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Research ArticleCommentary

Crystallizing Thinking about the β2-Adrenergic Receptor

Arun K. Shukla, Jin-Peng Sun and Robert J. Lefkowitz
Molecular Pharmacology May 2008, 73 (5) 1333-1338; DOI: https://doi.org/10.1124/mol.108.045849
Arun K. Shukla
Department of Medicine (A.K.S., J.-P.S., R.J.L.), and Department of Biochemistry (A.K.S., J.-P.S., R.J.L.) and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina
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Jin-Peng Sun
Department of Medicine (A.K.S., J.-P.S., R.J.L.), and Department of Biochemistry (A.K.S., J.-P.S., R.J.L.) and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina
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Robert J. Lefkowitz
Department of Medicine (A.K.S., J.-P.S., R.J.L.), and Department of Biochemistry (A.K.S., J.-P.S., R.J.L.) and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina
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Abstract

Two recently determined crystal structures of the human β2-adrenergic receptor (β2AR) provide a long-awaited advance in the field of G protein-coupled receptor research. The β2AR is only the second member of this, the largest family of receptors encoded in the human genome, whose structure has been solved. It follows structures of rhodopsin that were determined previously. Here we set these developments in historical context, discuss the daunting challenges that have been overcome, and appraise what has and has not been learned.

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Molecular Pharmacology: 73 (5)
Molecular Pharmacology
Vol. 73, Issue 5
1 May 2008
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Research ArticleCommentary

Crystallizing Thinking about the β2-Adrenergic Receptor

Arun K. Shukla, Jin-Peng Sun and Robert J. Lefkowitz
Molecular Pharmacology May 1, 2008, 73 (5) 1333-1338; DOI: https://doi.org/10.1124/mol.108.045849

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Research ArticleCommentary

Crystallizing Thinking about the β2-Adrenergic Receptor

Arun K. Shukla, Jin-Peng Sun and Robert J. Lefkowitz
Molecular Pharmacology May 1, 2008, 73 (5) 1333-1338; DOI: https://doi.org/10.1124/mol.108.045849
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  • Article
    • Abstract
    • Why Did It Take So Long?
    • What Made It Possible?
    • Why the β2AR Rather Than Others?
    • How Similar Is the Structure to That of Rhodopsin?
    • What Does the Structure Teach Us?
    • What Conformation Is the Receptor in?
    • What Do the Structures Not Tell Us?
    • Future Directions?
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