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Molecular Pharmacology

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Research ArticleArticle

Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Carolina Simioni, Edward Leung, Stephen Maclennan, Pier Giovanni Baraldi and Pier Andrea Borea
Molecular Pharmacology August 2007, 72 (2) 395-406; DOI: https://doi.org/10.1124/mol.106.032920
Stefania Merighi
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Annalisa Benini
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Prisco Mirandola
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Stefania Gessi
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Katia Varani
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Carolina Simioni
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Edward Leung
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Stephen Maclennan
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Pier Giovanni Baraldi
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Pier Andrea Borea
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy (S.M., A.B., S.G., K.V., C.S., P.A.B.); Department of Human Anatomy, Pharmacology, and Forensic Medicine, Human Anatomy Section, University of Parma, Parma, Italy (P.M.); King Pharmaceuticals R&D, Cary, North Carolina (S.M.L., E.L.); Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy (P.G.B.); and Interdisciplinary Center for the Study of Inflammation, Ferrara, Italy (P.A.B.)
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Molecular Pharmacology: 72 (2)
Molecular Pharmacology
Vol. 72, Issue 2
1 Aug 2007
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Research ArticleArticle

Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Carolina Simioni, Edward Leung, Stephen Maclennan, Pier Giovanni Baraldi and Pier Andrea Borea
Molecular Pharmacology August 1, 2007, 72 (2) 395-406; DOI: https://doi.org/10.1124/mol.106.032920

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Research ArticleArticle

Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Carolina Simioni, Edward Leung, Stephen Maclennan, Pier Giovanni Baraldi and Pier Andrea Borea
Molecular Pharmacology August 1, 2007, 72 (2) 395-406; DOI: https://doi.org/10.1124/mol.106.032920
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