Table of Contents

Articles

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  Identification of Regions Required for Apical Membrane Localization of Human Multidrug Resistance Protein 2

  Paul E. Bandler, Christopher J. Westlake, Caroline E. Grant, Susan P. C. Cole and Roger G. Deeley

  Molecular Pharmacology July 2008, 74 (1) 9-19; DOI: https://doi.org/10.1124/mol.108.045674
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  Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells

  Venkatesh L. Hegde, Shweta Hegde, Benjamin F. Cravatt, Lorne J. Hofseth, Mitzi Nagarkatti and Prakash S. Nagarkatti

  Molecular Pharmacology July 2008, 74 (1) 20-33; DOI: https://doi.org/10.1124/mol.108.047035
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  Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L

  Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing, Heather J. Grieser, Elizabeth R. Sharlow, Andrew D. Napper, Donna M. Huryn, Barry S. Cooperman, Amos B. Smith and Scott L. Diamond

  Molecular Pharmacology July 2008, 74 (1) 34-41; DOI: https://doi.org/10.1124/mol.108.046219
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  Niemann-Pick C1-Like 1 Mediates α-Tocopherol Transport

  Kazuya Narushima, Tappei Takada, Yoshihide Yamanashi and Hiroshi Suzuki

  Molecular Pharmacology July 2008, 74 (1) 42-49; DOI: https://doi.org/10.1124/mol.107.043034
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  Molecular Determinants for the Activating/Blocking Actions of the 2H-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle K_ATP Channels

  Domenico Tricarico, Antonietta Mele, Giulia Maria Camerino, Antonio Laghezza, Giuseppe Carbonara, Giuseppe Fracchiolla, Paolo Tortorella, Fulvio Loiodice and Diana Conte Camerino

  Molecular Pharmacology July 2008, 74 (1) 50-58; DOI: https://doi.org/10.1124/mol.108.046615
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  Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization

  Chiara Fiorentini, Chiara Busi, Emanuela Gorruso, Cecilia Gotti, PierFranco Spano and Cristina Missale

  Molecular Pharmacology July 2008, 74 (1) 59-69; DOI: https://doi.org/10.1124/mol.107.043885
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  Baicalein Induces Functional Hypoxia-Inducible Factor-1α and Angiogenesis

  Hyunju Cho, Ho-Youl Lee, Dae-Ro Ahn, Sang Yoon Kim, Sunyun Kim, Keun Byeol Lee, You Mie Lee, Hyunsung Park and Eun Gyeong Yang

  Molecular Pharmacology July 2008, 74 (1) 70-81; DOI: https://doi.org/10.1124/mol.107.040162
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  Carmustine-Resistant Cancer Cells Are Sensitized to Temozolomide As A Result of Enhanced Mismatch Repair during the Development of Carmustine Resistance

  Takahiro Yamauchi, Masami Ogawa and Takanori Ueda

  Molecular Pharmacology July 2008, 74 (1) 82-91; DOI: https://doi.org/10.1124/mol.107.041988
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  Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and Other Tenofovir Phosphonoamidate Prodrugs by Human Proteases

  Gabriel Birkus, Nilima Kutty, Gong-Xin He, Andrew Mulato, William Lee, Martin McDermott and Tomas Cihlar

  Molecular Pharmacology July 2008, 74 (1) 92-100; DOI: https://doi.org/10.1124/mol.108.045526
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  RNA Interference-Mediated Knockdown of Dynamin 2 Reduces Endocannabinoid Uptake into Neuronal dCAD Cells

  Matthew J. McFarland, Tamera K. Bardell, Marla L. Yates, Ekaterina A. Placzek and Eric L. Barker

  Molecular Pharmacology July 2008, 74 (1) 101-108; DOI: https://doi.org/10.1124/mol.108.044834
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  Histone Deacetylase Inhibitors Exert Time-Dependent Effects on Nuclear Factor-κB but Consistently Suppress the Expression of Proinflammatory Genes in Human Myometrial Cells

  Tamsin M. Lindström, Aarthi R. Mohan, Mark R. Johnson and Phillip R. Bennett

  Molecular Pharmacology July 2008, 74 (1) 109-121; DOI: https://doi.org/10.1124/mol.107.042838
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  Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

  Adam L. VanWert, Chutima Srimaroeng and Douglas H. Sweet

  Molecular Pharmacology July 2008, 74 (1) 122-131; DOI: https://doi.org/10.1124/mol.107.042853
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  Roles of Accessory Subunits in α4β2^* Nicotinic Receptors

  Alexandre Kuryatov, Jennifer Onksen and Jon Lindstrom

  Molecular Pharmacology July 2008, 74 (1) 132-143; DOI: https://doi.org/10.1124/mol.108.046789
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  Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27^Kip1/Cyclin E Expression

  N. Ferri, A. Granata, C. Pirola, F. Torti, P. J. Pfister, R. Dorent and A. Corsini

  Molecular Pharmacology July 2008, 74 (1) 144-153; DOI: https://doi.org/10.1124/mol.108.046045
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  Molecular Mechanisms of Topical Anti-Inflammatory Effects of Lipoxin A₄ in Endotoxin-Induced Uveitis

  Rodrigo Medeiros, Gustavo Büchele Rodrigues, Cláudia Pinto Figueiredo, Eduardo Büchele Rodrigues, Astor Grumman, Octavio Menezes-de-Lima, Giselle Fazzioni Passos and João Batista Calixto

