Table of Contents

Articles

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  A Single Amino Acid Difference between Ether-a-go-go- Related Gene Channel Subtypes Determines Differential Sensitivity to a Small Molecule Activator

  Matthew Perry and Michael C. Sanguinetti

  Molecular Pharmacology April 2008, 73 (4) 1044-1051; DOI: https://doi.org/10.1124/mol.107.043018
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  Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

  Matthew A. King, Sarah Hands, Farida Hafiz, Noboru Mizushima, Aviva M. Tolkovsky and Andreas Wyttenbach

  Molecular Pharmacology April 2008, 73 (4) 1052-1063; DOI: https://doi.org/10.1124/mol.107.043398
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  Development of an Aryl Hydrocarbon Receptor Antagonist Using the Proteolysis-Targeting Chimeric Molecules Approach: A Potential Tool for Chemoprevention

  Dinesh Puppala, Hyosung Lee, Kyung Bo Kim and Hollie I. Swanson

  Molecular Pharmacology April 2008, 73 (4) 1064-1071; DOI: https://doi.org/10.1124/mol.107.040840
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  Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake

  Adam B. Weinglass, Martin G. Köhler, Emmanuel O. Nketiah, Jessica Liu, William Schmalhofer, Anu Thomas, Brande Williams, Lindsey Beers, Lauren Smith, Mike Hafey, Kelly Bleasby, Joseph Leone, Yui Sing Tang, Matthew Braun, Feroze Ujjainwalla, Margaret E. McCann, Gregory J. Kaczorowski and Maria L. Garcia

  Molecular Pharmacology April 2008, 73 (4) 1072-1084; DOI: https://doi.org/10.1124/mol.107.043844
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  Salicylate Alters the Expression of Calcium Response Transcription Factor 1 in the Cochlea: Implications for Brain-Derived Neurotrophic Factor Transcriptional Regulation

  Wibke Singer, Rama Panford-Walsh, Dirk Watermann, Oliver Hendrich, Ulrike Zimmermann, Iris Köpschall, Karin Rohbock and Marlies Knipper

  Molecular Pharmacology April 2008, 73 (4) 1085-1091; DOI: https://doi.org/10.1124/mol.107.041814
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  Wide Turn Diversity in Protein Transmembrane Helices Implications for G-Protein-Coupled Receptor and Other Polytopic Membrane Protein Structure and Function

  R. Peter Riek, Angela A. Finch, Gillian E. Begg and Robert M. Graham

  Molecular Pharmacology April 2008, 73 (4) 1092-1104; DOI: https://doi.org/10.1124/mol.107.043042
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  Dopamine and Ethanol Cause Translocation of ϵPKC Associated with ϵRACK: Cross-Talk between cAMP-Dependent Protein Kinase A and Protein Kinase C Signaling Pathways

  Lina Yao, Peidong Fan, Zhan Jiang, Adrienne Gordon, Daria Mochly-Rosen and Ivan Diamond

  Molecular Pharmacology April 2008, 73 (4) 1105-1112; DOI: https://doi.org/10.1124/mol.107.042580
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  PPP1R16A, The Membrane Subunit of Protein Phosphatase 1β, Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor

  Tatsuya Sueyoshi, Rick Moore, Junko Sugatani, Yonehiro Matsumura and Masahiko Negishi

  Molecular Pharmacology April 2008, 73 (4) 1113-1121; DOI: https://doi.org/10.1124/mol.107.042960
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  Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo

  Thien-An Nguyen, Marina Tychopoulos, Florence Bichat, Clothilde Zimmermann, Jean-Pierre Flinois, Monique Diry, Emelie Ahlberg, Marcel Delaforge, Laurent Corcos, Philippe Beaune, Patrick Dansette, François André and Isabelle de Waziers

  Molecular Pharmacology April 2008, 73 (4) 1122-1133; DOI: https://doi.org/10.1124/mol.107.042861
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  Effects of High-Affinity Inhibitors on Partial Reactions, Charge Movements, and Conformational States of the Ca²⁺ Transport ATPase (Sarco-Endoplasmic Reticulum Ca²⁺ ATPase)

