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Molecular Pharmacology

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Table of Contents

April 01, 2008; Volume 73,Issue 4

Accelerated Communication

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    The RGS2 Gene Product from a Candidate Hypertension Allele Shows Decreased Plasma Membrane Association and Inhibition of Gq
    Steven Gu, Sam Tirgari and Scott P. Heximer
    Molecular Pharmacology April 2008, 73 (4) 1037-1043; DOI: https://doi.org/10.1124/mol.107.044214

Articles

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    A Single Amino Acid Difference between Ether-a-go-go- Related Gene Channel Subtypes Determines Differential Sensitivity to a Small Molecule Activator
    Matthew Perry and Michael C. Sanguinetti
    Molecular Pharmacology April 2008, 73 (4) 1044-1051; DOI: https://doi.org/10.1124/mol.107.043018
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    Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis
    Matthew A. King, Sarah Hands, Farida Hafiz, Noboru Mizushima, Aviva M. Tolkovsky and Andreas Wyttenbach
    Molecular Pharmacology April 2008, 73 (4) 1052-1063; DOI: https://doi.org/10.1124/mol.107.043398
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    Development of an Aryl Hydrocarbon Receptor Antagonist Using the Proteolysis-Targeting Chimeric Molecules Approach: A Potential Tool for Chemoprevention
    Dinesh Puppala, Hyosung Lee, Kyung Bo Kim and Hollie I. Swanson
    Molecular Pharmacology April 2008, 73 (4) 1064-1071; DOI: https://doi.org/10.1124/mol.107.040840
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    Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake
    Adam B. Weinglass, Martin G. Köhler, Emmanuel O. Nketiah, Jessica Liu, William Schmalhofer, Anu Thomas, Brande Williams, Lindsey Beers, Lauren Smith, Mike Hafey, Kelly Bleasby, Joseph Leone, Yui Sing Tang, Matthew Braun, Feroze Ujjainwalla, Margaret E. McCann, Gregory J. Kaczorowski and Maria L. Garcia
    Molecular Pharmacology April 2008, 73 (4) 1072-1084; DOI: https://doi.org/10.1124/mol.107.043844
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    Salicylate Alters the Expression of Calcium Response Transcription Factor 1 in the Cochlea: Implications for Brain-Derived Neurotrophic Factor Transcriptional Regulation
    Wibke Singer, Rama Panford-Walsh, Dirk Watermann, Oliver Hendrich, Ulrike Zimmermann, Iris Köpschall, Karin Rohbock and Marlies Knipper
    Molecular Pharmacology April 2008, 73 (4) 1085-1091; DOI: https://doi.org/10.1124/mol.107.041814
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    Wide Turn Diversity in Protein Transmembrane Helices Implications for G-Protein-Coupled Receptor and Other Polytopic Membrane Protein Structure and Function
    R. Peter Riek, Angela A. Finch, Gillian E. Begg and Robert M. Graham
    Molecular Pharmacology April 2008, 73 (4) 1092-1104; DOI: https://doi.org/10.1124/mol.107.043042
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    Dopamine and Ethanol Cause Translocation of ϵPKC Associated with ϵRACK: Cross-Talk between cAMP-Dependent Protein Kinase A and Protein Kinase C Signaling Pathways
    Lina Yao, Peidong Fan, Zhan Jiang, Adrienne Gordon, Daria Mochly-Rosen and Ivan Diamond
    Molecular Pharmacology April 2008, 73 (4) 1105-1112; DOI: https://doi.org/10.1124/mol.107.042580
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    PPP1R16A, The Membrane Subunit of Protein Phosphatase 1β, Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor
    Tatsuya Sueyoshi, Rick Moore, Junko Sugatani, Yonehiro Matsumura and Masahiko Negishi
    Molecular Pharmacology April 2008, 73 (4) 1113-1121; DOI: https://doi.org/10.1124/mol.107.042960
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    Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo
    Thien-An Nguyen, Marina Tychopoulos, Florence Bichat, Clothilde Zimmermann, Jean-Pierre Flinois, Monique Diry, Emelie Ahlberg, Marcel Delaforge, Laurent Corcos, Philippe Beaune, Patrick Dansette, François André and Isabelle de Waziers
