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Research ArticleArticle

In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

Nathalie Méthot, Daniel Guay, Joel Rubin, Diane Ethier, Karen Ortega, Simon Wong, Denis Normandin, Christian Beaulieu, T. Jagadeeswar Reddy, Denis Riendeau and M. David Percival
Molecular Pharmacology June 2008, 73 (6) 1857-1865; DOI: https://doi.org/10.1124/mol.108.045682
Nathalie Méthot
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Daniel Guay
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Joel Rubin
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Diane Ethier
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Karen Ortega
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Simon Wong
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Denis Normandin
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Christian Beaulieu
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T. Jagadeeswar Reddy
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Denis Riendeau
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M. David Percival
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Article Information

vol. 73 no. 6 1857-1865
DOI 
https://doi.org/10.1124/mol.108.045682
PubMed 
18326050

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received January 25, 2008
  • Accepted February 15, 2008
  • Published online May 20, 2008.

Article Versions

  • Earlier version (March 6, 2008 - 09:33).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nathalie Méthot,
  2. Daniel Guay,
  3. Joel Rubin,
  4. Diane Ethier,
  5. Karen Ortega,
  6. Simon Wong,
  7. Denis Normandin,
  8. Christian Beaulieu,
  9. T. Jagadeeswar Reddy,
  10. Denis Riendeau and
  11. M. David Percival
  1. Departments of Biochemistry and Molecular Biology (N.M., J.R., D.E., D.R., M.P.), Medicinal Chemistry (D.G., C.B., T.R.), and Comparative Medicine (K.O., S.W., D.N.), Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
  1. Address correspondence to:
    M. David Percival, Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, Quebec, Canada. H9R 4P8. E-mail: dave_percival{at}merck.com
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Molecular Pharmacology: 73 (6)
Molecular Pharmacology
Vol. 73, Issue 6
1 Jun 2008
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Research ArticleArticle

In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

Nathalie Méthot, Daniel Guay, Joel Rubin, Diane Ethier, Karen Ortega, Simon Wong, Denis Normandin, Christian Beaulieu, T. Jagadeeswar Reddy, Denis Riendeau and M. David Percival
Molecular Pharmacology June 1, 2008, 73 (6) 1857-1865; DOI: https://doi.org/10.1124/mol.108.045682

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Research ArticleArticle

In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

Nathalie Méthot, Daniel Guay, Joel Rubin, Diane Ethier, Karen Ortega, Simon Wong, Denis Normandin, Christian Beaulieu, T. Jagadeeswar Reddy, Denis Riendeau and M. David Percival
Molecular Pharmacology June 1, 2008, 73 (6) 1857-1865; DOI: https://doi.org/10.1124/mol.108.045682
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