  Molecular Pharmacology July 2008, 74 (1) 154-161; DOI: https://doi.org/10.1124/mol.108.046870
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  Conformational Rearrangements and Signaling Cascades Involved in Ligand-Biased Mitogen-Activated Protein Kinase Signaling through the β1-Adrenergic Receptor

  Ségolène Galandrin, Geneviève Oligny-Longpré, Hélène Bonin, Koji Ogawa, Céline Galés and Michel Bouvier

  Molecular Pharmacology July 2008, 74 (1) 162-172; DOI: https://doi.org/10.1124/mol.107.043893
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  AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition

  Simona Caporali, Lauretta Levati, Giuseppe Starace, Gianluca Ragone, Enzo Bonmassar, Ester Alvino and Stefania D'Atri

  Molecular Pharmacology July 2008, 74 (1) 173-183; DOI: https://doi.org/10.1124/mol.107.044743
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  Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets

  Benny J. Evison, Francis Chiu, Gabriella Pezzoni, Don R. Phillips and Suzanne M. Cutts

  Molecular Pharmacology July 2008, 74 (1) 184-194; DOI: https://doi.org/10.1124/mol.108.045625
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  Arrestin Binds to Different Phosphorylated Regions of the Thyrotropin-Releasing Hormone Receptor with Distinct Functional Consequences

  Brian W. Jones and Patricia M. Hinkle

  Molecular Pharmacology July 2008, 74 (1) 195-202; DOI: https://doi.org/10.1124/mol.108.045948
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  Individually Monitoring Ligand-Induced Changes in the Structure of the GABA_A Receptor at Benzodiazepine Binding Site and Non-Binding-Site Interfaces

  L. M. Sharkey and C. Czajkowski

  Molecular Pharmacology July 2008, 74 (1) 203-212; DOI: https://doi.org/10.1124/mol.108.044891
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  N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons

  Neta Rimmerman, Heather B. Bradshaw, H. Velocity Hughes, Jay Shih-Chieh Chen, Sherry Shu-Jung Hu, Douglas McHugh, Eivind Vefring, Jan A. Jahnsen, Eric L. Thompson, Kim Masuda, Benjamin F. Cravatt, Sumner Burstein, Michael R. Vasko, Anne L. Prieto, David K. O'Dell and J. Michael Walker

  Molecular Pharmacology July 2008, 74 (1) 213-224; DOI: https://doi.org/10.1124/mol.108.045997
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  Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class

  C. K. Lim, D. S. Kalinowski and D. R. Richardson

  Molecular Pharmacology July 2008, 74 (1) 225-235; DOI: https://doi.org/10.1124/mol.108.046847
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  Nitric Oxide Donor, (±)-S-Nitroso-N-acetylpenicillamine, Stabilizes Transactive Hypoxia-Inducible Factor-1α by Inhibiting von Hippel-Lindau Recruitment and Asparagine Hydroxylation

  Young-Kwon Park, Dae-Ro Ahn, Myoungsuk Oh, Taekyoung Lee, Eun Gyeong Yang, Miwon Son and Hyunsung Park

  Molecular Pharmacology July 2008, 74 (1) 236-245; DOI: https://doi.org/10.1124/mol.108.045278
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  Disruption of Signaling through SEK1 and MKK7 Yields Differential Responses in Hypoxic Colon Cancer Cells Treated with Oxaliplatin

  Irina A. Vasilevskaya, Muthu Selvakumaran and Peter J. O'Dwyer

  Molecular Pharmacology July 2008, 74 (1) 246-254; DOI: https://doi.org/10.1124/mol.107.044644
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  Roles of Cytosolic Phospholipase A2 and Src Kinase in the Early Action of 2,3,7,8-Tetrachlorodibenzo-p-dioxin through a Nongenomic Pathway in MCF10A Cells

  Bin Dong and Fumio Matsumura

  Molecular Pharmacology July 2008, 74 (1) 255-263; DOI: https://doi.org/10.1124/mol.107.044669
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  Characterization of mENT1Δ11, a Novel Alternative Splice Variant of the Mouse Equilibrative Nucleoside Transporter 1

  Kevin R. Robillard, Derek B.J. Bone, Jamie S. Park and James R. Hammond

  Molecular Pharmacology July 2008, 74 (1) 264-273; DOI: https://doi.org/10.1124/mol.107.041871
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  Inhibition of Nod2 Signaling and Target Gene Expression by Curcumin

  Shurong Huang, Ling Zhao, Kihoon Kim, Dong Seok Lee and Daniel H. Hwang

  Molecular Pharmacology July 2008, 74 (1) 274-281; DOI: https://doi.org/10.1124/mol.108.046169
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  (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors

  Marie-Claude Lauzier, Geneviève A. Robitaille, Denise A. Chan, Amato J. Giaccia and Darren E. Richard

  Molecular Pharmacology July 2008, 74 (1) 282-288; DOI: https://doi.org/10.1124/mol.108.045690
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  Selective Killing of Smad4-Negative Tumor Cells via a Designed Repressor Strategy

  Vidula Dixit and Rudy L. Juliano

  Molecular Pharmacology July 2008, 74 (1) 289-297; DOI: https://doi.org/10.1124/mol.108.046953
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  α_vβ₃ Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species

  Anamaria Brozović, Dragomira Majhen, Vibor Roje, Nevenka Mikac, Sanjica Jakopec, Gerhard Fritz, Maja Osmak and Andreja Ambriović-Ristov

  Molecular Pharmacology July 2008, 74 (1) 298-306; DOI: https://doi.org/10.1124/mol.107.043836