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Research ArticleArticle

Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

Ibolya E. András, GeunBae Rha, Wen Huang, SungYong Eum, Pierre-Olivier Couraud, Ignacio A. Romero, Bernhard Hennig and Michal Toborek
Molecular Pharmacology May 2008, 73 (5) 1424-1433; DOI: https://doi.org/10.1124/mol.107.042028
Ibolya E. András
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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GeunBae Rha
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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Wen Huang
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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SungYong Eum
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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Pierre-Olivier Couraud
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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Ignacio A. Romero
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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Bernhard Hennig
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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Michal Toborek
Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
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Article Information

vol. 73 no. 5 1424-1433
DOI 
https://doi.org/10.1124/mol.107.042028
PubMed 
18276775

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 20, 2007
  • Accepted February 14, 2008
  • Published online April 16, 2008.

Article Versions

  • Earlier version (February 14, 2008 - 07:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ibolya E. András,
  2. GeunBae Rha,
  3. Wen Huang,
  4. SungYong Eum,
  5. Pierre-Olivier Couraud,
  6. Ignacio A. Romero,
  7. Bernhard Hennig, and
  8. Michal Toborek
  1. Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery (I.E.A., G.B.R., W.H., S.Y.E., M.T.) and College of Agriculture (B.H.), University of Kentucky, Lexington, Kentucky; Institut COCHIN, Institut National de la Santé et de la Recherche Médicale U567, Paris, France (P.-O.C.); and Department of Life Sciences, the Open University, Milton Keynes, United Kingdom (I.A.R.)
  1. Address correspondence to:
    Dr. Michal Toborek, Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, 593 Wethington Bldg., 900 S Limestone, Lexington, KY 40536. E-mail: michal.toborek{at}uky.edu
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Molecular Pharmacology: 73 (5)
Molecular Pharmacology
Vol. 73, Issue 5
1 May 2008
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Research ArticleArticle

Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

Ibolya E. András, GeunBae Rha, Wen Huang, SungYong Eum, Pierre-Olivier Couraud, Ignacio A. Romero, Bernhard Hennig and Michal Toborek
Molecular Pharmacology May 1, 2008, 73 (5) 1424-1433; DOI: https://doi.org/10.1124/mol.107.042028

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Research ArticleArticle

Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

Ibolya E. András, GeunBae Rha, Wen Huang, SungYong Eum, Pierre-Olivier Couraud, Ignacio A. Romero, Bernhard Hennig and Michal Toborek
Molecular Pharmacology May 1, 2008, 73 (5) 1424-1433; DOI: https://doi.org/10.1124/mol.107.042028
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