Table of Contents

Articles

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  Trapping of a Nonpeptide Ligand by the Extracellular Domains of the Gonadotropin-Releasing Hormone Receptor Results in Insurmountable Antagonism

  Trudy A. Kohout, Qiu Xie, Shelby Reijmers, Kenneth J. Finn, Zhiqiang Guo, Yun-Fei Zhu and R. Scott Struthers

  Molecular Pharmacology August 2007, 72 (2) 238-247; DOI: https://doi.org/10.1124/mol.107.035535
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  RETRACTION: Erlotinib, an Effective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces p27^KIP1 Up-Regulation and Nuclear Translocation in Association with Cell Growth Inhibition and G₁/S Phase Arrest in Human Non-Small-Cell Lung Cancer Cell Lines

  Yi-He Ling, Tianhong Li, Ziqiang Yuan, Missak Haigentz, Thomas K. Weber and Roman Perez-Soler

  Molecular Pharmacology August 2007, 72 (2) 248-258; DOI: https://doi.org/10.1124/mol.107.034827
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  APETx1 from Sea Anemone Anthopleura elegantissima Is a Gating Modifier Peptide Toxin of the Human Ether-a-go-go- Related Potassium Channel

  M. Zhang, X.-S. Liu, S. Diochot, M. Lazdunski and G.-N. Tseng

  Molecular Pharmacology August 2007, 72 (2) 259-268; DOI: https://doi.org/10.1124/mol.107.035840
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  UR-1505, a New Salicylate, Blocks T Cell Activation through Nuclear Factor of Activated T Cells

  Juan Román, Alberto Fernández de Arriba, Sonia Barrón, Pedro Michelena, Marta Giral, Manuel Merlos, Elvira Bailón, Mònica Comalada, Julio Gálvez, Antonio Zarzuelo and Isabel Ramis

  Molecular Pharmacology August 2007, 72 (2) 269-279; DOI: https://doi.org/10.1124/mol.107.035212
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  Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

  Maoqing Dong, Polo C.-H. Lam, Fan Gao, Keiko Hosohata, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan and Laurence J. Miller

  Molecular Pharmacology August 2007, 72 (2) 280-290; DOI: https://doi.org/10.1124/mol.107.035402
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  A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M₂ Muscarinic Receptor

  Tod Steinfeld, Mathai Mammen, Jacqueline A. M. Smith, Richard D. Wilson and Jeffrey R. Jasper

  Molecular Pharmacology August 2007, 72 (2) 291-302; DOI: https://doi.org/10.1124/mol.106.033746
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  Bradykinin-Induced Nuclear Factor of Activated T-Cells-Dependent Transcription in Rat Dorsal Root Ganglion Neurons

  Joshua G. Jackson, Yuriy M. Usachev and Stanley A. Thayer

  Molecular Pharmacology August 2007, 72 (2) 303-310; DOI: https://doi.org/10.1124/mol.107.035048
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  Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs

  Amélie Lansiaux, Stéphane Léonce, Laurence Kraus-Berthier, Christine Bal-Mahieu, Romain Mazinghien, Sébastien Didier, Marie-Hélène David-Cordonnier, Patrick Hautefaye, Gilbert Lavielle, Christian Bailly, John A. Hickman and Alain Pierré

  Molecular Pharmacology August 2007, 72 (2) 311-319; DOI: https://doi.org/10.1124/mol.107.034637
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  Characterization of an NBS1 C-Terminal Peptide That Can Inhibit Ataxia Telangiectasia Mutated (ATM)-Mediated DNA Damage Responses and Enhance Radiosensitivity

  Mickael J. Cariveau, Xi Tang, Xiao-Li Cui and Bo Xu

  Molecular Pharmacology August 2007, 72 (2) 320-326; DOI: https://doi.org/10.1124/mol.107.036681
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  Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8

  Pia C. Jensen, Rie Nygaard, Stefanie Thiele, Amy Elder, Guoming Zhu, Roland Kolbeck, Shomir Ghosh, Thue W. Schwartz and Mette M. Rosenkilde

  Molecular Pharmacology August 2007, 72 (2) 327-340; DOI: https://doi.org/10.1124/mol.107.035543
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  Critical Role for Sphingosine Kinase-1 in Regulating Survival of Neuroblastoma Cells Exposed to Amyloid-β Peptide

  Anne Gomez-Brouchet, Dimitri Pchejetski, Leyre Brizuela, Virginie Garcia, Marie-Françoise Altié, Marie-Lise Maddelein, Marie-Bernadette Delisle and Olivier Cuvillier

  Molecular Pharmacology August 2007, 72 (2) 341-349; DOI: https://doi.org/10.1124/mol.106.033738
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  Transcriptional Regulation of Brain-Derived Neurotrophic Factor in the Amygdala during Consolidation of Fear Memory

  Li-Chin Ou and Po-Wu Gean

  Molecular Pharmacology August 2007, 72 (2) 350-358; DOI: https://doi.org/10.1124/mol.107.034934
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  β₁ (KCNMB1) Subunits Mediate Lithocholate Activation of Large-Conductance Ca²⁺-Activated K⁺ Channels and Dilation in Small, Resistance-Size Arteries

