Table of Contents

Articles

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  Activation of Corticotropin-Releasing Factor Receptor 1 Selectively Inhibits Ca_V3.2 T-Type Calcium Channels

  Jin Tao, Michael E. Hildebrand, Ping Liao, Mui Cheng Liang, Gregory Tan, Shengnan Li, Terrance P. Snutch and Tuck Wah Soong

  Molecular Pharmacology June 2008, 73 (6) 1596-1609; DOI: https://doi.org/10.1124/mol.107.043612
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  Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related (GITR)-Fc Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response after Spinal Cord Injury

  Giuseppe Nocentini, Salvatore Cuzzocrea, Tiziana Genovese, Rodolfo Bianchini, Emanuela Mazzon, Simona Ronchetti, Emanuela Esposito, Di Paola Rosanna, Placido Bramanti and Carlo Riccardi

  Molecular Pharmacology June 2008, 73 (6) 1610-1621; DOI: https://doi.org/10.1124/mol.107.044354
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  Protease-Activated Receptor-1 Mediates Thrombin-Induced Persistent Sodium Current in Human Cardiomyocytes

  Caroline Pinet, Vincent Algalarrondo, Sylvie Sablayrolles, Bruno Le Grand, Christophe Pignier, Didier Cussac, Michel Perez, Stephane N. Hatem and Alain Coulombe

  Molecular Pharmacology June 2008, 73 (6) 1622-1631; DOI: https://doi.org/10.1124/mol.107.043182
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  Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-X_L Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck

  Amanda L. Boehm, Malabika Sen, Raja Seethala, William E. Gooding, Maria Freilino, Silvia Man Yan Wong, Shaomeng Wang, Daniel E. Johnson and Jennifer Rubin Grandis

  Molecular Pharmacology June 2008, 73 (6) 1632-1642; DOI: https://doi.org/10.1124/mol.107.044636
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  Topological Mapping of the Asymmetric Drug Binding to the Human Ether-à-go-go-Related Gene Product (HERG) Potassium Channel by Use of Tandem Dimers

  Toshihiko Myokai, Sunghi Ryu, Hirofumi Shimizu and Shigetoshi Oiki

  Molecular Pharmacology June 2008, 73 (6) 1643-1651; DOI: https://doi.org/10.1124/mol.107.042085
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  The Nuclear Factor-κB Pathway Regulates Cytochrome P450 3A4 Protein Stability

  R. C. Zangar, N. Bollinger, S. Verma, N. J. Karin and Y. Lu

  Molecular Pharmacology June 2008, 73 (6) 1652-1658; DOI: https://doi.org/10.1124/mol.107.043976
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  A Role for Leu118 of Loop E in Agonist Binding to the α7 Nicotinic Acetylcholine Receptor

  Shiva Amiri, Masaru Shimomura, Ranjit Vijayan, Hisashi Nishiwaki, Miki Akamatsu, Kazuhiko Matsuda, Andrew K. Jones, Mark S. P. Sansom, Philip C. Biggin and David B. Sattelle

  Molecular Pharmacology June 2008, 73 (6) 1659-1667; DOI: https://doi.org/10.1124/mol.107.041590
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  Multipathway Model Enables Prediction of Kinase Inhibitor Cross-Talk Effects on Migration of Her2-Overexpressing Mammary Epithelial Cells

  Neil Kumar, Raffi Afeyan, Hyung-Do Kim and Douglas A. Lauffenburger

  Molecular Pharmacology June 2008, 73 (6) 1668-1678; DOI: https://doi.org/10.1124/mol.107.043794
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  Inhibition of c-Myc Down-Regulation by Sustained Extracellular Signal-Regulated Kinase Activation Prevents the Antimetabolite Methotrexate- and Gemcitabine-Induced Differentiation in Non-Small-Cell Lung Cancer Cells

  Jordi M. Serra, Antonio Gutiérrez, Regina Alemany, María Navarro, Teresa Ros, Carlos Saus, Jordi Ginés, Antonia Sampol, Juan Carlos Amat, Lorenzo Serra-Moisés, Javier Martín, Antonio Galmés, Oliver Vögler and Joan Besalduch

  Molecular Pharmacology June 2008, 73 (6) 1679-1687; DOI: https://doi.org/10.1124/mol.107.043372
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  A cAMP-Dependent, Protein Kinase A-Independent Signaling Pathway Mediating Neuritogenesis through Egr1 in PC12 Cells

  Aurélia Ravni, David Vaudry, Matthew J. Gerdin, Maribeth V. Eiden, Anthony Falluel-Morel, Bruno J. Gonzalez, Hubert Vaudry and Lee E. Eiden

  Molecular Pharmacology June 2008, 73 (6) 1688-1708; DOI: https://doi.org/10.1124/mol.107.044792
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  Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

  Xulin Xu, Maurizio Recanatini, Marinella Roberti and Gea-Ny Tseng

  Molecular Pharmacology June 2008, 73 (6) 1709-1721; DOI: https://doi.org/10.1124/mol.108.045591
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  Primary Peripheral T Cells Become Susceptible to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Mediated Apoptosis in Vitro upon Activation and in the Presence of Dendritic Cells

  Narendra P. Singh, Mitzi Nagarkatti and Prakash Nagarkatti

  Molecular Pharmacology June 2008, 73 (6) 1722-1735; DOI: https://doi.org/10.1124/mol.107.043406
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  Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains

