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Molecular Pharmacology

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Table of Contents

September 01, 2007; Volume 72,Issue 3

MINIREVIEW

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    The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems
    Brian J. McMillan and Christopher A. Bradfield
    Molecular Pharmacology September 2007, 72 (3) 487-498; DOI: https://doi.org/10.1124/mol.107.037259

Perspective

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    The MiRP2-Kv3.4 Potassium Channel: Muscling In on Alzheimer's Disease
    Eun Choi and Geoffrey W. Abbott
    Molecular Pharmacology September 2007, 72 (3) 499-501; DOI: https://doi.org/10.1124/mol.107.039206

Articles

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    Localization of the Mouse 5-Hydroxytryptamine1A Receptor in Lipid Microdomains Depends on Its Palmitoylation and Is Involved in Receptor-Mediated Signaling
    Ute Renner, Konstantin Glebov, Thorsten Lang, Ekaterina Papusheva, Saju Balakrishnan, Bernhard Keller, Diethelm W. Richter, Reinhard Jahn and Evgeni Ponimaskin
    Molecular Pharmacology September 2007, 72 (3) 502-513; DOI: https://doi.org/10.1124/mol.107.037085
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    Transcription Factor Binding to a Putative Double E-Box Motif Represses CYP3A4 Expression in Human Lung Cells
    Jason S. Biggs, Jie Wan, N. Shane Cutler, Jukka Hakkola, Päivi Uusimäki, Hannu Raunio and Garold S. Yost
    Molecular Pharmacology September 2007, 72 (3) 514-525; DOI: https://doi.org/10.1124/mol.106.033795
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    Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides
    Martin Göttle, Stefan Dove, Phillip Steindel, Yuequan Shen, Wei-Jen Tang, Jens Geduhn, Burkhard König and Roland Seifert
    Molecular Pharmacology September 2007, 72 (3) 526-535; DOI: https://doi.org/10.1124/mol.107.034413
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    The Impact of Hypoxic Treatment on the Expression of Phosphoglycerate Kinase and the Cytotoxicity of Troxacitabine and Gemcitabine
    Wing Lam, Chung-Hang Leung, Scott Bussom and Yung-Chi Cheng
    Molecular Pharmacology September 2007, 72 (3) 536-544; DOI: https://doi.org/10.1124/mol.106.033472
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    Philinopside E, a New Sulfated Saponin from Sea Cucumber, Blocks the Interaction between Kinase Insert Domain-Containing Receptor (KDR) and αvβ3 Integrin via Binding to the Extracellular Domain of KDR
    Fang Tian, Cai-hua Zhu, Xiong-wen Zhang, Xin Xie, Xian-liang Xin, Yang-hua Yi, Li-ping Lin, Mei-yu Geng and Jian Ding
    Molecular Pharmacology September 2007, 72 (3) 545-552; DOI: https://doi.org/10.1124/mol.107.036350
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    Dynamin 2 Regulates Riboflavin Endocytosis in Human Placental Trophoblasts
    Amy B. Foraker, Abhijit Ray, Tatiana Claro Da Silva, Lisa M. Bareford, Kathleen M. Hillgren, Thomas D. Schmittgen and Peter W. Swaan
    Molecular Pharmacology September 2007, 72 (3) 553-562; DOI: https://doi.org/10.1124/mol.107.037101
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    Structural Basis of Spirolactone Recognition by the Mineralocorticoid Receptor
    Jessica Huyet, Grégory M. Pinon, Michel R. Fay, Jérôme Fagart and Marie-Edith Rafestin-Oblin
    Molecular Pharmacology September 2007, 72 (3) 563-571; DOI: https://doi.org/10.1124/mol.107.036459
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    Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to “In Vivo” Biological Activity
    Géraldine Lemaire, Cindy Benod, Virginie Nahoum, Arnaud Pillon, Anne-Marie Boussioux, Jean-François Guichou, Guy Subra, Jean-Marc Pascussi, William Bourguet, Alain Chavanieu and Patrick Balaguer
    Molecular Pharmacology September 2007, 72 (3) 572-581; DOI: https://doi.org/10.1124/mol.106.033415
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    Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function
    Leif Erik Vinge, Kjetil W. Andressen, Toril Attramadal, Geir Øystein Andersen, Mohammed Shakil Ahmed, Karsten Peppel, Walter J. Koch, Neil J. Freedman, Finn Olav Levy, Tor Skomedal, Jan-Bjørn Osnes and Håvard Attramadal
    Molecular Pharmacology September 2007, 72 (3) 582-591; DOI: https://doi.org/10.1124/mol.107.035766
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    Human Pregnane X Receptor Antagonists and Agonists Define Molecular Requirements for Different Binding Sites
