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Molecular Pharmacology

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Table of Contents

December 01, 2007; Volume 72,Issue 6

MINIREVIEW

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    Functional Selectivity through Protean and Biased Agonism: Who Steers the Ship?
    Terry Kenakin
    Molecular Pharmacology December 2007, 72 (6) 1393-1401; DOI: https://doi.org/10.1124/mol.107.040352

Perspective

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    Go It Alone No More—P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels
    George R. Dubyak
    Molecular Pharmacology December 2007, 72 (6) 1402-1405; DOI: https://doi.org/10.1124/mol.107.042077

Accelerated Communications

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    Are α9α10 Nicotinic Acetylcholine Receptors a Pain Target for α-Conotoxins?
    S. T. Nevin, R. J. Clark, H. Klimis, M. J. Christie, D. J. Craik and D. J. Adams
    Molecular Pharmacology December 2007, 72 (6) 1406-1410; DOI: https://doi.org/10.1124/mol.107.040568
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    Substance P Neurokinin 1 Receptor Activation within the Dorsal Raphe Nucleus Controls Serotonin Release in the Mouse Frontal Cortex
    Bruno P. Guiard, Jean-Philippe Guilloux, Christelle Reperant, Stephen P. Hunt, Miklos Toth and Alain M. Gardier
    Molecular Pharmacology December 2007, 72 (6) 1411-1418; DOI: https://doi.org/10.1124/mol.107.040113
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    In Vivo Oxidative Damage in Rats Is Associated with Barbiturate Response but Not Other Cytochrome P450 Inducers
    Miroslav Dostalek, Joshua D. Brooks, Klarissa D. Hardy, Ginger L. Milne, Megan M. Moore, Sameer Sharma, Jason D. Morrow and F. Peter Guengerich
    Molecular Pharmacology December 2007, 72 (6) 1419-1424; DOI: https://doi.org/10.1124/mol.107.040238

