Advertisement
Research ArticleArticle

The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels

Jodene Eldstrom, Zhuren Wang, Hongjian Xu, Marc Pourrier, Alan Ezrin, Ken Gibson and David Fedida
Molecular Pharmacology December 2007, 72 (6) 1522-1534; DOI: https://doi.org/10.1124/mol.107.039388

Article Information

vol. 72 no. 6 1522-1534
DOI 
https://doi.org/10.1124/mol.107.039388
PubMed 
17872968
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 3, 2007
  • Accepted September 14, 2007
  • Published online November 16, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jodene Eldstrom,
  2. Zhuren Wang,
  3. Hongjian Xu,
  4. Marc Pourrier,
  5. Alan Ezrin,
  6. Ken Gibson and
  7. David Fedida
  1. Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada (J.E., Z.W., H.X., D.F.); and Cardiome Pharma Corp., Vancouver, British Columbia, Canada (M.P., A.E., K.G.)
  1. Address correspondence to:
    Dr. David Fedida, Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver BC, Canada V6T 1Z3. E-mail: fedida{at}interchange.ubc.ca
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: September 2007 to May 2023

AbstractFullPdf
Sep 200720083
Oct 2007150101
Nov 2007482375
Dec 2007314144
Jan 2008494556
Feb 2008262949
Mar 2008312942
Apr 2008192327
May 2008282025
Jun 2008411629
Jul 2008291714
Aug 200823713
Sep 20083189
Oct 2008301521
Nov 200817610
Dec 2008132222
Jan 2009151415
Feb 200981422
Mar 2009223542
Apr 200992740
May 200981726
Jun 200951316
Jul 200992024
Aug 2009132553
Sep 200951711
Oct 200921915
Nov 20091258
Dec 20095119
Jan 2010111722
Feb 2010121016
Mar 201062220
Apr 20106146
May 20105239
Jun 201021820
Jul 2010252621
Aug 201072014
Sep 2010243917
Oct 2010113025
Nov 2010142724
Dec 2010221517
Jan 2011132836
Feb 2011141717
Mar 2011144423
Apr 201182115
May 2011103214
Jun 201183318
Jul 2011241921
Aug 2011212113
Sep 2011213418
Oct 2011355124
Nov 2011296925
Dec 2011173020
Jan 2012112417
Feb 2012253927
Mar 2012384421
Apr 2012231913
May 2012283218
Jun 2012161919
Jul 2012251813
Aug 2012112420
Sep 2012192719
Oct 2012342026
Nov 2012172214
Dec 201236118
Jan 201326268
Feb 2013291130
Mar 2013221413
Apr 2013201111
May 201319139
Jun 201310143
Jul 20131764
Aug 20139169
Sep 201315159
Oct 201323259
Nov 2013163013
Dec 2013133327
Jan 201481511
Feb 201471612
Mar 2014122535
Apr 20142811310
May 201415268
Jun 20146115
Jul 2014122417
Aug 201412469
Sep 2014198222
Oct 201412367
Nov 2014125013
Dec 2014142810
Jan 20153168
Feb 20153288
Mar 2015201911
Apr 201515135
May 201512235
Jun 201521103
Jul 2015171218
Aug 20159107
Sep 2015102010
Oct 20157176
Nov 2015663
Dec 2015281
Jan 201617517
Feb 2016171110
Mar 2016111110
Apr 2016898
May 2016101210
Jun 20166912
Jul 2016122317
Aug 201691411
Sep 201641015
Oct 201621411
Nov 20160739
Dec 20160229
Jan 201701812
Feb 20171246
Mar 20171121
Apr 2017194
May 20170142
Jun 20170115
Jul 20172124
Aug 20171114
Sep 20171913
Oct 20171179
Nov 201722117
Dec 20170156
Jan 201823021
Feb 20181126
Mar 20180197
Apr 201822217
May 20180179
Jun 20181115
Jul 20180128
Aug 20180145
Sep 20181107
Oct 201811920
Nov 201802018
Dec 20183303
Jan 20192122
Feb 2019824
Mar 20191405
Apr 20192234
May 2019905
Jun 201915711
Jul 20191305
Aug 201933100
Sep 201919560
Oct 20191003
Nov 20191941
Dec 20192925
Jan 2020910
Feb 2020820
Mar 2020400
Apr 20201303
May 20201101
Jun 20201201
Jul 2020911
Aug 2020924
Sep 2020601
Oct 2020802
Nov 20203585
Dec 20201804
Jan 2021466
Feb 20211058
Mar 20212177
Apr 20215913
May 20216255
Jun 2021641
Jul 20212414
Aug 20211021
Sep 2021720
Oct 2021400
Nov 20211535
Dec 2021976
Jan 20222410
Feb 20221721
Mar 20222812
Apr 20223711
May 2022710
Jun 20222022
Jul 20221223
Aug 2022823
Sep 20229632
Oct 202219397
Nov 202239121
Dec 20222212
Jan 20233131
Feb 20231312
Mar 20232142
Apr 2023614
May 2023623

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels

Jodene Eldstrom, Zhuren Wang, Hongjian Xu, Marc Pourrier, Alan Ezrin, Ken Gibson and David Fedida
Molecular Pharmacology December 1, 2007, 72 (6) 1522-1534; DOI: https://doi.org/10.1124/mol.107.039388
Reddit logo Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement