Table of Contents

Articles

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  Cortical Glutamatergic Neurons Mediate the Motor Sedative Action of Diazepam

  A. Zeller, F. Crestani, I. Camenisch, T. Iwasato, S. Itohara, J. M. Fritschy and U. Rudolph

  Molecular Pharmacology February 2008, 73 (2) 282-291; DOI: https://doi.org/10.1124/mol.107.038828
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  Distinct Phosphorylation Sites in the SST2A Somatostatin Receptor Control Internalization, Desensitization, and Arrestin Binding

  Q. Liu, D. A. Dewi, W. Liu, M. S. Bee and A. Schonbrunn

  Molecular Pharmacology February 2008, 73 (2) 292-304; DOI: https://doi.org/10.1124/mol.107.038570
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  Conformational Flexibility of Helix VI Is Essential for Substrate Permeation of the Human Apical Sodium-Dependent Bile Acid Transporter

  Naissan Hussainzada, Akash Khandewal and Peter W. Swaan

  Molecular Pharmacology February 2008, 73 (2) 305-313; DOI: https://doi.org/10.1124/mol.107.041640
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  Anandamide Inhibition of 5-HT_3A Receptors Varies with Receptor Density and Desensitization

  Wei Xiong, Masako Hosoi, Bon-Nyeo Koo and Li Zhang

  Molecular Pharmacology February 2008, 73 (2) 314-322; DOI: https://doi.org/10.1124/mol.107.039149
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  Peroxisome Proliferator-Activated Receptor-α Contributes to the Anti-Inflammatory Activity of Glucocorticoids

  Salvatore Cuzzocrea, Stefano Bruscoli, Emanuela Mazzon, Concetta Crisafulli, Valerio Donato, Rosanna Di Paola, Enrico Velardi, Emanuela Esposito, Giuseppe Nocentini and Carlo Riccardi

  Molecular Pharmacology February 2008, 73 (2) 323-337; DOI: https://doi.org/10.1124/mol.107.041475
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  Cellular and in Vivo Activity of JNJ-28871063, A Nonquinazoline Pan-ErbB Kinase Inhibitor That Crosses the Blood-Brain Barrier and Displays Efficacy against Intracranial Tumors

  Stuart L. Emanuel, Terry V. Hughes, Mary Adams, Catherine A. Rugg, Angel Fuentes-Pesquera, Peter J. Connolly, Niranjan Pandey, Sandra Moreno-Mazza, Jeannene Butler, Virna Borowski, Steven A. Middleton, Robert H. Gruninger, Jennifer R. Story, Cheryl Napier, Beth Hollister and Lee M. Greenberger

  Molecular Pharmacology February 2008, 73 (2) 338-348; DOI: https://doi.org/10.1124/mol.107.041236
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  Characterization of G-Protein Coupled Receptor Kinase Interaction with the Neurokinin-1 Receptor Using Bioluminescence Resonance Energy Transfer

  Rasmus Jorgensen, Nicholas D. Holliday, Jakob L. Hansen, Milka Vrecl, Anders Heding, Thue W. Schwartz and Christian E. Elling

  Molecular Pharmacology February 2008, 73 (2) 349-358; DOI: https://doi.org/10.1124/mol.107.038877
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  A Novel Actin-Binding Domain on Slo1 Calcium-Activated Potassium Channels Is Necessary for Their Expression in the Plasma Membrane

  Shengwei Zou, Smita Jha, Eun Young Kim and Stuart E. Dryer

  Molecular Pharmacology February 2008, 73 (2) 359-368; DOI: https://doi.org/10.1124/mol.107.039743
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  The β1 Subunit of L-Type Voltage-Gated Ca²⁺ Channels Independently Binds to and Inhibits the Gating of Large-Conductance Ca²⁺-Activated K⁺ Channels

  Shengwei Zou, Smita Jha, Eun Young Kim and Stuart E. Dryer

  Molecular Pharmacology February 2008, 73 (2) 369-378; DOI: https://doi.org/10.1124/mol.107.040733
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  Functional Characterization of a Nucleoside-Derived Drug Transporter Variant (hCNT3_C602R) Showing Altered Sodium-Binding Capacity

  Ekaitz Errasti-Murugarren, Pedro Cano-Soldado, Marçal Pastor-Anglada and Fco Javier Casado

