Table of Contents

Articles

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  Regulation of Glutathione Synthesis via Interaction between Glutamate Transport-Associated Protein 3-18 (GTRAP3-18) and Excitatory Amino Acid Carrier-1 (EAAC1) at Plasma Membrane

  Masahiko Watabe, Koji Aoyama and Toshio Nakaki

  Molecular Pharmacology November 2007, 72 (5) 1103-1110; DOI: https://doi.org/10.1124/mol.107.039461
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  Identification of Two New Synthetic Histone Deacetylase Inhibitors That Modulate Globin Gene Expression in Erythroid Cells from Healthy Donors and Patients with Thalassemia

  Antonello Mai, Katija Jelicic, Dante Rotili, Antonella Di Noia, Elena Alfani, Sergio Valente, Lucia Altucci, Angela Nebbioso, Silvio Massa, Renzo Galanello, Gerald Brosch, Anna Rita Migliaccio and Giovanni Migliaccio

  Molecular Pharmacology November 2007, 72 (5) 1111-1123; DOI: https://doi.org/10.1124/mol.107.036772
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  2-Amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} Acetamide (OSU-03012), a Celecoxib Derivative, Directly Targets p21-Activated Kinase

  Leonardo M. Porchia, Marcy Guerra, Yu-Chieh Wang, Yunlong Zhang, Allan V. Espinosa, Motoo Shinohara, Samuel K. Kulp, Lawrence S. Kirschner, Motoyasu Saji, Ching-Shih Chen and Matthew D. Ringel

  Molecular Pharmacology November 2007, 72 (5) 1124-1131; DOI: https://doi.org/10.1124/mol.107.037556
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  Purinergic 2X₁ Receptors Mediate Endothelial Dependent Vasodilation to ATP

  L. S. Harrington, R. J. Evans, J. Wray, L. Norling, K. E. Swales, C. Vial, F. Ali, M. J. Carrier and J. A. Mitchell

  Molecular Pharmacology November 2007, 72 (5) 1132-1136; DOI: https://doi.org/10.1124/mol.107.037325
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  8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells

  Zhenfeng Duan, James Bradner, Edward Greenberg, Ralph Mazitschek, Rosemary Foster, Jennifer Mahoney and Michael V. Seiden

  Molecular Pharmacology November 2007, 72 (5) 1137-1145; DOI: https://doi.org/10.1124/mol.107.038117
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  Capacitative Calcium Entry Contributes to the Differential Transactivation of the Epidermal Growth Factor Receptor in Response to Thiazolidinediones

  Brian J. Dewar, Olivia S. Gardner, Ching-Shih Chen, H. Shelton Earp, James M. Samet and Lee M. Graves

  Molecular Pharmacology November 2007, 72 (5) 1146-1156; DOI: https://doi.org/10.1124/mol.107.037549
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  Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1

  Michael M. C. Kong, Ahmed Hasbi, Michael Mattocks, Theresa Fan, Brian F. O'Dowd and Susan R. George

  Molecular Pharmacology November 2007, 72 (5) 1157-1170; DOI: https://doi.org/10.1124/mol.107.034769
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  Evaluation of Action Mechanisms of Toxic Chemicals Using JFCR39, a Panel of Human Cancer Cell Lines

  Noriyuki Nakatsu, Tomoki Nakamura, Kanami Yamazaki, Soutaro Sadahiro, Hiroyasu Makuuchi, Jun Kanno and Takao Yamori

  Molecular Pharmacology November 2007, 72 (5) 1171-1180; DOI: https://doi.org/10.1124/mol.107.038836
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  Dimerization Region of Soluble Guanylate Cyclase Characterized by Bimolecular Fluorescence Complementation in Vivo

  Christiane Rothkegel, Peter M. Schmidt, Derek-John Atkins, Linda Sarah Hoffmann, Harald H. H. W. Schmidt, Henning Schröder and Johannes-Peter Stasch

  Molecular Pharmacology November 2007, 72 (5) 1181-1190; DOI: https://doi.org/10.1124/mol.107.036368
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  Rational Engineering of Human Cytochrome P450 2B6 for Enhanced Expression and Stability: Importance of a Leu²⁶⁴→Phe Substitution