    Molecular Pharmacology April 2008, 73 (4) 1122-1133; DOI: https://doi.org/10.1124/mol.107.042861
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    Effects of High-Affinity Inhibitors on Partial Reactions, Charge Movements, and Conformational States of the Ca2+ Transport ATPase (Sarco-Endoplasmic Reticulum Ca2+ ATPase)
    Francesco Tadini-Buoninsegni, Gianluca Bartolommei, Maria Rosa Moncelli, Daniel M. Tal, David Lewis and Giuseppe Inesi
    Molecular Pharmacology April 2008, 73 (4) 1134-1140; DOI: https://doi.org/10.1124/mol.107.043745
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    Labeling of Dopamine Transporter Transmembrane Domain 1 with the Tropane Ligand N-[4-(4-Azido-3-[125I]iodophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane Implicates Proximity of Cocaine and Substrate Active Sites
    M. Laura Parnas, Jon D. Gaffaney, Mu Fa Zou, John R. Lever, Amy Hauck Newman and Roxanne A. Vaughan
    Molecular Pharmacology April 2008, 73 (4) 1141-1150; DOI: https://doi.org/10.1124/mol.107.043679
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    Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP
    Cheryl D. Cropp, Takafumi Komori, James E. Shima, Thomas J. Urban, Sook Wah Yee, Swati S. More and Kathleen M. Giacomini
    Molecular Pharmacology April 2008, 73 (4) 1151-1158; DOI: https://doi.org/10.1124/mol.107.043117
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    Structural Basis for Ether-a-go-go-Related Gene K+ Channel Subtype-Dependent Activation by Niflumic Acid
    David Fernandez, John Sargent, Frank B. Sachse and Michael C. Sanguinetti
    Molecular Pharmacology April 2008, 73 (4) 1159-1167; DOI: https://doi.org/10.1124/mol.107.043505
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    OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells
    Margaret A. Park, Adly Yacoub, Mohammed Rahmani, Guo Zhang, Lori Hart, Michael P. Hagan, Stuart K. Calderwood, Michael Y. Sherman, Costas Koumenis, Sarah Spiegel, Ching-Shih Chen, Martin Graf, David T. Curiel, Paul B. Fisher, Steven Grant and Paul Dent
    Molecular Pharmacology April 2008, 73 (4) 1168-1184; DOI: https://doi.org/10.1124/mol.107.042697
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    Arachidonic Acid Activates Kir2.3 Channels by Enhancing Channel-Phosphatidyl-inositol 4,5-bisphosphate Interactions
    Chuan Wang, Uyenlinh L. Mirshahi, Boyi Liu, Zhanfeng Jia, Tooraj Mirshahi and Hailin Zhang
    Molecular Pharmacology April 2008, 73 (4) 1185-1194; DOI: https://doi.org/10.1124/mol.107.043067
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    α2 Subunit Specificity of Cyclothiazide Inhibition on Glycine Receptors
    Xiao-Bing Zhang, Guang-Chun Sun, Lu-Ying Liu, Fang Yu and Tian-Le Xu
    Molecular Pharmacology April 2008, 73 (4) 1195-1202; DOI: https://doi.org/10.1124/mol.107.042655
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    Enhanced Excitation-Coupled Calcium Entry in Myotubes Expressing Malignant Hyperthermia Mutation R163C Is Attenuated by Dantrolene
    Gennady Cherednichenko, Chris W. Ward, Wei Feng, Elaine Cabrales, Luke Michaelson, Montserrat Samso, José R. López, Paul D. Allen and Isaac N. Pessah
    Molecular Pharmacology April 2008, 73 (4) 1203-1212; DOI: https://doi.org/10.1124/mol.107.043299
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    A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors
    Colleen M. Niswender, Kari A. Johnson, Qingwei Luo, Jennifer E. Ayala, Caroline Kim, P. Jeffrey Conn and C. David Weaver
    Molecular Pharmacology April 2008, 73 (4) 1213-1224; DOI: https://doi.org/10.1124/mol.107.041053
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    Activation of TRPA1 by Farnesyl Thiosalicylic Acid
    Michael Maher, Hong Ao, Tue Banke, Nadia Nasser, Nyan-Tsz Wu, J. Guy Breitenbucher, Sandra R. Chaplan and Alan D. Wickenden
    Molecular Pharmacology April 2008, 73 (4) 1225-1234; DOI: https://doi.org/10.1124/mol.107.042663
