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Molecular Pharmacology

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Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex

Giancarlo A. Biagini, Nicholas Fisher, Neil Berry, Paul A. Stocks, Brigitte Meunier, Dominic P. Williams, Richard Bonar-Law, Patrick G. Bray, Andrew Owen, Paul M. O'Neill and Stephen A. Ward
Molecular Pharmacology May 2008, 73 (5) 1347-1355; DOI: https://doi.org/10.1124/mol.108.045120
Giancarlo A. Biagini
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Nicholas Fisher
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Neil Berry
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Paul A. Stocks
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Brigitte Meunier
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Dominic P. Williams
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Richard Bonar-Law
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Patrick G. Bray
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Andrew Owen
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Paul M. O'Neill
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Stephen A. Ward
Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
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Article Information

vol. 73 no. 5 1347-1355
DOI 
https://doi.org/10.1124/mol.108.045120
PubMed 
18319379

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received January 10, 2008
  • Accepted February 29, 2008
  • Published online April 16, 2008.

Article Versions

  • Earlier version (March 4, 2008 - 10:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Giancarlo A. Biagini,
  2. Nicholas Fisher,
  3. Neil Berry,
  4. Paul A. Stocks,
  5. Brigitte Meunier,
  6. Dominic P. Williams,
  7. Richard Bonar-Law,
  8. Patrick G. Bray,
  9. Andrew Owen,
  10. Paul M. O'Neill, and
  11. Stephen A. Ward
  1. Liverpool School of Tropical Medicine, Liverpool, United Kingdom (G.A.B., N.F., P.A.S., P.G.B., S.A.W.). Departments of Chemistry (N.B., R.B.-L., P.M.O.) and Pharmacology and Therapeutics (D.P.W., A.O.), University of Liverpool, Liverpool, United Kingdom; and Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France (B.M.)
  1. Address correspondence to:
    Giancarlo A. Biagini, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. E-mail: biagini{at}liv.ac.uk
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Molecular Pharmacology: 73 (5)
Molecular Pharmacology
Vol. 73, Issue 5
1 May 2008
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Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex

Giancarlo A. Biagini, Nicholas Fisher, Neil Berry, Paul A. Stocks, Brigitte Meunier, Dominic P. Williams, Richard Bonar-Law, Patrick G. Bray, Andrew Owen, Paul M. O'Neill and Stephen A. Ward
Molecular Pharmacology May 1, 2008, 73 (5) 1347-1355; DOI: https://doi.org/10.1124/mol.108.045120

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Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex

Giancarlo A. Biagini, Nicholas Fisher, Neil Berry, Paul A. Stocks, Brigitte Meunier, Dominic P. Williams, Richard Bonar-Law, Patrick G. Bray, Andrew Owen, Paul M. O'Neill and Stephen A. Ward
Molecular Pharmacology May 1, 2008, 73 (5) 1347-1355; DOI: https://doi.org/10.1124/mol.108.045120
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