Table of Contents

Articles

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  Ginsenoside Rg₃ Inhibits Human Kv1.4 Channel Currents by Interacting with the Lys531 Residue

  Jun-Ho Lee, Byung-Hwan Lee, Sun-Hye Choi, In-Soo Yoon, Mi Kyung Pyo, Tae-Joon Shin, Woo-Sung Choi, Yoongho Lim, Hyewhon Rhim, Kwang Hee Won, Yong Whan Lim, Han Choe, Dong-Hyun Kim, Yang In Kim and Seung-Yeol Nah

  Molecular Pharmacology March 2008, 73 (3) 619-626; DOI: https://doi.org/10.1124/mol.107.040360
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  Antitumor Mechanisms of Systemically Administered Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck

  Sufi Mary Thomas, Michelene Jeter Ogagan, Maria L. Freilino, Sandy Strychor, Dustin R. Walsh, William E. Gooding, Jennifer Rubin Grandis and William C. Zamboni

  Molecular Pharmacology March 2008, 73 (3) 627-638; DOI: https://doi.org/10.1124/mol.107.041160
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  2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic Acid (PD-307243) Causes Instantaneous Current through Human Ether-a-go-go-Related Gene Potassium Channels

  Earl Gordon, Irina M. Lozinskaya, Zuojun Lin, Simon F. Semus, Frank E. Blaney, Robert N. Willette and Xiaoping Xu

  Molecular Pharmacology March 2008, 73 (3) 639-651; DOI: https://doi.org/10.1124/mol.107.041152
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  Activation of the Dual-Leucine-Zipper-Bearing Kinase and Induction of β-Cell Apoptosis by the Immunosuppressive Drug Cyclosporin A

  Silke Plaumann, Roland Blume, Svenja Börchers, Hans Jürgen Steinfelder, Willhart Knepel and Elke Oetjen

  Molecular Pharmacology March 2008, 73 (3) 652-659; DOI: https://doi.org/10.1124/mol.107.040782
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  Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of Human Dehydroepiandrosterone Sulfotransferase (SULT2A1)

  Lu-Yi Lu, Yin-Cheng Hsieh, Ming-Yih Liu, Yih-Hung Lin, Chun-Jung Chen and Yuh-Shyong Yang

  Molecular Pharmacology March 2008, 73 (3) 660-668; DOI: https://doi.org/10.1124/mol.107.041038
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  Potent Inhibition of Human Apurinic/Apyrimidinic Endonuclease 1 by Arylstibonic Acids

  Lauren A. Seiple, John H. Cardellina, Rhone Akee and James T. Stivers

  Molecular Pharmacology March 2008, 73 (3) 669-677; DOI: https://doi.org/10.1124/mol.107.042622
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  Caveolin Regulates Kv1.5 Trafficking to Cholesterol-Rich Membrane Microdomains

  Dyke P. McEwen, Qiuju Li, Sajida Jackson, Paul M. Jenkins and Jeffrey R. Martens

  Molecular Pharmacology March 2008, 73 (3) 678-685; DOI: https://doi.org/10.1124/mol.107.042093
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  A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase IIα Inhibitors

  Hong Liang, Xing Wu, Jack C. Yalowich and Brian B. Hasinoff

  Molecular Pharmacology March 2008, 73 (3) 686-696; DOI: https://doi.org/10.1124/mol.107.041624
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  Derlin-1 and p97/Valosin-Containing Protein Mediate the Endoplasmic Reticulum-Associated Degradation of Human V2 Vasopressin Receptors

  Isabel Schwieger, Katja Lautz, Eberhard Krause, Walter Rosenthal, Burkhard Wiesner and Ricardo Hermosilla

  Molecular Pharmacology March 2008, 73 (3) 697-708; DOI: https://doi.org/10.1124/mol.107.040931
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  Antitumorigenic Effects of Peroxisome Proliferator-Activated Receptor-γ in Non-Small-Cell Lung Cancer Cells Are Mediated by Suppression of Cyclooxygenase-2 via Inhibition of Nuclear Factor-κB

  Yvette Bren-Mattison, Amy M. Meyer, Vicki Van Putten, Howard Li, Katherine Kuhn, Robert Stearman, Mary Weiser-Evans, Robert A. Winn, Lynn E. Heasley and Raphael A. Nemenoff

  Molecular Pharmacology March 2008, 73 (3) 709-717; DOI: https://doi.org/10.1124/mol.107.042002
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  Cell-Based and Biochemical Structure-Activity Analyses of Analogs of the Microtubule Stabilizer Dictyostatin

