Table of Contents

Articles

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  Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II

  Annie Quan, Andrew B. McGeachie, Damien J. Keating, Ellen M. van Dam, Jenny Rusak, Ngoc Chau, Chandra S. Malladi, Chen Chen, Adam McCluskey, Michael A. Cousin and Phillip J. Robinson

  Molecular Pharmacology December 2007, 72 (6) 1425-1439; DOI: https://doi.org/10.1124/mol.107.034207
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  Monitoring Interactions between Receptor Tyrosine Kinases and Their Downstream Effector Proteins in Living Cells Using Bioluminescence Resonance Energy Transfer

  Philip K. Tan, Jean Wang, Pey-Lih H. Littler, Kenneth K. Wong, Timothy A. Sweetnam, William Keefe, Norman R. Nash, Esther C. Reding, Fabrice Piu, Mark R. Brann and Hans H. Schiffer

  Molecular Pharmacology December 2007, 72 (6) 1440-1446; DOI: https://doi.org/10.1124/mol.107.039636
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  Evidence for Functional P2X₄/P2X₇ Heteromeric Receptors

  Chang Guo, Marianela Masin, Omar S. Qureshi and Ruth D. Murrell-Lagnado

  Molecular Pharmacology December 2007, 72 (6) 1447-1456; DOI: https://doi.org/10.1124/mol.107.035980
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  A Dioxin-Responsive Enhancer 3′ of the Human CYP1A2 Gene

  Steven T. Okino, Linda C. Quattrochi, Deepa Pookot, Mieko Iwahashi and Rajvir Dahiya

  Molecular Pharmacology December 2007, 72 (6) 1457-1465; DOI: https://doi.org/10.1124/mol.107.039826
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  Mitochondria, Calcium, and Calpain are Key Mediators of Resveratrol-Induced Apoptosis in Breast Cancer

  Dhruv Sareen, Soesiawati R. Darjatmoko, Daniel M. Albert and Arthur S. Polans

  Molecular Pharmacology December 2007, 72 (6) 1466-1475; DOI: https://doi.org/10.1124/mol.107.039040
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  Transforming Growth Factor-β1 Impairs Endothelin-1-Mediated Contraction of Brain Vessels by Inducing Mitogen-Activated Protein (MAP) Kinase Phosphatase-1 and Inhibiting p38 MAP Kinase

  Xin-Kang Tong and Edith Hamel

  Molecular Pharmacology December 2007, 72 (6) 1476-1483; DOI: https://doi.org/10.1124/mol.107.039602
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  Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands

  J. Alex Goodwin, Edward C. Hulme, Christopher J. Langmead and Ben G. Tehan

  Molecular Pharmacology December 2007, 72 (6) 1484-1496; DOI: https://doi.org/10.1124/mol.107.038265
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  Identification of a Postendocytic Sorting Sequence in CCR5

  Maurine Delhaye, Audrey Gravot, Diana Ayinde, Florence Niedergang, Marc Alizon and Anne Brelot

  Molecular Pharmacology December 2007, 72 (6) 1497-1507; DOI: https://doi.org/10.1124/mol.107.038422
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  Resveratrol (trans-3,5,4′-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving Activation of Aryl Hydrocarbon Receptor and Estrogen Receptor

  Narendra P. Singh, Venkatesh L. Hegde, Lorne J. Hofseth, Mitzi Nagarkatti and Prakash Nagarkatti

  Molecular Pharmacology December 2007, 72 (6) 1508-1521; DOI: https://doi.org/10.1124/mol.107.038984
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  The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels

  Jodene Eldstrom, Zhuren Wang, Hongjian Xu, Marc Pourrier, Alan Ezrin, Ken Gibson and David Fedida

  Molecular Pharmacology December 2007, 72 (6) 1522-1534; DOI: https://doi.org/10.1124/mol.107.039388
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  The N-Terminal Domains of both NR1 and NR2 Subunits Determine Allosteric Zn²⁺ Inhibition and Glycine Affinity of N-Methyl-d-aspartate Receptors

  Christian Madry, Ivana Mesic, Heinrich Betz and Bodo Laube

  Molecular Pharmacology December 2007, 72 (6) 1535-1544; DOI: https://doi.org/10.1124/mol.107.040071
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  Docosahexaenoic Acid Induces Increases in [Ca²⁺]_i via Inositol 1,4,5-Triphosphate Production and Activates Protein Kinase Cγ and -δ via Phosphatidylserine Binding Site: Implication in Apoptosis in U937 Cells

  Virginie Aires, Aziz Hichami, Rodolphe Filomenko, Aude Plé, Cédric Rébé, Ali Bettaieb and Naim Akhtar Khan

  Molecular Pharmacology December 2007, 72 (6) 1545-1556; DOI: https://doi.org/10.1124/mol.107.039792
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  CB₁ Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a

  Jason L. Niehaus, Yunguang Liu, Kathleen T. Wallis, Michaela Egertová, Sheela G. Bhartur, Somnath Mukhopadhyay, Shanping Shi, Hengjun He, Dana E. Selley, Allyn C. Howlett, Maurice R. Elphick and Deborah L. Lewis