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    Pharmacological and Kinetic Characterization of Adrenomedullin 1 and Calcitonin Gene-Related Peptide 1 Receptor Reporter Cell Lines
    Frank Wunder, Annegret Rebmann, Andreas Geerts and Bernd Kalthof
    Molecular Pharmacology April 2008, 73 (4) 1235-1243; DOI: https://doi.org/10.1124/mol.107.042283
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    BYK191023 (2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) Is an NADPH- and Time-Dependent Irreversible Inhibitor of Inducible Nitric-Oxide Synthase
    Mauro Tiso, Andreas Strub, Christian Hesslinger, Claire T. Kenney, Rainer Boer and Dennis J. Stuehr
    Molecular Pharmacology April 2008, 73 (4) 1244-1253; DOI: https://doi.org/10.1124/mol.107.041319
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    Modulation of Na+-Ca2+ Exchanger Expression by Immunosuppressive Drugs Is Isoform-Specific
    Benayahu Elbaz, Ariella Alperovitch, Michael M. Gottesman, Chava Kimchi-Sarfaty and Hannah Rahamimoff
    Molecular Pharmacology April 2008, 73 (4) 1254-1263; DOI: https://doi.org/10.1124/mol.107.041582
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    Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026
    Gemma Moncunill, Mercedes Armand-Ugón, Imma Clotet-Codina, Eduardo Pauls, Ester Ballana, Anuska Llano, Barbara Romagnoli, Jan W. Vrijbloed, Frank O. Gombert, Bonaventura Clotet, Steve De Marco and José A. Esté
    Molecular Pharmacology April 2008, 73 (4) 1264-1273; DOI: https://doi.org/10.1124/mol.107.042911
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    Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition
    Yijun Deng, Zhanjun Hou, Lei Wang, Christina Cherian, Jianmei Wu, Aleem Gangjee and Larry H. Matherly
    Molecular Pharmacology April 2008, 73 (4) 1274-1281; DOI: https://doi.org/10.1124/mol.107.043190
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    Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression
    Adrian Roth, Renate Looser, Michel Kaufmann, Sharon M. Blättler, Franck Rencurel, Wendong Huang, David D. Moore and Urs A. Meyer
    Molecular Pharmacology April 2008, 73 (4) 1282-1289; DOI: https://doi.org/10.1124/mol.107.041012
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    Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells
    Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A. Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone and Godefridus J. Peters
    Molecular Pharmacology April 2008, 73 (4) 1290-1300; DOI: https://doi.org/10.1124/mol.107.042382
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    Agonist-Specific Regulation of μ-Opioid Receptor Desensitization and Recovery from Desensitization
    Michael S. Virk and John T. Williams
    Molecular Pharmacology April 2008, 73 (4) 1301-1308; DOI: https://doi.org/10.1124/mol.107.042952
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    Benzoxathiole Derivative Blocks Lipopolysaccharide-Induced Nuclear Factor-κB Activation and Nuclear Factor-κB-Regulated Gene Transcription through Inactivating Inhibitory κB Kinase β
    Byung Hak Kim, Eunmiri Roh, Hwa Young Lee, In-Jeong Lee, Byeongwoo Ahn, Sang-Hun Jung, Heesoon Lee, Sang-Bae Han and Youngsoo Kim
    Molecular Pharmacology April 2008, 73 (4) 1309-1318; DOI: https://doi.org/10.1124/mol.107.041251
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    Agonist-Promoted Lys63-Linked Polyubiquitination of the Human κ-Opioid Receptor Is Involved in Receptor Down-Regulation
    Jian-Guo Li, Dale S. Haines and Lee-Yuan Liu-Chen
    Molecular Pharmacology April 2008, 73 (4) 1319-1330; DOI: https://doi.org/10.1124/mol.107.042846

Erratum

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    Correction to “Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression”
    Molecular Pharmacology April 2008, 73 (4) 1331; DOI: https://doi.org/10.1124/mol.73.4.1331
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Molecular Pharmacology: 73 (4)
Molecular Pharmacology
Vol. 73, Issue 4
1 Apr 2008
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