  Anna N. Bukiya, Jianxi Liu, Ligia Toro and Alejandro M. Dopico

  Molecular Pharmacology August 2007, 72 (2) 359-369; DOI: https://doi.org/10.1124/mol.107.034330
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  5-Androstenediol Promotes Survival of γ-Irradiated Human Hematopoietic Progenitors through Induction of Nuclear Factor-κB Activation and Granulocyte Colony-Stimulating Factor Expression

  Mang Xiao, Cynthia E. Inal, Vaishali I. Parekh, Cheng-Min Chang and Mark H. Whitnall

  Molecular Pharmacology August 2007, 72 (2) 370-379; DOI: https://doi.org/10.1124/mol.107.035394
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  Identification of the Atypical L-Type Ca²⁺ Channel Blocker Diltiazem and Its Metabolites As Ghrelin Receptor Agonists

  Jian-Nong Ma, Hans H. Schiffer, Anne E. Knapp, Jean Wang, Kenneth K. Wong, Erika A. Currier, Michelle Owens, Norman R. Nash, Luis R. Gardell, Mark R. Brann, Roger Olsson and Ethan S. Burstein

  Molecular Pharmacology August 2007, 72 (2) 380-386; DOI: https://doi.org/10.1124/mol.107.034298
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  Multidrug Resistance Proteins 2 and 3 Provide Alternative Routes for Hepatic Excretion of Morphine-Glucuronides

  Koen van de Wetering, Noam Zelcer, Annemieke Kuil, Wouter Feddema, Michel Hillebrand, Maria L. H. Vlaming, Alfred H. Schinkel, Jos H. Beijnen and Piet Borst

  Molecular Pharmacology August 2007, 72 (2) 387-394; DOI: https://doi.org/10.1124/mol.107.035592
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  Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

  Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Carolina Simioni, Edward Leung, Stephen Maclennan, Pier Giovanni Baraldi and Pier Andrea Borea

  Molecular Pharmacology August 2007, 72 (2) 395-406; DOI: https://doi.org/10.1124/mol.106.032920
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  Glitazones Induce Astroglioma Cell Death by Releasing Reactive Oxygen Species from Mitochondria: Modulation of Cytotoxicity by Nitric Oxide

  José M. Pérez-Ortiz, Pedro Tranque, Miguel Burgos, Cecilia F. Vaquero and Juan Llopis

  Molecular Pharmacology August 2007, 72 (2) 407-417; DOI: https://doi.org/10.1124/mol.106.032458
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  Suppression of Osteoclastogenesis by N,N-Dimethyl-D-erythro-sphingosine: A Sphingosine Kinase Inhibition-Independent Action

  Hyung Joon Kim, Youngkyun Lee, Eun-Ju Chang, Hyun-Man Kim, Sam-Pyo Hong, Zang Hee Lee, Jiyoon Ryu and Hong-Hee Kim

  Molecular Pharmacology August 2007, 72 (2) 418-428; DOI: https://doi.org/10.1124/mol.107.034173
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  N-Ethylmaleimide-Sensitive Factor Regulates β₂ Adrenoceptor Trafficking and Signaling in Cardiomyocytes

  Yongyu Wang, Benjamin Lauffer, Mark Von Zastrow, Brian K. Kobilka and Yang Xiang

  Molecular Pharmacology August 2007, 72 (2) 429-439; DOI: https://doi.org/10.1124/mol.107.037747
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  Inhibition of Hypoxia-Induced Increase of Blood-Brain Barrier Permeability by YC-1 through the Antagonism of HIF-1α Accumulation and VEGF Expression

  Wei-Lan Yeh, Dah-Yuu Lu, Chun-Jung Lin, Houng-Chi Liou and Wen-Mei Fu

  Molecular Pharmacology August 2007, 72 (2) 440-449; DOI: https://doi.org/10.1124/mol.107.036418
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  Desensitization of the Dopamine D1 and D2 Receptor Hetero-Oligomer Mediated Calcium Signal by Agonist Occupancy of Either Receptor

  Christopher H. So, Vaneeta Verma, Brian F. O'Dowd and Susan R. George

  Molecular Pharmacology August 2007, 72 (2) 450-462; DOI: https://doi.org/10.1124/mol.107.034884
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  Structure-Function Studies of Allosteric Agonism at M₂ Muscarinic Acetylcholine Receptors

  Lauren T. May, Vimesh A. Avlani, Christopher J. Langmead, Hugh J. Herdon, Martyn D. Wood, Patrick M. Sexton and Arthur Christopoulos

  Molecular Pharmacology August 2007, 72 (2) 463-476; DOI: https://doi.org/10.1124/mol.107.037630
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  A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

  Michael A. Benneyworth, Zixiu Xiang, Randy L. Smith, Efrain E. Garcia, P. Jeffrey Conn and Elaine Sanders-Bush

  Molecular Pharmacology August 2007, 72 (2) 477-484; DOI: https://doi.org/10.1124/mol.107.035170