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Research ArticleArticle

Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

Soichiro Matsushima, Kazuya Maeda, Hisamitsu Hayashi, Yasuyuki Debori, Alfred H. Schinkel, John D. Schuetz, Hiroyuki Kusuhara and Yuichi Sugiyama
Molecular Pharmacology May 2008, 73 (5) 1474-1483; DOI: https://doi.org/10.1124/mol.107.041459
Soichiro Matsushima
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Kazuya Maeda
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Hisamitsu Hayashi
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Yasuyuki Debori
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Alfred H. Schinkel
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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John D. Schuetz
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Hiroyuki Kusuhara
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Yuichi Sugiyama
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
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Article Information

vol. 73 no. 5 1474-1483
DOI 
https://doi.org/10.1124/mol.107.041459
PubMed 
18245269

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 3, 2007
  • Accepted February 1, 2008
  • Published online April 16, 2008.

Article Versions

  • Earlier version (February 1, 2008 - 08:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Soichiro Matsushima,
  2. Kazuya Maeda,
  3. Hisamitsu Hayashi,
  4. Yasuyuki Debori,
  5. Alfred H. Schinkel,
  6. John D. Schuetz,
  7. Hiroyuki Kusuhara, and
  8. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan. (S.M., K.M., H.H., Y.D., H.K., Y.S.); Division of Experimental Therapy, the Netherlands Cancer Institute, Amsterdam, the Netherlands (A.H.S.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Molecular Pharmacology: 73 (5)
Molecular Pharmacology
Vol. 73, Issue 5
1 May 2008
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Research ArticleArticle

Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

Soichiro Matsushima, Kazuya Maeda, Hisamitsu Hayashi, Yasuyuki Debori, Alfred H. Schinkel, John D. Schuetz, Hiroyuki Kusuhara and Yuichi Sugiyama
Molecular Pharmacology May 1, 2008, 73 (5) 1474-1483; DOI: https://doi.org/10.1124/mol.107.041459

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Research ArticleArticle

Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

Soichiro Matsushima, Kazuya Maeda, Hisamitsu Hayashi, Yasuyuki Debori, Alfred H. Schinkel, John D. Schuetz, Hiroyuki Kusuhara and Yuichi Sugiyama
Molecular Pharmacology May 1, 2008, 73 (5) 1474-1483; DOI: https://doi.org/10.1124/mol.107.041459
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