Articles

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    Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II
    Annie Quan, Andrew B. McGeachie, Damien J. Keating, Ellen M. van Dam, Jenny Rusak, Ngoc Chau, Chandra S. Malladi, Chen Chen, Adam McCluskey, Michael A. Cousin and Phillip J. Robinson
    Molecular Pharmacology December 2007, 72 (6) 1425-1439; DOI: https://doi.org/10.1124/mol.107.034207
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    Monitoring Interactions between Receptor Tyrosine Kinases and Their Downstream Effector Proteins in Living Cells Using Bioluminescence Resonance Energy Transfer
    Philip K. Tan, Jean Wang, Pey-Lih H. Littler, Kenneth K. Wong, Timothy A. Sweetnam, William Keefe, Norman R. Nash, Esther C. Reding, Fabrice Piu, Mark R. Brann and Hans H. Schiffer
    Molecular Pharmacology December 2007, 72 (6) 1440-1446; DOI: https://doi.org/10.1124/mol.107.039636
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    Evidence for Functional P2X4/P2X7 Heteromeric Receptors
    Chang Guo, Marianela Masin, Omar S. Qureshi and Ruth D. Murrell-Lagnado
    Molecular Pharmacology December 2007, 72 (6) 1447-1456; DOI: https://doi.org/10.1124/mol.107.035980
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    A Dioxin-Responsive Enhancer 3′ of the Human CYP1A2 Gene
    Steven T. Okino, Linda C. Quattrochi, Deepa Pookot, Mieko Iwahashi and Rajvir Dahiya
    Molecular Pharmacology December 2007, 72 (6) 1457-1465; DOI: https://doi.org/10.1124/mol.107.039826
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    Mitochondria, Calcium, and Calpain are Key Mediators of Resveratrol-Induced Apoptosis in Breast Cancer
    Dhruv Sareen, Soesiawati R. Darjatmoko, Daniel M. Albert and Arthur S. Polans
    Molecular Pharmacology December 2007, 72 (6) 1466-1475; DOI: https://doi.org/10.1124/mol.107.039040
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    Transforming Growth Factor-β1 Impairs Endothelin-1-Mediated Contraction of Brain Vessels by Inducing Mitogen-Activated Protein (MAP) Kinase Phosphatase-1 and Inhibiting p38 MAP Kinase
    Xin-Kang Tong and Edith Hamel
    Molecular Pharmacology December 2007, 72 (6) 1476-1483; DOI: https://doi.org/10.1124/mol.107.039602
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    Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands
    J. Alex Goodwin, Edward C. Hulme, Christopher J. Langmead and Ben G. Tehan
    Molecular Pharmacology December 2007, 72 (6) 1484-1496; DOI: https://doi.org/10.1124/mol.107.038265
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    Identification of a Postendocytic Sorting Sequence in CCR5
    Maurine Delhaye, Audrey Gravot, Diana Ayinde, Florence Niedergang, Marc Alizon and Anne Brelot
    Molecular Pharmacology December 2007, 72 (6) 1497-1507; DOI: https://doi.org/10.1124/mol.107.038422
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    Resveratrol (trans-3,5,4′-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving Activation of Aryl Hydrocarbon Receptor and Estrogen Receptor
    Narendra P. Singh, Venkatesh L. Hegde, Lorne J. Hofseth, Mitzi Nagarkatti and Prakash Nagarkatti
    Molecular Pharmacology December 2007, 72 (6) 1508-1521; DOI: https://doi.org/10.1124/mol.107.038984
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    The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels
    Jodene Eldstrom, Zhuren Wang, Hongjian Xu, Marc Pourrier, Alan Ezrin, Ken Gibson and David Fedida
    Molecular Pharmacology December 2007, 72 (6) 1522-1534; DOI: https://doi.org/10.1124/mol.107.039388
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    The N-Terminal Domains of both NR1 and NR2 Subunits Determine Allosteric Zn2+ Inhibition and Glycine Affinity of N-Methyl-d-aspartate Receptors
    Christian Madry, Ivana Mesic, Heinrich Betz and Bodo Laube
    Molecular Pharmacology December 2007, 72 (6) 1535-1544; DOI: https://doi.org/10.1124/mol.107.040071
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    Docosahexaenoic Acid Induces Increases in [Ca2+]i via Inositol 1,4,5-Triphosphate Production and Activates Protein Kinase Cγ and -δ via Phosphatidylserine Binding Site: Implication in Apoptosis in U937 Cells
    Virginie Aires, Aziz Hichami, Rodolphe Filomenko, Aude Plé, Cédric Rébé, Ali Bettaieb and Naim Akhtar Khan
    Molecular Pharmacology December 2007, 72 (6) 1545-1556; DOI: https://doi.org/10.1124/mol.107.039792
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    CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a
    Jason L. Niehaus, Yunguang Liu, Kathleen T. Wallis, Michaela Egertová, Sheela G. Bhartur, Somnath Mukhopadhyay, Shanping Shi, Hengjun He, Dana E. Selley, Allyn C. Howlett, Maurice R. Elphick and Deborah L. Lewis
