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Molecular Pharmacology

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Table of Contents

October 01, 2007; Volume 72,Issue 4

MINIREVIEW

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    Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?
    Robert Newton and Neil S. Holden
    Molecular Pharmacology October 2007, 72 (4) 799-809; DOI: https://doi.org/10.1124/mol.107.038794

Perspective

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    Illuminating Gβ5 Signaling
    Corinne E. Zeller and Henrik G. Dohlman
    Molecular Pharmacology October 2007, 72 (4) 810-811; DOI: https://doi.org/10.1124/mol.107.040055

Articles

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    Live Cell Analysis of G Protein β5 Complex Formation, Function, and Targeting
    Evan A. Yost, Stacy M. Mervine, Jonathan L. Sabo, Thomas R. Hynes and Catherine H. Berlot
    Molecular Pharmacology October 2007, 72 (4) 812-825; DOI: https://doi.org/10.1124/mol.107.038075
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    Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-Responsive Enhancer Binding Protein (Nuclear Factor of Activated T Cells 5)
    Kazuhiro Kosuge, Andrew I. Chuang, Satoko Uematsu, Kah Poh Tan, Kyoichi Ohashi, Ben C.B. Ko and Shinya Ito
    Molecular Pharmacology October 2007, 72 (4) 826-837; DOI: https://doi.org/10.1124/mol.107.034504
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    Structural Determinates for Apolipoprotein E-Derived Peptide Interaction with the α7 Nicotinic Acetylcholine Receptor
    Elaine A. Gay, Rachelle J. Bienstock, Patricia W. Lamb and Jerrel L. Yakel
    Molecular Pharmacology October 2007, 72 (4) 838-849; DOI: https://doi.org/10.1124/mol.107.035527
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    Insulin Facilitates the Hepatic Clearance of Plasma Amyloid β-Peptide (1–40) by Intracellular Translocation of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP-1) to the Plasma Membrane in Hepatocytes
    Chihiro Tamaki, Sumio Ohtsuki and Tetsuya Terasaki
    Molecular Pharmacology October 2007, 72 (4) 850-855; DOI: https://doi.org/10.1124/mol.107.036913
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    Activation of the Adenosine A1 Receptor Inhibits HIV-1 Tat-Induced Apoptosis by Reducing Nuclear Factor-κB Activation and Inducible Nitric-Oxide Synthase
    Sandeep C. Pingle, Sarvesh Jajoo, Debashree Mukherjea, Lynn F. Sniderhan, Krishna A. Jhaveri, Adriana Marcuzzi, Leonard P. Rybak, Sanjay B. Maggirwar and Vickram Ramkumar
    Molecular Pharmacology October 2007, 72 (4) 856-867; DOI: https://doi.org/10.1124/mol.106.031427
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    Application of β-Lactamase Enzyme Complementation to the High-Throughput Screening of Toll-Like Receptor Signaling Inhibitors
    Hyun-Ku Lee, Steven J. Brown, Hugh Rosen and Peter S. Tobias
    Molecular Pharmacology October 2007, 72 (4) 868-875; DOI: https://doi.org/10.1124/mol.107.038349
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    Identification of a Bis-guanylhydrazone [4,4′-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase
    Andrew G. Jobson, John H. Cardellina, Dominic Scudiero, Sudhir Kondapaka, Hongliang Zhang, Hijoo Kim, Robert Shoemaker and Yves Pommier
    Molecular Pharmacology October 2007, 72 (4) 876-884; DOI: https://doi.org/10.1124/mol.107.035832
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    Serotonin 5-Hydroxytryptamine2C Receptor Signaling in Hypothalamic Proopiomelanocortin Neurons: Role in Energy Homeostasis in Females
    Jian Qiu, Changhui Xue, Martha A. Bosch, Jonathan G. Murphy, Wei Fan, Oline K. Rønnekleiv and Martin J. Kelly
    Molecular Pharmacology October 2007, 72 (4) 885-896; DOI: https://doi.org/10.1124/mol.107.038083
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    Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action
