Abstract
T-type calcium channels are important for a variety of physiological processes such as brain and heart function. Proper regulation of these channels by second messengers is fundamental; however, our knowledge of the molecular pathways that regulate T-type calcium channels is limited in comparison with other voltage-dependent calcium channels. In this issue of Molecular Pharmacology, Tao et al. (p. 1596) demonstrate that Cav3.2 is regulated by activation of the corticotropin-releasing factor receptor 1 in a Gβγ-dependent manner.
Footnotes
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Please see the related article on page 1596.
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ABBREVIATIONS: CRFR, corticotropin-releasing factor receptor.
- Received March 4, 2008.
- Accepted March 7, 2008.
- The American Society for Pharmacology and Experimental Therapeutics
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