 Tm
(S)Tj
10 0 0 10 56.0068 94.3835 Tm
[(Supplemental)-332.9 (material)-332.9 (is)-332.9 (available)-332.9 (online)-332.9 (at)-332.9 (http://molpharm.aspetjournals.org.)]TJ
/T1_2 1 Tf
8 0 0 8 59.1648 59.3835 Tm
[(About)-320 (the)-320 (cover:)]TJ
/T1_1 1 Tf
7.8988 0 Td
[(Results)-320 (obtained)-320 (from)-319.9 (CM)-319.9 (studies)-320 (of)-320 (WT)-320 (CB)]TJ
6 0 0 5 288.5586 57.6335 Tm
(1)Tj
8 0 0 8 294.4542 59.3835 Tm
[(TMH7)-320 (\(green\))-320 (and)-319.9 (the)-320 (CB)]TJ
6 0 0 5 392.2355 57.6335 Tm
(1)Tj
8 0 0 8 398.1311 59.3835 Tm
[(S7.39\(383\)A)-319.9 (mutant)-320 (TMH7)-319.9 (\(magenta\).)]TJ
-42.3708 -1.25 Td
[(Please)-332.7 (see)-332.7 (the)-332.7 (article)-332.7 (by)-332.7 (Kapur)-332.7 (et)-332.7 (al.)-332.7 (on)-332.7 (page)-332.7 (1512)-332.7 (of)-332.7 (this)-332.7 (issue.)]TJ
ET
/CS0 CS 1 SCN
48.5 w
/GS1 gs
44.165 58.133 m
47.165 58.133 l
S
3 w
47.165 80.884 m
558.165 80.884 l
S
48.5 w
555.165 58.133 m
558.165 58.133 l
S
3 w
44.165 35.383 m
555.165 35.383 l
S
BT
0 g
/GS2 gs
/T1_4 1 Tf
0 -9 9 0 586 386.75706 Tm
( at ASPET Journals on March 18, 2024)Tj
/GS2 gs
-11.22099 0 Td
(molpharm.aspetjournals.org)Tj
/GS2 gs
-7.55399 0 Td
(Downloaded from )Tj
ET
endstream
endobj
142 0 obj
<>
endobj
121 0 obj
<>
endobj
126 0 obj
<>
endobj
129 0 obj
<>
endobj
132 0 obj
<>
endobj
172 0 obj
<>
endobj
133 0 obj
<>
endobj
134 0 obj
<>
endobj
135 0 obj
<>stream
CCGJGM+MathematicalPi-One mf|PTZE YkH9251H9252H9253H9260Copyright (c) 1990 Adobe Systems Incorporated. All Rights Reserved.MathematicalPi-One abgk wcs9kM`oWma5": ƼxWextqVػߥ{m=MNXZadeLLfxwb5cYs8)ԩ,:=3FѦA>UPKtxxtx}st^34dO,1Dty}~{<yda8UpsͷFvnrT}=s*lB4_V9CaSCyP?DAo~h|z/bɥwdboigu[>
endobj
131 0 obj
<>stream
HTkTS@#Kc5E|H+fE% ! oADPai4Z+EZ[Gi;n՟ܾMK$74Ll,=~ɝ))rL2)î׃xC]]u̓[=Js)E*"Q$tjX/ArфpAo3\KPeyl;xX}2FwƱsݪ?Y%;$[4L/ۥ>;uPvH$G Č@!G)@!_%p4\vn4D$2Z' +-&k1$
&lӓnFС3^C̔--c@*"(;QB%6Q(hOSk]MkE=_wB
_5wb.D=F)KhM.c[8#Z{Qk7zMr܍k)MFzFƭFcFe.YOq
"*Q{62jk6(9([?HTg3.D˱]O(M {͝w4ܤafOfbl3DX=Z"txRUL^M舙J1|s&STy^yN,E_ LBGY}M)Q<^@_ſI$f5X>>-UmG7ߞ!qsA<wAlHeA(W,2cBGmQ{!9۲ֲEmgRt͌ *LDb剆jkXu4$ྲ҃q!kq?B0kU5R~1!K+=.aq<Y]T`:I+b8Xhˤ"yY=؆wX|\.id7ydCgm
l7pLr_ȓM)*
nZ3X> e;ϴ%%l߾lgcQ'ZVt`5!F>O#Ik붼,&vbUfӷjYWʍo]bk3h&cM9kPaa &y;s3(c*'ķ;rIpD89$7Y,3,]4Z
)Kyxl|"v9R6w3ӽ-baxaypY3e:bf7O^CqͱmY= **seTy9#畕^?@;m0&t/t=,5!ށv>|BlUd]_)L>ti.d#{OH/x aOV
lTDW7W6rk2t_Ս8Uuܢh^
5,pGo1v7S(ry=A*ӺjGFgF[>Vo+J}b
;s܍/A
ۙPwCS)inij~I^P9Pw}^ۇx=s
~MpP( +ëx=1 o*"VeiRTDC\MA' (Di@ZV
k+KM̈́iVa(g8ur8sf^7&9g&c֫~~_-@mM xg$ncM
Vh`|'tM,|.-h Ȗ$[}yd rX| qQKuwRh/lN:J,:$A=0ΦuJNn:]ġd:~#RF`t@Os[yOOaσA5i TWP\>Ŋa[!5,n|8LO5N$:}jV0La3t"4SVD
QIIf4GzPg2Ч06*LKLO11XS3&@-N2A_Mhj汋W־=w^bl
AuҥR"ztq4κOIvŸa5^A"mU?אuQ(68
^DFQ(ˮ,N]ӢoK D%:$B6l,h 4k{q%I2IrOCMeŅLĩ,wԚ_/#o
C.U8'2S*NIR-%yY?7;J9>~17ƒXqsTP/\>0ٲ"ɰrJSU?x&&2+;+돒ym,G 86kΠa[:M#