  Francesco Tadini-Buoninsegni, Gianluca Bartolommei, Maria Rosa Moncelli, Daniel M. Tal, David Lewis and Giuseppe Inesi

  Molecular Pharmacology April 2008, 73 (4) 1134-1140; DOI: https://doi.org/10.1124/mol.107.043745
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  Labeling of Dopamine Transporter Transmembrane Domain 1 with the Tropane Ligand N-[4-(4-Azido-3-[¹²⁵I]iodophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane Implicates Proximity of Cocaine and Substrate Active Sites

  M. Laura Parnas, Jon D. Gaffaney, Mu Fa Zou, John R. Lever, Amy Hauck Newman and Roxanne A. Vaughan

  Molecular Pharmacology April 2008, 73 (4) 1141-1150; DOI: https://doi.org/10.1124/mol.107.043679
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  Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP

  Cheryl D. Cropp, Takafumi Komori, James E. Shima, Thomas J. Urban, Sook Wah Yee, Swati S. More and Kathleen M. Giacomini

  Molecular Pharmacology April 2008, 73 (4) 1151-1158; DOI: https://doi.org/10.1124/mol.107.043117
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  Structural Basis for Ether-a-go-go-Related Gene K⁺ Channel Subtype-Dependent Activation by Niflumic Acid

  David Fernandez, John Sargent, Frank B. Sachse and Michael C. Sanguinetti

  Molecular Pharmacology April 2008, 73 (4) 1159-1167; DOI: https://doi.org/10.1124/mol.107.043505
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  OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

  Margaret A. Park, Adly Yacoub, Mohammed Rahmani, Guo Zhang, Lori Hart, Michael P. Hagan, Stuart K. Calderwood, Michael Y. Sherman, Costas Koumenis, Sarah Spiegel, Ching-Shih Chen, Martin Graf, David T. Curiel, Paul B. Fisher, Steven Grant and Paul Dent

  Molecular Pharmacology April 2008, 73 (4) 1168-1184; DOI: https://doi.org/10.1124/mol.107.042697
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  Arachidonic Acid Activates Kir2.3 Channels by Enhancing Channel-Phosphatidyl-inositol 4,5-bisphosphate Interactions

  Chuan Wang, Uyenlinh L. Mirshahi, Boyi Liu, Zhanfeng Jia, Tooraj Mirshahi and Hailin Zhang

  Molecular Pharmacology April 2008, 73 (4) 1185-1194; DOI: https://doi.org/10.1124/mol.107.043067
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  α2 Subunit Specificity of Cyclothiazide Inhibition on Glycine Receptors

  Xiao-Bing Zhang, Guang-Chun Sun, Lu-Ying Liu, Fang Yu and Tian-Le Xu

  Molecular Pharmacology April 2008, 73 (4) 1195-1202; DOI: https://doi.org/10.1124/mol.107.042655
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  Enhanced Excitation-Coupled Calcium Entry in Myotubes Expressing Malignant Hyperthermia Mutation R163C Is Attenuated by Dantrolene

  Gennady Cherednichenko, Chris W. Ward, Wei Feng, Elaine Cabrales, Luke Michaelson, Montserrat Samso, José R. López, Paul D. Allen and Isaac N. Pessah

  Molecular Pharmacology April 2008, 73 (4) 1203-1212; DOI: https://doi.org/10.1124/mol.107.043299
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  A Novel Assay of G_i/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

  Colleen M. Niswender, Kari A. Johnson, Qingwei Luo, Jennifer E. Ayala, Caroline Kim, P. Jeffrey Conn and C. David Weaver

  Molecular Pharmacology April 2008, 73 (4) 1213-1224; DOI: https://doi.org/10.1124/mol.107.041053
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  Activation of TRPA1 by Farnesyl Thiosalicylic Acid

  Michael Maher, Hong Ao, Tue Banke, Nadia Nasser, Nyan-Tsz Wu, J. Guy Breitenbucher, Sandra R. Chaplan and Alan D. Wickenden

