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Molecular Pharmacology

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OtherAccelerated Communication

Regulation of Smad-Mediated Gene Transcription by RGS3

Douglas M. Yau, Nan Sethakorn, Sebastien Taurin, Steven Kregel, Nathan Sandbo, Blanca Camoretti-Mercado, Anne I. Sperling and Nickolai O. Dulin
Molecular Pharmacology May 2008, 73 (5) 1356-1361; DOI: https://doi.org/10.1124/mol.108.044990
Douglas M. Yau
Department of Medicine, the University of Chicago, Chicago, Illinois
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Nan Sethakorn
Department of Medicine, the University of Chicago, Chicago, Illinois
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Sebastien Taurin
Department of Medicine, the University of Chicago, Chicago, Illinois
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Steven Kregel
Department of Medicine, the University of Chicago, Chicago, Illinois
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Nathan Sandbo
Department of Medicine, the University of Chicago, Chicago, Illinois
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Blanca Camoretti-Mercado
Department of Medicine, the University of Chicago, Chicago, Illinois
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Anne I. Sperling
Department of Medicine, the University of Chicago, Chicago, Illinois
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Nickolai O. Dulin
Department of Medicine, the University of Chicago, Chicago, Illinois
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Abstract

Regulator of G protein signaling (RGS) proteins are united into a family by the presence of the homologous RGS domain that binds the α subunits of heterotrimeric G proteins and accelerates their GTPase activity. A member of this family, RGS3 regulates the signaling mediated by Gq and Gi proteins by binding the corresponding Gα subunits. Here we show that RGS3 interacts with the novel partners Smad2, Smad3, and Smad4—the transcription factors that are activated through a transforming growth factor-β (TGF-β) receptor signaling. This interaction is mediated by the region of RGS3 outside of the RGS domain and by Smad's Mad homology 2 domain. Overexpression of RGS3 results in inhibition of Smad-mediated gene transcription. RGS3 does not affect TGF-β-induced Smad phosphorylation, but it prevents heteromerization of Smad3 with Smad4, which is required for transcriptional activity of Smads. This translates to functional inhibition of TGF-β-induced myofibroblast differentiation by RGS3. In conclusion, this study identifies a novel, noncanonical role of RGS3 in regulation of TGF-β signaling through its interaction with Smads and interfering with Smad heteromerization.

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Molecular Pharmacology: 73 (5)
Molecular Pharmacology
Vol. 73, Issue 5
1 May 2008
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OtherAccelerated Communication

Regulation of Smad-Mediated Gene Transcription by RGS3

Douglas M. Yau, Nan Sethakorn, Sebastien Taurin, Steven Kregel, Nathan Sandbo, Blanca Camoretti-Mercado, Anne I. Sperling and Nickolai O. Dulin
Molecular Pharmacology May 1, 2008, 73 (5) 1356-1361; DOI: https://doi.org/10.1124/mol.108.044990

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OtherAccelerated Communication

Regulation of Smad-Mediated Gene Transcription by RGS3

Douglas M. Yau, Nan Sethakorn, Sebastien Taurin, Steven Kregel, Nathan Sandbo, Blanca Camoretti-Mercado, Anne I. Sperling and Nickolai O. Dulin
Molecular Pharmacology May 1, 2008, 73 (5) 1356-1361; DOI: https://doi.org/10.1124/mol.108.044990
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