  Pari Malherbe, Caterina Bissantz, Anne Marcuz, Claudia Kratzeisen, Marie-Thérèse Zenner, Joseph G. Wettstein, Hasane Ratni, Claus Riemer and Will Spooren

  Molecular Pharmacology June 2008, 73 (6) 1736-1750; DOI: https://doi.org/10.1124/mol.107.042754
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  Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression

  Melissa A. Kramer, Allan E. Rettie, Mark J. Rieder, Erwin T. Cabacungan and Ronald N. Hines

  Molecular Pharmacology June 2008, 73 (6) 1751-1760; DOI: https://doi.org/10.1124/mol.107.044149
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  Identification of the Xenobiotic-Metabolizing Enzyme Arylamine N-Acetyltransferase 1 as a New Target of Cisplatin in Breast Cancer Cells: Molecular and Cellular Mechanisms of Inhibition

  Nilusha Ragunathan, Julien Dairou, Benjamin Pluvinage, Marta Martins, Emile Petit, Nathalie Janel, Jean-Marie Dupret and Fernando Rodrigues-Lima

  Molecular Pharmacology June 2008, 73 (6) 1761-1768; DOI: https://doi.org/10.1124/mol.108.045328
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  Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Is Important in Induction of Drug-Specific T-Cell Responses in Vivo

  Linling Cheng, Benjamin J. Stewart, Qiang You, Dennis R. Petersen, Joseph A. Ware, Joseph R. Piccotti, Thomas T. Kawabata and Cynthia Ju

  Molecular Pharmacology June 2008, 73 (6) 1769-1775; DOI: https://doi.org/10.1124/mol.107.043273
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  Potent, Selective and Cell Penetrant Inhibitors of SF-1 by Functional Ultra-High-Throughput Screening

  Franck Madoux, Xiaolin Li, Peter Chase, Gina Zastrow, Michael D. Cameron, Juliana J. Conkright, Patrick R. Griffin, Scott Thacher and Peter Hodder

  Molecular Pharmacology June 2008, 73 (6) 1776-1784; DOI: https://doi.org/10.1124/mol.108.045963
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  Kavalactones Protect Neural Cells against Amyloid β Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation

  Christoph J. Wruck, Mario E. Götz, Thomas Herdegen, Deike Varoga, Lars-Ove Brandenburg and Thomas Pufe

  Molecular Pharmacology June 2008, 73 (6) 1785-1795; DOI: https://doi.org/10.1124/mol.107.042499
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  Partial Deletion of the Nicotinic Cholinergic Receptor α4 or β2 Subunit Genes Changes the Acetylcholine Sensitivity of Receptor-Mediated ⁸⁶Rb⁺ Efflux in Cortex and Thalamus and Alters Relative Expression of α4 and β2 Subunits

  Cecilia Gotti, Milena Moretti, Natalie M. Meinerz, Francesco Clementi, Annalisa Gaimarri, Allan C. Collins and Michael J. Marks

  Molecular Pharmacology June 2008, 73 (6) 1796-1807; DOI: https://doi.org/10.1124/mol.108.045203
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  Amiloride Derivatives and a Nonpeptidic Antagonist Bind at Two Distinct Allosteric Sites in the Human Gonadotropin-Releasing Hormone Receptor

  Laura H. Heitman, Kai Ye, Julia Oosterom and Adriaan P. IJzerman

  Molecular Pharmacology June 2008, 73 (6) 1808-1815; DOI: https://doi.org/10.1124/mol.107.043521
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  Activation of Tyrosine Hydroxylase mRNA Translation by cAMP in Midbrain Dopaminergic Neurons

  Xiqun Chen, Lu Xu, Pheona Radcliffe, Baoyong Sun and A. William Tank

  Molecular Pharmacology June 2008, 73 (6) 1816-1828; DOI: https://doi.org/10.1124/mol.107.043968
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  ATP Modulates Poly(ADP-Ribose) Polymerase-1-Facilitated Topoisomerase I-Linked DNA Religation in the Presence of Camptothecin

  Shin-Young Park, Chung-Hang Leung and Yung-Chi Cheng

  Molecular Pharmacology June 2008, 73 (6) 1829-1837; DOI: https://doi.org/10.1124/mol.107.044438
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  Sazetidine-A Is a Potent and Selective Agonist at Native and Recombinant α4β2 Nicotinic Acetylcholine Receptors

  Ruud Zwart, Anna L. Carbone, Mirko Moroni, Isabel Bermudez, Adrian J. Mogg, Elizabeth A. Folly, Lisa M. Broad, Andrew C. Williams, Deyi Zhang, Chunjin Ding, Beverly A. Heinz and Emanuele Sher

  Molecular Pharmacology June 2008, 73 (6) 1838-1843; DOI: https://doi.org/10.1124/mol.108.045104
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  Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse

  Nadine Dragin, Zhanquan Shi, Rajat Madan, Christopher L. Karp, Maureen A. Sartor, Chi Chen, Frank J. Gonzalez and Daniel W. Nebert

  Molecular Pharmacology June 2008, 73 (6) 1844-1856; DOI: https://doi.org/10.1124/mol.108.045658
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  In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

  Nathalie Méthot, Daniel Guay, Joel Rubin, Diane Ethier, Karen Ortega, Simon Wong, Denis Normandin, Christian Beaulieu, T. Jagadeeswar Reddy, Denis Riendeau and M. David Percival

  Molecular Pharmacology June 2008, 73 (6) 1857-1865; DOI: https://doi.org/10.1124/mol.108.045682