  Molecular Pharmacology December 2007, 72 (6) 1557-1566; DOI: https://doi.org/10.1124/mol.107.039263
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  Identification of the Substrate Binding Region of Vesicular Monoamine Transporter-2 (VMAT-2) Using Iodoaminoflisopolol as a Novel Photoprobe

  Anupama Gopalakrishnan, Michael Sievert and Arnold E. Ruoho

  Molecular Pharmacology December 2007, 72 (6) 1567-1575; DOI: https://doi.org/10.1124/mol.107.034439
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  Inhibition of TRPP3 Channel by Amiloride and Analogs

  Xiao-Qing Dai, Alkarim Ramji, Yan Liu, Qiang Li, Edward Karpinski and Xing-Zhen Chen

  Molecular Pharmacology December 2007, 72 (6) 1576-1585; DOI: https://doi.org/10.1124/mol.107.037150
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  Aspirin Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-Regulation

  Jinsang Yoo and Yong J. Lee

  Molecular Pharmacology December 2007, 72 (6) 1586-1592; DOI: https://doi.org/10.1124/mol.107.039610
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  Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase

  Nicola Solaroli, Xinyu Zheng, Magnus Johansson, Jan Balzarini and Anna Karlsson

  Molecular Pharmacology December 2007, 72 (6) 1593-1598; DOI: https://doi.org/10.1124/mol.107.037051
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  Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of β-Catenin

  Gyu-Yong Song, Jee-Hyun Lee, Munju Cho, Byeoung-Soo Park, Dong-Eun Kim and Sangtaek Oh

  Molecular Pharmacology December 2007, 72 (6) 1599-1606; DOI: https://doi.org/10.1124/mol.107.040253
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  K252a Prevents Nigral Dopaminergic Cell Death Induced by 6-Hydroxydopamine through Inhibition of Both Mixed-Lineage Kinase 3/c-Jun NH₂-Terminal Kinase 3 (JNK3) and Apoptosis-Inducing Kinase 1/JNK3 Signaling Pathways

  Jing Pan, Gang Wang, Hong-Qi Yang, Zhen Hong, Qin Xiao, Ru-Jing Ren, Hai-Yan Zhou, Li Bai and Sheng-Di Chen

  Molecular Pharmacology December 2007, 72 (6) 1607-1618; DOI: https://doi.org/10.1124/mol.107.038463
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  Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation

  Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Insook Kim, Kunio Shiota, Frank J. Gonzalez and Yuichi Sugiyama

  Molecular Pharmacology December 2007, 72 (6) 1619-1625; DOI: https://doi.org/10.1124/mol.107.039701
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  Adenosine A_2A Receptor Occupancy Stimulates Collagen Expression by Hepatic Stellate Cells via Pathways Involving Protein Kinase A, Src, and Extracellular Signal-Regulated Kinases 1/2 Signaling Cascade or p38 Mitogen-Activated Protein Kinase Signaling Pathway

  Jiantu Che, Edwin S. L. Chan and Bruce N. Cronstein

  Molecular Pharmacology December 2007, 72 (6) 1626-1636; DOI: https://doi.org/10.1124/mol.107.038760
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  Cystine-Glutamate Transporter SLC7A11 Mediates Resistance to Geldanamycin but Not to 17-(Allylamino)-17-demethoxygeldanamycin

  Ruqing Liu, Paul E. Blower, Anh-Nhan Pham, Jialong Fang, Zunyan Dai, Carolyn Wise, Bridgette Green, Candee H. Teitel, Baitang Ning, Wenhua Ling, Beverly D. Lyn-Cook, Fred F. Kadlubar, Wolfgang Sadée and Ying Huang

  Molecular Pharmacology December 2007, 72 (6) 1637-1646; DOI: https://doi.org/10.1124/mol.107.039644
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  Repression of T-Cell Function by Thionamides Is Mediated by Inhibition of the Activator Protein-1/Nuclear Factor of Activated T-Cells Pathway and Is Associated with a Common Structure

  Matjaz Humar, Hannah Dohrmann, Philipp Stein, Nikolaos Andriopoulos, Ulrich Goebel, Bernd Heimrich, Martin Roesslein, Rene Schmidt, Christian I. Schwer, Alexander Hoetzel, Torsten Loop, Heike L. Pahl, Klaus K. Geiger and Benedikt H. J. Pannen

  Molecular Pharmacology December 2007, 72 (6) 1647-1656; DOI: https://doi.org/10.1124/mol.107.038141
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  Incensole Acetate, a Novel Anti-Inflammatory Compound Isolated from Boswellia Resin, Inhibits Nuclear Factor-κB Activation

  Arieh Moussaieff, Esther Shohami, Yoel Kashman, Ester Fride, M. Lienhard Schmitz, Florian Renner, Bernd L. Fiebich, Eduardo Munoz, Yinon Ben-Neriah and Raphael Mechoulam

  Molecular Pharmacology December 2007, 72 (6) 1657-1664; DOI: https://doi.org/10.1124/mol.107.038810