    Stephen J. Gardell, Julie A. Krueger, Thomas A. Antrilli, Hassan Elokdah, Scott Mayer, Steven J. Orcutt, David L. Crandall and George P. Vlasuk
    Molecular Pharmacology October 2007, 72 (4) 897-906; DOI: https://doi.org/10.1124/mol.107.037010
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    Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors
    Kevin Erreger, Matthew T. Geballe, Anders Kristensen, Philip E. Chen, Kasper B. Hansen, C. Justin Lee, Hongjie Yuan, Phuong Le, Polina N. Lyuboslavsky, Nicola Micale, Lars Jørgensen, Rasmus P. Clausen, David J. A. Wyllie, James P. Snyder and Stephen F. Traynelis
    Molecular Pharmacology October 2007, 72 (4) 907-920; DOI: https://doi.org/10.1124/mol.107.037333
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    Identification of Regions of the σ-1 Receptor Ligand Binding Site Using a Novel Photoprobe
    Arindam Pal, Abdol R. Hajipour, Dominique Fontanilla, Subramaniam Ramachandran, Uyen B. Chu, Timur Mavlyutov and Arnold E. Ruoho
    Molecular Pharmacology October 2007, 72 (4) 921-933; DOI: https://doi.org/10.1124/mol.107.038307
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    Gemfibrozil Ameliorates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Independent of Peroxisome Proliferator-Activated Receptor-α
    Subhajit Dasgupta, Avik Roy, Malabendu Jana, Dean M. Hartley and Kalipada Pahan
    Molecular Pharmacology October 2007, 72 (4) 934-946; DOI: https://doi.org/10.1124/mol.106.033787
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    Physiological Differences between Human and Rat Primary Hepatocytes in Response to Liver X Receptor Activation by 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic Acid Hydrochloride (GW3965)
    Pia Kotokorpi, Ewa Ellis, Paolo Parini, Lisa-Mari Nilsson, Stephen Strom, Knut R. Steffensen, Jan-Åke Gustafsson and Agneta Mode
    Molecular Pharmacology October 2007, 72 (4) 947-955; DOI: https://doi.org/10.1124/mol.107.037358
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    Aryl Hydrocarbon Receptor Splice Variants in the Dioxin-Resistant Rat: Tissue Expression and Transactivational Activity
    Ivy D. Moffat, Steven Roblin, Patricia A. Harper, Allan B. Okey and Raimo Pohjanvirta
    Molecular Pharmacology October 2007, 72 (4) 956-966; DOI: https://doi.org/10.1124/mol.107.037218
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    Effect of Breast Cancer Resistance Protein (Bcrp/Abcg2) on the Disposition of Phytoestrogens
    Junichi Enokizono, Hiroyuki Kusuhara and Yuichi Sugiyama
    Molecular Pharmacology October 2007, 72 (4) 967-975; DOI: https://doi.org/10.1124/mol.107.034751
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    Pharmacological Characterization of a Novel Nonpeptide Antagonist for Formyl Peptide Receptor-Like 1
    Caihong Zhou, Song Zhang, Masakatsu Nanamori, Yueyun Zhang, Qing Liu, Na Li, Meiling Sun, Jun Tian, Patrick P. Ye, Ni Cheng, Richard D. Ye and Ming-Wei Wang
    Molecular Pharmacology October 2007, 72 (4) 976-983; DOI: https://doi.org/10.1124/mol.107.037564
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    Antithrombotic Effect of a Protein-Type I Class Snake Venom Metalloproteinase, Kistomin, Is Mediated by Affecting Glycoprotein Ib-von Willebrand Factor Interaction
    Chun-Chieh Hsu, Wen-Bin Wu, Ya-Hui Chang, Heng-Lan Kuo and Tur-Fu Huang
    Molecular Pharmacology October 2007, 72 (4) 984-992; DOI: https://doi.org/10.1124/mol.107.038018
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    Disruption of Oligomerization Induces Nucleocytoplasmic Shuttling of Leukemia-Associated Rho Guanine-Nucleotide Exchange Factor
    Elda Grabocka and Philip B. Wedegaertner
    Molecular Pharmacology October 2007, 72 (4) 993-1002; DOI: https://doi.org/10.1124/mol.107.035162
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    A Mouse Model for Studying the Interaction of Bisdioxopiperazines with Topoisomerase IIα in Vivo
    Morten Grauslund, Annemette Vinding Thougaard, Annette Füchtbauer, Kenneth Francis Hofland, Peter Hansen Hjorth, Peter B. Jensen, Maxwell Sehested, Ernst-Martin Füchtbauer and Lars H. Jensen
    Molecular Pharmacology October 2007, 72 (4) 1003-1014; DOI: https://doi.org/10.1124/mol.107.036970
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    γ-Glutamylcysteine Synthetase Mediates the c-Myc-Dependent Response to Antineoplastic Agents in Melanoma Cells
    Barbara Benassi, Gabriella Zupi and Annamaria Biroccio
    Molecular Pharmacology October 2007, 72 (4) 1015-1023; DOI: https://doi.org/10.1124/mol.107.038687
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    The Endocannabinoid Anandamide Inhibits the Function of α4β2 Nicotinic Acetylcholine Receptors
    Charles E. Spivak, Carl R. Lupica and Murat Oz
    Molecular Pharmacology October 2007, 72 (4) 1024-1032; DOI: https://doi.org/10.1124/mol.107.036939
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    The Small Molecule NS11021 Is a Potent and Specific Activator of Ca2+-Activated Big-Conductance K+ Channels
    Bo Hjorth Bentzen, Antonio Nardi, Kirstine Calloe, Lars Siim Madsen, Søren-Peter Olesen and Morten Grunnet
    Molecular Pharmacology October 2007, 72 (4) 1033-1044; DOI: https://doi.org/10.1124/mol.107.038331
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    Down-Regulation of Pregnane X Receptor Contributes to Cell Growth Inhibition and Apoptosis by Anticancer Agents in Endometrial Cancer Cells
    Hisashi Masuyama, Hideki Nakatsukasa, Norio Takamoto and Yuji Hiramatsu
    Molecular Pharmacology October 2007, 72 (4) 1045-1053; DOI: https://doi.org/10.1124/mol.107.037937
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    Critical Roles of Residues 36 and 40 in the Phenol and Tertiary Amine Aglycone Substrate Selectivities of UDP-Glucuronosyltransferases 1A3 and 1A4
    Takahiro Kubota, Benjamin C. Lewis, David J. Elliot, Peter I. Mackenzie and John O. Miners
    Molecular Pharmacology October 2007, 72 (4) 1054-1062; DOI: https://doi.org/10.1124/mol.107.037952
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    Electrophysiological Properties of Cardiomyocytes Isolated from CYP2J2 Transgenic Mice
    Qingen Ke, Yong-Fu Xiao, J. Alyce Bradbury, Joan P. Graves, Laura M. DeGraff, John M. Seubert and Darryl C. Zeldin
    Molecular Pharmacology October 2007, 72 (4) 1063-1073; DOI: https://doi.org/10.1124/mol.107.035881
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    Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants
    Sally E. Purdom-Dickinson, Elena V. Sheveleva, Haipeng Sun and Qin M. Chen
    Molecular Pharmacology October 2007, 72 (4) 1074-1081; DOI: https://doi.org/10.1124/mol.107.035360
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    Induction of Glutathione Transferase in Insulin-Like Growth Factor Type I Receptor-Overexpressed Hepatoma Cells
    Jeong Yong Lee, Chang Yeob Han, Jin Won Yang, Christopher Smith, Sang Kyum Kim, Eva Y.-H. P. Lee, Sang Geon Kim and Keon Wook Kang
    Molecular Pharmacology October 2007, 72 (4) 1082-1093; DOI: https://doi.org/10.1124/mol.107.038174

Errata

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    Correction to “Molecular Aspects of Antitumor Effects of a New Platinum(IV) Drug”
    Molecular Pharmacology October 2007, 72 (4) 1094; DOI: https://doi.org/10.1124/mol.72.4.1094
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    Correction to “Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8”
    Molecular Pharmacology October 2007, 72 (4) 1095; DOI: https://doi.org/10.1124/mol.72.4.1095
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In this issue

Molecular Pharmacology: 72 (4)
Molecular Pharmacology
Vol. 72, Issue 4
1 Oct 2007
  • Table of Contents
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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