  Brianne S. Raccor, Andreas Vogt, Rachel P. Sikorski, Charitha Madiraju, Raghavan Balachandran, Kia Montgomery, Youseung Shin, Yoshikazu Fukui, Won-Hyuk Jung, Dennis P. Curran and Billy W. Day

  Molecular Pharmacology March 2008, 73 (3) 718-726; DOI: https://doi.org/10.1124/mol.107.042598
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  The Two Isoforms of the Na⁺/Ca²⁺ Exchanger, NCX1 and NCX3, Constitute Novel Additional Targets for the Prosurvival Action of Akt/Protein Kinase B Pathway

  Luigi Formisano, Mariangela Saggese, Agnese Secondo, Rossana Sirabella, Pasquale Vito, Valeria Valsecchi, Pasquale Molinaro, Gianfranco Di Renzo and Lucio Annunziato

  Molecular Pharmacology March 2008, 73 (3) 727-737; DOI: https://doi.org/10.1124/mol.107.042549
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  Inhibition of Inducible Nitric-Oxide Synthase Protects Human T Cells from Hypoxia-Induced Apoptosis

  Juliann G. Kiang, Sandeep Krishnan, Xinyue Lu and Yansong Li

  Molecular Pharmacology March 2008, 73 (3) 738-747; DOI: https://doi.org/10.1124/mol.107.041079
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  Inverse Agonist and Neutral Antagonist Actions of Antidepressants at Recombinant and Native 5-Hydroxytryptamine_2C Receptors: Differential Modulation of Cell Surface Expression and Signal Transduction

  Benjamin Chanrion, Clotilde Mannoury la Cour, Sophie Gavarini, Mathieu Seimandi, Laurent Vincent, Jean-François Pujol, Joël Bockaert, Philippe Marin and Mark J. Millan

  Molecular Pharmacology March 2008, 73 (3) 748-757; DOI: https://doi.org/10.1124/mol.107.041574
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  Small-Molecule Screen Identifies Inhibitors of a Human Intestinal Calcium-Activated Chloride Channel

  Ricardo De La Fuente, Wan Namkung, Aaron Mills and A. S. Verkman

  Molecular Pharmacology March 2008, 73 (3) 758-768; DOI: https://doi.org/10.1124/mol.107.043208
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  Dioxin-Mediated Up-Regulation of Aryl Hydrocarbon Receptor Target Genes Is Dependent on the Calcium/Calmodulin/CaMKIα Pathway

  Patricia Monteiro, David Gilot, Eric Le Ferrec, Claudine Rauch, Dominique Lagadic-Gossmann and Olivier Fardel

  Molecular Pharmacology March 2008, 73 (3) 769-777; DOI: https://doi.org/10.1124/mol.107.043125
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  Interferon β Augments Tuberous Sclerosis Complex 2 (TSC2)-Dependent Inhibition of TSC2-Null ELT3 and Human Lymphangioleiomyomatosis-Derived Cell Proliferation

  Elena A. Goncharova, Dmitry A. Goncharov, Amelia Chisolm, Matthew S. Spaits, Poay N. Lim, Gregory Cesarone, Irene Khavin, Omar Tliba, Yassine Amrani, Reynold A. Panettieri and Vera P. Krymskaya

  Molecular Pharmacology March 2008, 73 (3) 778-788; DOI: https://doi.org/10.1124/mol.107.040824
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  Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists

  Rama Kondru, Jun Zhang, Changhua Ji, Tara Mirzadegan, David Rotstein, Surya Sankuratri and Marianna Dioszegi

  Molecular Pharmacology March 2008, 73 (3) 789-800; DOI: https://doi.org/10.1124/mol.107.042101
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  Activity and Subcellular Trafficking of the Sodium-Coupled Choline Transporter CHT Is Regulated Acutely by Peroxynitrite

  Metta Pinthong, Stefanie A. G. Black, Fabiola M. Ribeiro, Chumpol Pholpramool, Stephen S. G. Ferguson and R. Jane Rylett

  Molecular Pharmacology March 2008, 73 (3) 801-812; DOI: https://doi.org/10.1124/mol.107.040881
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  Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

  Claus J. Loland, Rajeev I. Desai, Mu-Fa Zou, Jianjing Cao, Peter Grundt, Klaus Gerstbrein, Harald H. Sitte, Amy Hauck Newman, Jonathan L. Katz and Ulrik Gether

