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Research ArticleArticle

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

Maoqing Dong, Polo C.-H. Lam, Fan Gao, Keiko Hosohata, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan and Laurence J. Miller
Molecular Pharmacology August 2007, 72 (2) 280-290; DOI: https://doi.org/10.1124/mol.107.035402
Maoqing Dong
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Polo C.-H. Lam
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Fan Gao
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Keiko Hosohata
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Delia I. Pinon
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Patrick M. Sexton
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Ruben Abagyan
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Laurence J. Miller
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
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Article Information

vol. 72 no. 2 280-290
DOI 
https://doi.org/10.1124/mol.107.035402
PubMed 
17475809

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 22, 2007
  • Accepted May 2, 2007
  • Published online July 24, 2007.

Article Versions

  • Earlier version (May 2, 2007 - 09:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Maoqing Dong,
  2. Polo C.-H. Lam,
  3. Fan Gao,
  4. Keiko Hosohata,
  5. Delia I. Pinon,
  6. Patrick M. Sexton,
  7. Ruben Abagyan, and
  8. Laurence J. Miller
  1. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona (M.D., F.G., K.H., D.I.P., L.J.M.); Department of Molecular Biology, Scripps Research Institute and Molsoft LLC, La Jolla, California (P.C.-H.L., R.A.); and Department of Pharmacology, Monash University, Clayton, Victoria, Australia (P.M.S.)
  1. Address correspondence to:
    Laurence J. Miller, M.D., Mayo Clinic, 13400 East Shea Blvd., Scottsdale, AZ 85259. E-mail: miller{at}mayo.edu
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Molecular Pharmacology: 72 (2)
Molecular Pharmacology
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1 Aug 2007
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Research ArticleArticle

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

Maoqing Dong, Polo C.-H. Lam, Fan Gao, Keiko Hosohata, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan and Laurence J. Miller
Molecular Pharmacology August 1, 2007, 72 (2) 280-290; DOI: https://doi.org/10.1124/mol.107.035402

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Research ArticleArticle

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

Maoqing Dong, Polo C.-H. Lam, Fan Gao, Keiko Hosohata, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan and Laurence J. Miller
Molecular Pharmacology August 1, 2007, 72 (2) 280-290; DOI: https://doi.org/10.1124/mol.107.035402
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