  Molecular Pharmacology April 2008, 73 (4) 1225-1234; DOI: https://doi.org/10.1124/mol.107.042663
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  Pharmacological and Kinetic Characterization of Adrenomedullin 1 and Calcitonin Gene-Related Peptide 1 Receptor Reporter Cell Lines

  Frank Wunder, Annegret Rebmann, Andreas Geerts and Bernd Kalthof

  Molecular Pharmacology April 2008, 73 (4) 1235-1243; DOI: https://doi.org/10.1124/mol.107.042283
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  BYK191023 (2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) Is an NADPH- and Time-Dependent Irreversible Inhibitor of Inducible Nitric-Oxide Synthase

  Mauro Tiso, Andreas Strub, Christian Hesslinger, Claire T. Kenney, Rainer Boer and Dennis J. Stuehr

  Molecular Pharmacology April 2008, 73 (4) 1244-1253; DOI: https://doi.org/10.1124/mol.107.041319
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  Modulation of Na⁺-Ca²⁺ Exchanger Expression by Immunosuppressive Drugs Is Isoform-Specific

  Benayahu Elbaz, Ariella Alperovitch, Michael M. Gottesman, Chava Kimchi-Sarfaty and Hannah Rahamimoff

  Molecular Pharmacology April 2008, 73 (4) 1254-1263; DOI: https://doi.org/10.1124/mol.107.041582
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  Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026

  Gemma Moncunill, Mercedes Armand-Ugón, Imma Clotet-Codina, Eduardo Pauls, Ester Ballana, Anuska Llano, Barbara Romagnoli, Jan W. Vrijbloed, Frank O. Gombert, Bonaventura Clotet, Steve De Marco and José A. Esté

  Molecular Pharmacology April 2008, 73 (4) 1264-1273; DOI: https://doi.org/10.1124/mol.107.042911
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  Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition

  Yijun Deng, Zhanjun Hou, Lei Wang, Christina Cherian, Jianmei Wu, Aleem Gangjee and Larry H. Matherly

  Molecular Pharmacology April 2008, 73 (4) 1274-1281; DOI: https://doi.org/10.1124/mol.107.043190
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  Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

  Adrian Roth, Renate Looser, Michel Kaufmann, Sharon M. Blättler, Franck Rencurel, Wendong Huang, David D. Moore and Urs A. Meyer

  Molecular Pharmacology April 2008, 73 (4) 1282-1289; DOI: https://doi.org/10.1124/mol.107.041012
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  Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells

  Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A. Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone and Godefridus J. Peters

  Molecular Pharmacology April 2008, 73 (4) 1290-1300; DOI: https://doi.org/10.1124/mol.107.042382
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  Agonist-Specific Regulation of μ-Opioid Receptor Desensitization and Recovery from Desensitization

  Michael S. Virk and John T. Williams

  Molecular Pharmacology April 2008, 73 (4) 1301-1308; DOI: https://doi.org/10.1124/mol.107.042952
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  Benzoxathiole Derivative Blocks Lipopolysaccharide-Induced Nuclear Factor-κB Activation and Nuclear Factor-κB-Regulated Gene Transcription through Inactivating Inhibitory κB Kinase β

  Byung Hak Kim, Eunmiri Roh, Hwa Young Lee, In-Jeong Lee, Byeongwoo Ahn, Sang-Hun Jung, Heesoon Lee, Sang-Bae Han and Youngsoo Kim

  Molecular Pharmacology April 2008, 73 (4) 1309-1318; DOI: https://doi.org/10.1124/mol.107.041251
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  Agonist-Promoted Lys63-Linked Polyubiquitination of the Human κ-Opioid Receptor Is Involved in Receptor Down-Regulation

  Jian-Guo Li, Dale S. Haines and Lee-Yuan Liu-Chen

  Molecular Pharmacology April 2008, 73 (4) 1319-1330; DOI: https://doi.org/10.1124/mol.107.042846