  Molecular Pharmacology March 2008, 73 (3) 813-823; DOI: https://doi.org/10.1124/mol.107.039800
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  The Telomeric Protein TRF2 Is Critical for the Protection of A549 Cells from Both Telomere Erosion and DNA Double-Strand Breaks Driven by Salvicine

  Yong-Wei Zhang, Zhi-Xiang Zhang, Ze-Hong Miao and Jian Ding

  Molecular Pharmacology March 2008, 73 (3) 824-832; DOI: https://doi.org/10.1124/mol.107.039081
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  Iron Chelation by Clinically Relevant Anthracyclines: Alteration in Expression of Iron-Regulated Genes and Atypical Changes in Intracellular Iron Distribution and Trafficking

  X. Xu, R. Sutak and D. R. Richardson

  Molecular Pharmacology March 2008, 73 (3) 833-844; DOI: https://doi.org/10.1124/mol.107.041335
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  Progesterone Receptor (PR) Isoforms PRA and PRB Differentially Regulate Expression of the Breast Cancer Resistance Protein in Human Placental Choriocarcinoma BeWo Cells

  Honggang Wang, Eun-Woo Lee, Lin Zhou, Peter C. K. Leung, Douglas D. Ross, Jashvant D. Unadkat and Qingcheng Mao

  Molecular Pharmacology March 2008, 73 (3) 845-854; DOI: https://doi.org/10.1124/mol.107.041087
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  An Intracellular Allosteric Site for a Specific Class of Antagonists of the CC Chemokine G Protein-Coupled Receptors CCR4 and CCR5

  Glen Andrews, Carolyn Jones and Keith A. Wreggett

  Molecular Pharmacology March 2008, 73 (3) 855-867; DOI: https://doi.org/10.1124/mol.107.039321
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  Plasticity of Adenylyl Cyclase-Related Signaling Sequelae after Long-Term Morphine Treatment

  Michael Shy, Sumita Chakrabarti and Alan R. Gintzler

  Molecular Pharmacology March 2008, 73 (3) 868-879; DOI: https://doi.org/10.1124/mol.107.042184
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  Lipid Composition Alters Drug Action at the Nicotinic Acetylcholine Receptor

  John E. Baenziger, Stephen E. Ryan, Michael M. Goodreid, Ngoc Q. Vuong, Raymond M. Sturgeon and Corrie J. B. daCosta

  Molecular Pharmacology March 2008, 73 (3) 880-890; DOI: https://doi.org/10.1124/mol.107.039008
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  Identification of Oxysterol 7α-Hydroxylase (Cyp7b1) as a Novel Retinoid-Related Orphan Receptor α (RORα) (NR1F1) Target Gene and a Functional Cross-Talk between RORα and Liver X Receptor (NR1H3)

  Taira Wada, Hong Soon Kang, Martin Angers, Haibiao Gong, Shikha Bhatia, Shaheen Khadem, Songrong Ren, Ewa Ellis, Stephen C. Strom, Anton M. Jetten and Wen Xie

  Molecular Pharmacology March 2008, 73 (3) 891-899; DOI: https://doi.org/10.1124/mol.107.040741
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  Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes

  Andria L. Del Tredici, Carsten B. Andersen, Erika A. Currier, Steven R. Ohrmund, Luke C. Fairbain, Birgitte W. Lund, Norman Nash, Roger Olsson and Fabrice Piu

  Molecular Pharmacology March 2008, 73 (3) 900-908; DOI: https://doi.org/10.1124/mol.107.040089
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  N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts through a Novel Site as a Positive Allosteric Modulator of Group 1 Metabotropic Glutamate Receptors

  Yelin Chen, Cyril Goudet, Jean-Philippe Pin and P. Jeffrey Conn

  Molecular Pharmacology March 2008, 73 (3) 909-918; DOI: https://doi.org/10.1124/mol.107.040097
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  A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression

  Rajesh R. Nair, Hector Avila, Xujun Ma, Zhengxin Wang, Michelle Lennartz, Bryant G. Darnay, Douglas D. Boyd and Chunhong Yan

  Molecular Pharmacology March 2008, 73 (3) 919-929; DOI: https://doi.org/10.1124/mol.107.042606
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  Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induced by Picropodophyllin

  Radu Vasilcanu, Daiana Vasilcanu, Bita Sehat, Shucheng Yin, Ada Girnita, Magnus Axelson and Leonard Girnita

  Molecular Pharmacology March 2008, 73 (3) 930-939; DOI: https://doi.org/10.1124/mol.107.040014
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  State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na⁺ Channel Isoforms by Ranolazine