  Molecular Pharmacology February 2008, 73 (2) 379-386; DOI: https://doi.org/10.1124/mol.107.041848
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  Repression of Aryl Hydrocarbon Receptor (AHR) Signaling by AHR Repressor: Role of DNA Binding and Competition for AHR Nuclear Translocator

  Brad R. Evans, Sibel I. Karchner, Lenka L. Allan, Richard S. Pollenz, Robert L. Tanguay, Matthew J. Jenny, David H. Sherr and Mark E. Hahn

  Molecular Pharmacology February 2008, 73 (2) 387-398; DOI: https://doi.org/10.1124/mol.107.040204
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  Curcumin Protects the Rat Liver from CCl₄-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation

  Yumei Fu, Shizhong Zheng, Jianguo Lin, Jan Ryerse and Anping Chen

  Molecular Pharmacology February 2008, 73 (2) 399-409; DOI: https://doi.org/10.1124/mol.107.039818
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  Small Molecule Disruption of G Protein βγ Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation

  D. M. Lehmann, A. M. P. B. Seneviratne and A. V. Smrcka

  Molecular Pharmacology February 2008, 73 (2) 410-418; DOI: https://doi.org/10.1124/mol.107.041780
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  BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines

  Lisa M. Greene, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer

  Molecular Pharmacology February 2008, 73 (2) 419-430; DOI: https://doi.org/10.1124/mol.107.039024
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  Role of Extracellular Domain Dimerization in Agonist-Induced Activation of Natriuretic Peptide Receptor A

  Marie Parat, Normand McNicoll, Brian Wilkes, Alain Fournier and André De Léan

  Molecular Pharmacology February 2008, 73 (2) 431-440; DOI: https://doi.org/10.1124/mol.107.039982
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  Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB₁ and CB₂

  Douglas McHugh, Carolyn Tanner, Raphael Mechoulam, Roger G. Pertwee and Ruth A. Ross

  Molecular Pharmacology February 2008, 73 (2) 441-450; DOI: https://doi.org/10.1124/mol.107.041863
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  Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4α to the Proximal Promoter

  Tania Onica, Kathleen Nichols, Meghan Larin, Lorraine Ng, Ann Maslen, Zdenek Dvorak, Jean-Marc Pascussi, Marie-Josée Vilarem, Patrick Maurel and Gordon M. Kirby

  Molecular Pharmacology February 2008, 73 (2) 451-460; DOI: https://doi.org/10.1124/mol.107.039354
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  Transport of Cisplatin by the Copper Efflux Transporter ATP7B

  Roohangiz Safaei, Shinji Otani, Barrett J. Larson, Michael L. Rasmussen and Stephen B. Howell

  Molecular Pharmacology February 2008, 73 (2) 461-468; DOI: https://doi.org/10.1124/mol.107.040980
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  Cloning and Functional Expression of a Novel G_i Protein-Coupled Receptor for Adenine from Mouse Brain

  Ivar von Kügelgen, Anke C. Schiedel, Kristina Hoffmann, Bernt B. A. Alsdorf, Aliaa Abdelrahman and Christa E. Müller

  Molecular Pharmacology February 2008, 73 (2) 469-477; DOI: https://doi.org/10.1124/mol.107.037069
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  Structural Analog of Sildenafil Identified as a Novel Corrector of the F508del-CFTR Trafficking Defect

  Renaud Robert, Graeme W. Carlile, Catalin Pavel, Na Liu, Suzana M. Anjos, Jie Liao, Yishan Luo, Donglei Zhang, David Y. Thomas and John W. Hanrahan

  Molecular Pharmacology February 2008, 73 (2) 478-489; DOI: https://doi.org/10.1124/mol.107.040725
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  Reduced Expression of DNA Topoisomerase I in SF295 Human Glioblastoma Cells Selected for Resistance to Homocamptothecin and Diflomotecan

  Zhiyong Liao, Robert W. Robey, Josée Guirouilh-Barbat, Kenneth K. W. To, Orsolya Polgar, Susan E. Bates and Yves Pommier

  Molecular Pharmacology February 2008, 73 (2) 490-497; DOI: https://doi.org/10.1124/mol.107.041178
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  Impact of Targeting the Adenine- and Uracil-Rich Element of bcl-2 mRNA with Oligoribonucleotides on Apoptosis, Cell Cycle, and Neuronal Differentiation in SHSY-5Y Cells

  Laura Papucci, Ewa Witort, Anna Maria Bevilacqua, Martino Donnini, Matteo Lulli, Elisabetta Borchi, Khalid S. A. Khabar, Alessio Tempestini, Andrea Lapucci, Nicola Schiavone, Angelo Nicolin and Sergio Capaccioli

  Molecular Pharmacology February 2008, 73 (2) 498-508; DOI: https://doi.org/10.1124/mol.107.038323
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  A Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription

  Ralph Krätzner, Florian Fröhlich, Katrin Lepler, Michaela Schröder, Katharina Röher, Corinna Dickel, Mladen V. Tzvetkov, Thomas Quentin, Elke Oetjen and Willhart Knepel

  Molecular Pharmacology February 2008, 73 (2) 509-517; DOI: https://doi.org/10.1124/mol.107.035568
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  [³H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor

  Laura H. Heitman, Julia Oosterom, Kimberly M. Bonger, Cornelis M. Timmers, Peter H. G. Wiegerinck and Adriaan P. IJzerman

  Molecular Pharmacology February 2008, 73 (2) 518-524; DOI: https://doi.org/10.1124/mol.107.039875
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  Multiple Binding Sites for Substrates and Modulators of Semicarbazide-Sensitive Amine Oxidases: Kinetic Consequences

  Andrew Holt, David J. Smith, Laura Cendron, Giuseppe Zanotti, Adelio Rigo and Maria Luisa Di Paolo

  Molecular Pharmacology February 2008, 73 (2) 525-538; DOI: https://doi.org/10.1124/mol.107.040964
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  Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells

  Paul D. Upton, Lu Long, Richard C. Trembath and Nicholas W. Morrell

  Molecular Pharmacology February 2008, 73 (2) 539-552; DOI: https://doi.org/10.1124/mol.107.041673
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  Methyl 2-Cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate Is a Peroxisome Proliferator-Activated Receptor-γ Agonist That Induces Receptor-Independent Apoptosis in LNCaP Prostate Cancer Cells

  Sabitha Papineni, Sudhakar Chintharlapalli and Stephen Safe

  Molecular Pharmacology February 2008, 73 (2) 553-565; DOI: https://doi.org/10.1124/mol.107.041285
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  Mitogenic Effects of Cytokines on Smooth Muscle Are Critically Dependent on Protein Kinase A and Are Unmasked by Steroids and Cyclooxygenase Inhibitors

  Anna M. Misior, Huandong Yan, Rodolfo M. Pascual, Deepak A. Deshpande, Reynold A. Panettieri and Raymond B. Penn

  Molecular Pharmacology February 2008, 73 (2) 566-574; DOI: https://doi.org/10.1124/mol.107.040519
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  3-Methylcholanthrene Displays Dual Effects on Estrogen Receptor (ER) α and ERβ Signaling in a Cell-Type Specific Fashion

  Elin Swedenborg, Joëlle Rüegg, Anne Hillenweck, Stefan Rehnmark, Malin Hedengran Faulds, Daniel Zalko, Ingemar Pongratz and Katarina Pettersson

  Molecular Pharmacology February 2008, 73 (2) 575-586; DOI: https://doi.org/10.1124/mol.107.036384
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  Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis?

  Chenqi Zhao, Maria J. Fernandes, Glenn D. Prestwich, Mélanie Turgeon, John Di Battista, Timothy Clair, Patrice E. Poubelle and Sylvain G. Bourgoin

  Molecular Pharmacology February 2008, 73 (2) 587-600; DOI: https://doi.org/10.1124/mol.107.038216
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  Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision

  Jessica Radzio and Nicolas Sluis-Cremer

  Molecular Pharmacology February 2008, 73 (2) 601-606; DOI: https://doi.org/10.1124/mol.107.038596
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  Regulation of Human 3α-Hydroxysteroid Dehydrogenase (AKR1C4) Expression by the Liver X Receptor α

  Keith R. Stayrook, Pamela M. Rogers, Rajesh S. Savkur, Yongjun Wang, Chen Su, Gabor Varga, Xin Bu, Tao Wei, Sunil Nagpal, Xiaole Shirley Liu and Thomas P. Burris

  Molecular Pharmacology February 2008, 73 (2) 607-612; DOI: https://doi.org/10.1124/mol.107.039099