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Research ArticleArticle

Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Remko A. Bakker, Aldo Jongejan, Kamonchanok Sansuk, Uli Hacksell, Henk Timmerman, Mark R. Brann, Dave M. Weiner, Leonardo Pardo and Rob Leurs
Molecular Pharmacology January 2008, 73 (1) 94-103; DOI: https://doi.org/10.1124/mol.107.038547

Article Information

vol. 73 no. 1 94-103
DOI 
https://doi.org/10.1124/mol.107.038547
PubMed 
17959710
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 28, 2007
  • Accepted October 16, 2007
  • Published online December 19, 2007.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Remko A. Bakker1,
  2. Aldo Jongejan,
  3. Kamonchanok Sansuk,
  4. Uli Hacksell,
  5. Henk Timmerman,
  6. Mark R. Brann,
  7. Dave M. Weiner2,
  8. Leonardo Pardo and
  9. Rob Leurs
  1. Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (R.A.B., A.J., K.S., H.T., and R.L.); ACADIA Pharmaceuticals Inc., San Diego, California (R.A.B., U.H., M.R.B., and D.M.W.); Department of Pharmacology, University of California at San Diego, San Diego, California (M.R.B.); Department of Neurosciences, University of California at San Diego, San Diego, California (D.M.W.); Department of Psychiatry, University of California at San Diego, San Diego, California (D.M.W.); and Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain (L.P.)
  1. Address correspondence to:
    Dr. R. Leurs, Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. E-mail: r.leurs{at}few.vu.nl
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Research ArticleArticle

Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Remko A. Bakker, Aldo Jongejan, Kamonchanok Sansuk, Uli Hacksell, Henk Timmerman, Mark R. Brann, Dave M. Weiner, Leonardo Pardo and Rob Leurs
Molecular Pharmacology January 1, 2008, 73 (1) 94-103; DOI: https://doi.org/10.1124/mol.107.038547
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