  Ging Kuo Wang, Joanna Calderon and Sho-Ya Wang

  Molecular Pharmacology March 2008, 73 (3) 940-948; DOI: https://doi.org/10.1124/mol.107.041541
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  The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Fetal Distribution of Glyburide in the Pregnant Mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study

  Lin Zhou, Suresh Babu Naraharisetti, Honggang Wang, Jashvant D. Unadkat, Mary F. Hebert and Qingcheng Mao

  Molecular Pharmacology March 2008, 73 (3) 949-959; DOI: https://doi.org/10.1124/mol.107.041616
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  Atomic Force Microscopy Reveals the Stoichiometry and Subunit Arrangement of the α₄β₃δ GABA_A Receptor

  Nelson P. Barrera, Jill Betts, Haitao You, Robert M. Henderson, Ian L. Martin, Susan M. J. Dunn and J. Michael Edwardson

  Molecular Pharmacology March 2008, 73 (3) 960-967; DOI: https://doi.org/10.1124/mol.107.042481
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  Modulation of Receptor Phosphorylation Contributes to Activation of Peroxisome Proliferator Activated Receptor α by Dehydroepiandrosterone and Other Peroxisome Proliferators

  Viola Tamasi, Kristy K. Michael Miller, Sharon L. Ripp, Ermin Vila, Thomas E. Geoghagen and Russell A. Prough

  Molecular Pharmacology March 2008, 73 (3) 968-976; DOI: https://doi.org/10.1124/mol.107.036780
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  N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator

  A. D. Wickenden, J. L. Krajewski, B. London, P. K. Wagoner, W. A. Wilson, S. Clark, R. Roeloffs, G. McNaughton-Smith and G. C. Rigdon

  Molecular Pharmacology March 2008, 73 (3) 977-986; DOI: https://doi.org/10.1124/mol.107.043216
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  A New Mechanism of 6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one Dihydrochloride (TAS-103) Action Discovered by Target Screening with Drug-Immobilized Affinity Beads

  Makoto Yoshida, Yasuaki Kabe, Tadashi Wada, Akira Asai and Hiroshi Handa

  Molecular Pharmacology March 2008, 73 (3) 987-994; DOI: https://doi.org/10.1124/mol.107.043307
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  Direct Role of Streptozotocin in Inducing Thermal Hyperalgesia by Enhanced Expression of Transient Receptor Potential Vanilloid 1 in Sensory Neurons

  Reddy M. Pabbidi, De-Shou Cao, Arti Parihar, Mary E. Pauza and Louis S. Premkumar

  Molecular Pharmacology March 2008, 73 (3) 995-1004; DOI: https://doi.org/10.1124/mol.107.041707
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  Combined Effects of Sulindac and Suberoylanilide Hydroxamic Acid on Apoptosis Induction in Human Lung Cancer Cells

  Sung-Keum Seo, Hyeon-Ok Jin, Hyung-Chahn Lee, Sang-Hyeok Woo, Eun-Sung Kim, Doo-Hyun Yoo, Su-Jae Lee, Sungkwan An, Chang-Hun Rhee, Seok-Il Hong, Tae-Boo Choe and In-Chul Park

  Molecular Pharmacology March 2008, 73 (3) 1005-1012; DOI: https://doi.org/10.1124/mol.107.041293
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  Analysis of Promoter Regions Regulating Basal and Interleukin-4-Inducible Expression of the Human CB1 Receptor Gene in T Lymphocytes

  Christine Börner, Andrea Bedini, Volker Höllt and Jürgen Kraus

  Molecular Pharmacology March 2008, 73 (3) 1013-1019; DOI: https://doi.org/10.1124/mol.107.042945
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  Inhibition of Sodium Channel Gating by Trapping the Domain II Voltage Sensor with Protoxin II

  Stanislav Sokolov, Richard L. Kraus, Todd Scheuer and William A. Catterall

  Molecular Pharmacology March 2008, 73 (3) 1020-1028; DOI: https://doi.org/10.1124/mol.107.041046
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  Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes

  Robert A. B. van Waterschoot, Antonius E. van Herwaarden, Jurjen S. Lagas, Rolf W. Sparidans, Els Wagenaar, Cornelia M. M. van der Kruijssen, Joyce A. Goldstein, Darryl C. Zeldin, Jos H. Beijnen and Alfred H. Schinkel

  Molecular Pharmacology March 2008, 73 (3) 1029-1036; DOI: https://doi.org/10.1124/mol.107.043869