  Santosh Kumar, Yonghong Zhao, Ling Sun, Surendra S. Negi, James R. Halpert and B. K. Muralidhara

  Molecular Pharmacology November 2007, 72 (5) 1191-1199; DOI: https://doi.org/10.1124/mol.107.039693
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  Assessment of the Roles of Serines 5.43(239) and 5.46(242) for Binding and Potency of Agonist Ligands at the Human Serotonin 5-HT_2A Receptor

  Michael R. Braden and David E. Nichols

  Molecular Pharmacology November 2007, 72 (5) 1200-1209; DOI: https://doi.org/10.1124/mol.107.039255
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  Gβγ Interferes with Ca²⁺-Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex

  Eun-Ja Yoon, Tatyana Gerachshenko, Bryan D. Spiegelberg, Simon Alford and Heidi E. Hamm

  Molecular Pharmacology November 2007, 72 (5) 1210-1219; DOI: https://doi.org/10.1124/mol.107.039446
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  Mammalian Skeletal Muscle Voltage-Gated Sodium Channels Are Affected by Scorpion Depressant “Insect-Selective” Toxins when Preconditioned

  Lior Cohen, Yael Troub, Michael Turkov, Nicolas Gilles, Nitza Ilan, Morris Benveniste, Dalia Gordon and Michael Gurevitz

  Molecular Pharmacology November 2007, 72 (5) 1220-1227; DOI: https://doi.org/10.1124/mol.107.039057
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  Enhancing Glutamate Transport: Mechanism of Action of Parawixin1, a Neuroprotective Compound from Parawixia bistriata Spider Venom

  Andréia Cristina Karklin Fontana, Renê de Oliveira Beleboni, Marcin Włodzimierz Wojewodzic, Wagner Ferreira dos Santos, Joaquim Coutinho-Netto, Nina Julie Grutle, Spencer D. Watts, Niels Christian Danbolt and Susan G. Amara

  Molecular Pharmacology November 2007, 72 (5) 1228-1237; DOI: https://doi.org/10.1124/mol.107.037127
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  Peroxisomal Proliferator-Activated Receptor-α Protects Renal Tubular Cells from Doxorubicin-Induced Apoptosis

  Heng Lin, Chun-Cheng Hou, Ching-Feng Cheng, Ted-H. Chiu, Yung-Ho Hsu, Yuh-Mou Sue, Tso-Hsiao Chen, Hsin-Han Hou, Ying-Chi Chao, Tzu-Hurng Cheng and Cheng-Hsien Chen

  Molecular Pharmacology November 2007, 72 (5) 1238-1245; DOI: https://doi.org/10.1124/mol.107.037523
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  Inhibition of Trail Gene Expression by Cyclopentenonic Prostaglandin 15-Deoxy-Δ^12,14-Prostaglandin J₂ in T Lymphocytes

  Cinzia Fionda, Filomena Nappi, Mario Piccoli, Luigi Frati, Angela Santoni and Marco Cippitelli

  Molecular Pharmacology November 2007, 72 (5) 1246-1257; DOI: https://doi.org/10.1124/mol.107.038042
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  Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Borate

  Véronique Juvin, Aubin Penna, Jean Chemin, Yea-Lih Lin and François-A. Rassendren

  Molecular Pharmacology November 2007, 72 (5) 1258-1268; DOI: https://doi.org/10.1124/mol.107.037044
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  CCAAT/Enhancer Binding Protein Homologous Protein-Dependent Death Receptor 5 Induction and Ubiquitin/Proteasome-Mediated Cellular FLICE-Inhibitory Protein Down-Regulation Contribute to Enhancement of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Dimethyl-Celecoxib in Human Non–Small-Cell Lung Cancer Cells

  Shuzhen Chen, Xiangguo Liu, Ping Yue, Axel H. Schönthal, Fadlo R. Khuri and Shi-Yong Sun

  Molecular Pharmacology November 2007, 72 (5) 1269-1279; DOI: https://doi.org/10.1124/mol.107.037465
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  Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity

  Lian Wei, Charles W. Locuson and Timothy S. Tracy

  Molecular Pharmacology November 2007, 72 (5) 1280-1288; DOI: https://doi.org/10.1124/mol.107.036178
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  Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 in Migration Signaling of a G Protein-Coupled Receptor

  Fang He, Zhuan-Hong Qiao, Jian Cai, William Pierce, Da-Cheng He and Zhao-Hui Song

  Molecular Pharmacology November 2007, 72 (5) 1289-1300; DOI: https://doi.org/10.1124/mol.107.036566
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  Role of Protein Kinase Cζ and Its Adaptor Protein p62 in Voltage-Gated Potassium Channel Modulation in Pulmonary Arteries

  Laura Moreno, Giovanna Frazziano, Angel Cogolludo, Laura Cobeño, Juan Tamargo and Francisco Perez-Vizcaino

  Molecular Pharmacology November 2007, 72 (5) 1301-1309; DOI: https://doi.org/10.1124/mol.107.037002
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  Association of Nucleophosmin Negatively Regulates CXCR4-Mediated G Protein Activation and Chemotaxis

  Wenbo Zhang, Jean-Marc Navenot, Nicole M. Frilot, Nobutaka Fujii and Stephen C. Peiper

  Molecular Pharmacology November 2007, 72 (5) 1310-1321; DOI: https://doi.org/10.1124/mol.107.037119
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  The Neurosteroids Dehydroepiandrosterone Sulfate and Pregnenolone Sulfate Inhibit the UNC-49 GABA Receptor through a Common Set of Residues

  Vernon Twede, Anthony L. Tartaglia, Douglas F. Covey and Bruce A. Bamber

  Molecular Pharmacology November 2007, 72 (5) 1322-1329; DOI: https://doi.org/10.1124/mol.107.034058
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  Inhibition of the Na⁺/Dicarboxylate Cotransporter by Anthranilic Acid Derivatives

  Ana M. Pajor and Kathleen M. Randolph

  Molecular Pharmacology November 2007, 72 (5) 1330-1336; DOI: https://doi.org/10.1124/mol.107.035352
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  Geranylgeranylacetone, an Inducer of the 70-kDa Heat Shock Protein (HSP70), Elicits Unfolded Protein Response and Coordinates Cellular Fate Independently of HSP70

  Satoshi Endo, Nobuhiko Hiramatsu, Kunihiro Hayakawa, Maro Okamura, Ayumi Kasai, Yasuhiro Tagawa, Norifumi Sawada, Jian Yao and Masanori Kitamura

  Molecular Pharmacology November 2007, 72 (5) 1337-1348; DOI: https://doi.org/10.1124/mol.107.039164
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  Disruption of Clock Gene Expression Alters Responses of the Aryl Hydrocarbon Receptor Signaling Pathway in the Mouse Mammary Gland

  Xiaoyu Qu, Richard P. Metz, Weston W. Porter, Vincent M. Cassone and David J. Earnest

  Molecular Pharmacology November 2007, 72 (5) 1349-1358; DOI: https://doi.org/10.1124/mol.107.039305
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  Ligand-Directed Signaling at the β₃-Adrenoceptor Produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) Relative to Receptor Agonists

  Masaaki Sato, Takahiro Horinouchi, Dana S. Hutchinson, Bronwyn A. Evans and Roger J. Summers

  Molecular Pharmacology November 2007, 72 (5) 1359-1368; DOI: https://doi.org/10.1124/mol.107.035337
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  Evidence for an Aryl Hydrocarbon Receptor-Mediated Cytochrome P450 Autoregulatory Pathway

  Christopher R. Chiaro, Rushang D. Patel, Craig B. Marcus and Gary H. Perdew

  Molecular Pharmacology November 2007, 72 (5) 1369-1379; DOI: https://doi.org/10.1124/mol.107.038968
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  Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of Oxidative Stress

  Kah Poh Tan, Mingdong Yang and Shinya Ito

  Molecular Pharmacology November 2007, 72 (5) 1380-1390; DOI: https://doi.org/10.1124/mol.107.039370