    Sean Ekins, Cheng Chang, Sridhar Mani, Matthew D. Krasowski, Erica J. Reschly, Manisha Iyer, Vladyslav Kholodovych, Ni Ai, William J. Welsh, Michael Sinz, Peter W. Swaan, Rachana Patel and Kenneth Bachmann
    Molecular Pharmacology September 2007, 72 (3) 592-603; DOI: https://doi.org/10.1124/mol.107.038398
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    The Human UDP-Glucuronosyltransferase: Identification of Key Residues within the Nucleotide-Sugar Binding Site
    Anne-Sisko Patana, Mika Kurkela, Adrian Goldman and Moshe Finel
    Molecular Pharmacology September 2007, 72 (3) 604-611; DOI: https://doi.org/10.1124/mol.107.036871
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    A Key Role for Diacylglycerol Lipase-α in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization
    Kwang-Mook Jung, Giuseppe Astarita, Chenggang Zhu, Matthew Wallace, Ken Mackie and Daniele Piomelli
    Molecular Pharmacology September 2007, 72 (3) 612-621; DOI: https://doi.org/10.1124/mol.107.037796
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    Interactions with Filamin A Stimulate Surface Expression of Large-Conductance Ca2+-Activated K+ Channels in the Absence of Direct Actin Binding
    Eun Young Kim, Lon D. Ridgway and Stuart E. Dryer
    Molecular Pharmacology September 2007, 72 (3) 622-630; DOI: https://doi.org/10.1124/mol.107.038026
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    A New Steroid Derivative Stabilizes G-Quadruplexes and Induces Telomere Uncapping in Human Tumor Cells
    Bertrand Brassart, Dennis Gomez, Anne De Cian, Rajaa Paterski, Alain Montagnac, Khuong-Huu Qui, Nassima Temime-Smaali, Chantal Trentesaux, Jean-Louis Mergny, Françoise Gueritte and Jean-François Riou
    Molecular Pharmacology September 2007, 72 (3) 631-640; DOI: https://doi.org/10.1124/mol.107.036574
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    The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing Epidermal Growth Factor Receptor
    K. To, Y. Zhao, H. Jiang, K. Hu, M. Wang, J. Wu, C. Lee, D. W. Yokom, A. L. Stratford, U. Klinge, P. R. Mertens, C. S. Chen, M. Bally, D. Yapp and S. E. Dunn
    Molecular Pharmacology September 2007, 72 (3) 641-652; DOI: https://doi.org/10.1124/mol.107.036111
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    Exacerbation of Dopaminergic Terminal Damage in a Mouse Model of Parkinson's Disease by the G-Protein-Coupled Receptor Protease-Activated Receptor 1
    Cecily E. Hamill, W. Michael Caudle, Jason R. Richardson, Hongjie Yuan, Kurt D. Pennell, James G. Greene, Gary W. Miller and Stephen F. Traynelis
    Molecular Pharmacology September 2007, 72 (3) 653-664; DOI: https://doi.org/10.1124/mol.107.038158
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    Up-Regulation and Increased Activity of KV3.4 Channels and Their Accessory Subunit MinK-Related Peptide 2 Induced by Amyloid Peptide Are Involved in Apoptotic Neuronal Death
    A. Pannaccione, F. Boscia, A. Scorziello, A. Adornetto, P. Castaldo, R. Sirabella, M. Taglialatela, G. F. Di Renzo and L. Annunziato
    Molecular Pharmacology September 2007, 72 (3) 665-673; DOI: https://doi.org/10.1124/mol.107.034868
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    Apoptotic Action of Peroxisome Proliferator-Activated Receptor-γ Activation in Human Non–Small-Cell Lung Cancer Is Mediated via Proline Oxidase-Induced Reactive Oxygen Species Formation
    Ki Young Kim, Jin Hee Ahn and Hyae Gyeong Cheon
    Molecular Pharmacology September 2007, 72 (3) 674-685; DOI: https://doi.org/10.1124/mol.107.035584
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    Interleukin-6 Alters the Cellular Responsiveness to Clopidogrel, Irinotecan, and Oseltamivir by Suppressing the Expression of Carboxylesterases HCE1 and HCE2
    Jian Yang, Deshi Shi, Dongfang Yang, Xiulong Song and Bingfang Yan
    Molecular Pharmacology September 2007, 72 (3) 686-694; DOI: https://doi.org/10.1124/mol.107.036889
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    Stromal Cell-Derived Factor-1 Induces Matrix Metalloprotease-13 Expression in Human Chondrocytes
    Yung-Cheng Chiu, Rong-Sen Yang, Kuo-Hsien Hsieh, Yi-Chin Fong, Tzong-Der Way, Tu-Sheng Lee, Hsi-Chin Wu, Wen-Mei Fu and Chih-Hsin Tang
    Molecular Pharmacology September 2007, 72 (3) 695-703; DOI: https://doi.org/10.1124/mol.107.036541
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    Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling
    Clint Mitchell, Peyman Kabolizadeh, John Ryan, John D. Roberts, Adly Yacoub, David T. Curiel, Paul B. Fisher, Michael P. Hagan, Nicholas P. Farrell, Steven Grant and Paul Dent
    Molecular Pharmacology September 2007, 72 (3) 704-714; DOI: https://doi.org/10.1124/mol.107.038406
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    Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
    Jens Halvard Grønlien, Monika Håkerud, Hilde Ween, Kirsten Thorin-Hagene, Clark A. Briggs, Murali Gopalakrishnan and John Malysz
    Molecular Pharmacology September 2007, 72 (3) 715-724; DOI: https://doi.org/10.1124/mol.107.035410
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    Thiazolidinediones Modulate the Expression of β-Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of Skp1-Cul1-F-box Protein E3 Ubiquitin Ligase Independently of Peroxisome Proliferator-Activated Receptor γ
    Shuo Wei, Li-Fang Lin, Chih-Cheng Yang, Yu-Chieh Wang, Geen-Dong Chang, Hungwen Chen and Ching-Shih Chen
    Molecular Pharmacology September 2007, 72 (3) 725-733; DOI: https://doi.org/10.1124/mol.107.035287
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    Functional Characterization of the Promoter of Human Carbonyl Reductase 1 (CBR1). Role of XRE Elements in Mediating the Induction of CBR1 by Ligands of the Aryl Hydrocarbon Receptor
    Sukhwinder S. Lakhman, Xiaomin Chen, Vanessa Gonzalez-Covarrubias, Erin G. Schuetz and Javier G. Blanco
    Molecular Pharmacology September 2007, 72 (3) 734-743; DOI: https://doi.org/10.1124/mol.107.035550
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    Perturbation of Dopamine Metabolism by 3-Amino-2-(4′-halophenyl)propenes Leads to Increased Oxidative Stress and Apoptotic SH-SY5Y Cell Death
    Warren C. Samms, Rohan P. Perera, D. S. Wimalasena and K. Wimalasena
    Molecular Pharmacology September 2007, 72 (3) 744-752; DOI: https://doi.org/10.1124/mol.107.035873
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    Phosphorylation of Gαs Influences Its Association with the μ-Opioid Receptor and Is Modulated by Long-Term Morphine Exposure
    Sumita Chakrabarti and Alan R. Gintzler
    Molecular Pharmacology September 2007, 72 (3) 753-760; DOI: https://doi.org/10.1124/mol.107.036145
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    Nicotine Glucuronidation and the Human UDP-Glucuronosyltransferase UGT2B10
    Sanna Kaivosaari, Päivi Toivonen, Leah M. Hesse, Mikko Koskinen, Michael H. Court and Moshe Finel
    Molecular Pharmacology September 2007, 72 (3) 761-768; DOI: https://doi.org/10.1124/mol.107.037093
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    Signaling Pathways Involved in Cyclooxygenase-2 Induction by Hepatocyte Growth Factor in Non–Small-Cell Lung Cancer
    Jill M. Siegfried, Christopher T. Gubish, Mary E. Rothstein, Pierre E. Queiroz de Oliveira and Laura P. Stabile
    Molecular Pharmacology September 2007, 72 (3) 769-779; DOI: https://doi.org/10.1124/mol.107.034215
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    Modulation of Presynaptic β3-Containing GABAA Receptors Limits the Immobilizing Actions of GABAergic Anesthetics
    Christian Grasshoff, Rachel Jurd, Uwe Rudolph and Bernd Antkowiak
    Molecular Pharmacology September 2007, 72 (3) 780-787; DOI: https://doi.org/10.1124/mol.107.037648
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    The Multikinase Inhibitor Sorafenib Induces Apoptosis in Highly Imatinib Mesylate-Resistant Bcr/Abl+ Human Leukemia Cells in Association with Signal Transducer and Activator of Transcription 5 Inhibition and Myeloid Cell Leukemia-1 Down-Regulation
    Mohamed Rahmani, Tri K. Nguyen, Paul Dent and Steven Grant
    Molecular Pharmacology September 2007, 72 (3) 788-795; DOI: https://doi.org/10.1124/mol.106.033308

Errata

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    Correction to “Chromanol 293B Binding in KCNQ1 (Kv7.1) Channels Involves Electrostatic Interactions with a Potassium Ion in the Selectivity Filter”
    Molecular Pharmacology September 2007, 72 (3) 796; DOI: https://doi.org/10.1124/mol.72.3.796
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    Correction to “Phoneutria nigriventer Toxin 1: A Novel, State-Dependent Inhibitor of Neuronal Sodium Channels That Interacts with μ Conotoxin Binding Sites”
    Molecular Pharmacology September 2007, 72 (3) 797; DOI: https://doi.org/10.1124/mol.72.3.797
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Molecular Pharmacology: 72 (3)
Molecular Pharmacology
Vol. 72, Issue 3
1 Sep 2007
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