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Molecular Pharmacology

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OtherMINIREVIEW

Functional Selectivity through Protean and Biased Agonism: Who Steers the Ship?

Terry Kenakin
Molecular Pharmacology December 2007, 72 (6) 1393-1401; DOI: https://doi.org/10.1124/mol.107.040352
Terry Kenakin
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Article Information

vol. 72 no. 6 1393-1401
DOI 
https://doi.org/10.1124/mol.107.040352
PubMed 
17901198

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 29, 2007
  • Accepted September 27, 2007
  • Published online November 16, 2007.

Article Versions

  • Earlier version (September 27, 2007 - 08:41).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Terry Kenakin
  1. Department of Biological Reagents and Assay Development, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina
  1. Address correspondence to:
    Terry Kenakin, Department of Biological Reagents and Assay Development, GlaxoSmithKline Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709. E-mail: terry.p.kenakin{at}gsk.com
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Molecular Pharmacology: 72 (6)
Molecular Pharmacology
Vol. 72, Issue 6
1 Dec 2007
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OtherMINIREVIEW

Functional Selectivity through Protean and Biased Agonism: Who Steers the Ship?

Terry Kenakin
Molecular Pharmacology December 1, 2007, 72 (6) 1393-1401; DOI: https://doi.org/10.1124/mol.107.040352

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OtherMINIREVIEW

Functional Selectivity through Protean and Biased Agonism: Who Steers the Ship?

Terry Kenakin
Molecular Pharmacology December 1, 2007, 72 (6) 1393-1401; DOI: https://doi.org/10.1124/mol.107.040352
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Jump to section

  • Article
    • Abstract
    • Single Receptor State Receptor Selectivity
    • Receptor-Based Biased Functional Selectivity
    • Protean Agonism
    • Indirect Ligand-Induced Bias
    • Receptor-Based Selectivity
    • Should Functional Selectivity Be an Expected Event?
    • Conclusions
    • Appendix
    • Footnotes
    • References
  • Figures & Data
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