    Molecular Pharmacology December 2007, 72 (6) 1557-1566; DOI: https://doi.org/10.1124/mol.107.039263
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    Identification of the Substrate Binding Region of Vesicular Monoamine Transporter-2 (VMAT-2) Using Iodoaminoflisopolol as a Novel Photoprobe
    Anupama Gopalakrishnan, Michael Sievert and Arnold E. Ruoho
    Molecular Pharmacology December 2007, 72 (6) 1567-1575; DOI: https://doi.org/10.1124/mol.107.034439
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    Inhibition of TRPP3 Channel by Amiloride and Analogs
    Xiao-Qing Dai, Alkarim Ramji, Yan Liu, Qiang Li, Edward Karpinski and Xing-Zhen Chen
    Molecular Pharmacology December 2007, 72 (6) 1576-1585; DOI: https://doi.org/10.1124/mol.107.037150
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    Aspirin Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-Regulation
    Jinsang Yoo and Yong J. Lee
    Molecular Pharmacology December 2007, 72 (6) 1586-1592; DOI: https://doi.org/10.1124/mol.107.039610
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    Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase
    Nicola Solaroli, Xinyu Zheng, Magnus Johansson, Jan Balzarini and Anna Karlsson
    Molecular Pharmacology December 2007, 72 (6) 1593-1598; DOI: https://doi.org/10.1124/mol.107.037051
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    Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of β-Catenin
    Gyu-Yong Song, Jee-Hyun Lee, Munju Cho, Byeoung-Soo Park, Dong-Eun Kim and Sangtaek Oh
    Molecular Pharmacology December 2007, 72 (6) 1599-1606; DOI: https://doi.org/10.1124/mol.107.040253
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    K252a Prevents Nigral Dopaminergic Cell Death Induced by 6-Hydroxydopamine through Inhibition of Both Mixed-Lineage Kinase 3/c-Jun NH2-Terminal Kinase 3 (JNK3) and Apoptosis-Inducing Kinase 1/JNK3 Signaling Pathways
    Jing Pan, Gang Wang, Hong-Qi Yang, Zhen Hong, Qin Xiao, Ru-Jing Ren, Hai-Yan Zhou, Li Bai and Sheng-Di Chen
    Molecular Pharmacology December 2007, 72 (6) 1607-1618; DOI: https://doi.org/10.1124/mol.107.038463
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    Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation
    Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Insook Kim, Kunio Shiota, Frank J. Gonzalez and Yuichi Sugiyama
    Molecular Pharmacology December 2007, 72 (6) 1619-1625; DOI: https://doi.org/10.1124/mol.107.039701
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    Adenosine A2A Receptor Occupancy Stimulates Collagen Expression by Hepatic Stellate Cells via Pathways Involving Protein Kinase A, Src, and Extracellular Signal-Regulated Kinases 1/2 Signaling Cascade or p38 Mitogen-Activated Protein Kinase Signaling Pathway
    Jiantu Che, Edwin S. L. Chan and Bruce N. Cronstein
    Molecular Pharmacology December 2007, 72 (6) 1626-1636; DOI: https://doi.org/10.1124/mol.107.038760
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    Cystine-Glutamate Transporter SLC7A11 Mediates Resistance to Geldanamycin but Not to 17-(Allylamino)-17-demethoxygeldanamycin
    Ruqing Liu, Paul E. Blower, Anh-Nhan Pham, Jialong Fang, Zunyan Dai, Carolyn Wise, Bridgette Green, Candee H. Teitel, Baitang Ning, Wenhua Ling, Beverly D. Lyn-Cook, Fred F. Kadlubar, Wolfgang Sadée and Ying Huang
    Molecular Pharmacology December 2007, 72 (6) 1637-1646; DOI: https://doi.org/10.1124/mol.107.039644
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    Repression of T-Cell Function by Thionamides Is Mediated by Inhibition of the Activator Protein-1/Nuclear Factor of Activated T-Cells Pathway and Is Associated with a Common Structure
    Matjaz Humar, Hannah Dohrmann, Philipp Stein, Nikolaos Andriopoulos, Ulrich Goebel, Bernd Heimrich, Martin Roesslein, Rene Schmidt, Christian I. Schwer, Alexander Hoetzel, Torsten Loop, Heike L. Pahl, Klaus K. Geiger and Benedikt H. J. Pannen
    Molecular Pharmacology December 2007, 72 (6) 1647-1656; DOI: https://doi.org/10.1124/mol.107.038141
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    Incensole Acetate, a Novel Anti-Inflammatory Compound Isolated from Boswellia Resin, Inhibits Nuclear Factor-κB Activation
    Arieh Moussaieff, Esther Shohami, Yoel Kashman, Ester Fride, M. Lienhard Schmitz, Florian Renner, Bernd L. Fiebich, Eduardo Munoz, Yinon Ben-Neriah and Raphael Mechoulam
    Molecular Pharmacology December 2007, 72 (6) 1657-1664; DOI: https://doi.org/10.1124/mol.107.038810
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In this issue

Molecular Pharmacology: 72 (6)
Molecular Pharmacology
Vol. 72, Issue 6
1 Dec 2007
  • Table of Contents
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  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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