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Research ArticleArticle

Antidiabetes and Antiobesity Effect of Cryptotanshinone via Activation of AMP-Activated Protein Kinase

Eun Ju Kim, Seung-Nam Jung, Kun Ho Son, Sung Ran Kim, Tae Youl Ha, Myoung Gyu Park, In Gun Jo, Jong Guk Park, Wonchae Choe, Sung-Soo Kim and Joohun Ha
Molecular Pharmacology July 2007, 72 (1) 62-72; DOI: https://doi.org/10.1124/mol.107.034447
Eun Ju Kim
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Seung-Nam Jung
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Kun Ho Son
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Sung Ran Kim
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Tae Youl Ha
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Myoung Gyu Park
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In Gun Jo
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Jong Guk Park
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Wonchae Choe
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Sung-Soo Kim
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Joohun Ha
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Abstract

Metabolic disorders, including type 2 diabetes and obesity, represent major health risks in industrialized countries. AMP-activated protein kinase (AMPK) has become the focus of a great deal of attention as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK has been demonstrated to mediate, at least in part, the effects of a number of physiological and pharmacological factors that exert beneficial effects on these disorders. Thus, the identification of a compound that activates the AMPK pathway would contribute significantly to the treatment and management of such syndromes. In service of this goal, we have screened a variety of naturally occurring compounds and have identified one compound, cryptotanshinone, as a novel AMPK pathway activator. Cryptotanshinone was originally isolated from the dried roots of Salvia militorrhiza, an herb that is used extensively in Asian medicine and that is known to exert beneficial effects on the circulatory system. For the first time, in the present study, we have described the potent antidiabetic and antiobesity effects of cryptotanshinone, both in vitro and in vivo. Our findings suggest that the activation of the AMPK pathway might contribute to the development of novel therapeutic approaches for the treatment of metabolic disorders such as type 2 diabetes and obesity.

Footnotes

  • This work was supported by grant R13-2002-020-01004-0 from the Korea Science and Engineering Foundation and by a grant from Seoul R&BD program.

  • ABBREVIATIONS: AMPK, AMP-activated protein kinase; AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; ACC, acetyl-CoA carboxylase; DMEM, Dulbecco's modified Eagle's medium; PI-3, phosphatidylinositol-3; PBS, phosphate-buffered saline; KRB, Krebs-Ringer phosphate buffer; Glut4, glucose transporter 4; CPT-I, carnitine palmitoyl transferase I; PGC-1α, peroxisome proliferator-activated receptor-γ coactivator-1α; UCP, uncoupling protein; DIO, diet-induced obese; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; mTOR, mammalian target of rapamycin; IGF-IRβ, insulin-like growth factor 1 receptor β.

    • Received January 23, 2007.
    • Accepted April 11, 2007.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 72 (1)
Molecular Pharmacology
Vol. 72, Issue 1
1 Jul 2007
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Research ArticleArticle

Antidiabetes and Antiobesity Effect of Cryptotanshinone via Activation of AMP-Activated Protein Kinase

Eun Ju Kim, Seung-Nam Jung, Kun Ho Son, Sung Ran Kim, Tae Youl Ha, Myoung Gyu Park, In Gun Jo, Jong Guk Park, Wonchae Choe, Sung-Soo Kim and Joohun Ha
Molecular Pharmacology July 1, 2007, 72 (1) 62-72; DOI: https://doi.org/10.1124/mol.107.034447

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Research ArticleArticle

Antidiabetes and Antiobesity Effect of Cryptotanshinone via Activation of AMP-Activated Protein Kinase

Eun Ju Kim, Seung-Nam Jung, Kun Ho Son, Sung Ran Kim, Tae Youl Ha, Myoung Gyu Park, In Gun Jo, Jong Guk Park, Wonchae Choe, Sung-Soo Kim and Joohun Ha
Molecular Pharmacology July 1, 2007, 72 (1) 62-72; DOI: https://doi.org/10.1124/mol.107.034447
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