Molecular Pharmacology: 74 (2)

August 01, 2008; Volume 74,Issue 2

Perspectives

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Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity
Raymond Evers and Xiao-Yan Chu

Molecular Pharmacology August 2008, 74 (2) 309-311; DOI: https://doi.org/10.1124/mol.108.048991
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Rich Tapestry of G Protein-Coupled Receptor Signaling and Regulatory Mechanisms
Vsevolod V. Gurevich and Eugenia V. Gurevich

Molecular Pharmacology August 2008, 74 (2) 312-316; DOI: https://doi.org/10.1124/mol.108.049015
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Protein-Protein Interactions and Dopamine D₂ Receptor Signaling: A Calcium Connection
Gregg D. Stanwood

Molecular Pharmacology August 2008, 74 (2) 317-319; DOI: https://doi.org/10.1124/mol.108.049098

Accelerated Communications

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Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin
Hani Zaher, Henriette E. Meyer zu Schwabedissen, Rommel G. Tirona, Melissa L. Cox, Leslie A. Obert, Nidhi Agrawal, Joe Palandra, Jeffrey L. Stock, Richard B. Kim and Joseph A. Ware

Molecular Pharmacology August 2008, 74 (2) 320-329; DOI: https://doi.org/10.1124/mol.108.046458
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Simian Immunodeficiency Virus Is Susceptible to Inhibition by Carbohydrate-Binding Agents in a Manner Similar to That of HIV: Implications for Further Preclinical Drug Development
Katrien O. François, Joeri Auwerx, Dominique Schols and Jan Balzarini

Molecular Pharmacology August 2008, 74 (2) 330-337; DOI: https://doi.org/10.1124/mol.108.047621

Articles

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M₃ Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms
Jiansong Luo, John M. Busillo and Jeffrey L. Benovic

Molecular Pharmacology August 2008, 74 (2) 338-347; DOI: https://doi.org/10.1124/mol.107.044750
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Presynaptic α7- and β2-Containing Nicotinic Acetylcholine Receptors Modulate Excitatory Amino Acid Release from Rat Prefrontal Cortex Nerve Terminals via Distinct Cellular Mechanisms
Jane A. Dickinson, James N. C. Kew and Susan Wonnacott

Molecular Pharmacology August 2008, 74 (2) 348-359; DOI: https://doi.org/10.1124/mol.108.046623
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Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-d-aspartate Receptors to Calpain Cleavage in Cortical Neurons
Eunice Y. Yuen, Yi Ren and Zhen Yan

Molecular Pharmacology August 2008, 74 (2) 360-370; DOI: https://doi.org/10.1124/mol.108.046813
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Novel Interaction of the Dopamine D₂ Receptor and the Ca²⁺ Binding Protein S100B: Role in D₂ Receptor Function
Yong Liu, David C. Buck and Kim A. Neve

Molecular Pharmacology August 2008, 74 (2) 371-378; DOI: https://doi.org/10.1124/mol.108.044925
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Human Nocturnal Frontal Lobe Epilepsy: Pharmocogenomic Profiles of Pathogenic Nicotinic Acetylcholine Receptor β-Subunit Mutations outside the Ion Channel Pore
Jean-Charles Hoda, Wenli Gu, Marc Friedli, Hilary A. Phillips, Sonia Bertrand, Stylianos E. Antonarakis, David Goudie, Richard Roberts, Ingrid E. Scheffer, Carla Marini, Jayesh Patel, Samuel F. Berkovic, John C. Mulley, Ortrud K. Steinlein and Daniel Bertrand

Molecular Pharmacology August 2008, 74 (2) 379-391; DOI: https://doi.org/10.1124/mol.107.044545
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Identification of Novel Formyl Peptide Receptor-Like 1 Agonists That Induce Macrophage Tumor Necrosis Factor α Production
Igor A. Schepetkin, Liliya N. Kirpotina, Jun Tian, Andrei I. Khlebnikov, Richard D. Ye and Mark T. Quinn

Molecular Pharmacology August 2008, 74 (2) 392-402; DOI: https://doi.org/10.1124/mol.108.046946
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Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States
Eric S. Muise, Barbara Azzolina, David W. Kuo, Mohamed El-Sherbeini, Yejun Tan, Xiling Yuan, James Mu, John R. Thompson, Joel P. Berger and Kenny K. Wong

Molecular Pharmacology August 2008, 74 (2) 403-412; DOI: https://doi.org/10.1124/mol.108.044826
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Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding
Maoqing Dong, Polo C.-H. Lam, Delia I. Pinon, Patrick M. Sexton, Ruben Abagyan and Laurence J. Miller

Molecular Pharmacology August 2008, 74 (2) 413-422; DOI: https://doi.org/10.1124/mol.108.047209
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Enhancing Drug Accumulation in Saccharomyces cerevisiae by Repression of Pleiotropic Drug Resistance Genes with Chimeric Transcription Repressors
Alexander Stepanov, Karin C. Nitiss, Geoffrey Neale and John L. Nitiss

Molecular Pharmacology August 2008, 74 (2) 423-431; DOI: https://doi.org/10.1124/mol.107.044651
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Protein Kinase C Enhances Tight Junction Barrier Function of Human Nasal Epithelial Cells in Primary Culture by Transcriptional Regulation
Jun-ichi Koizumi, Takashi Kojima, Noriko Ogasawara, Ryuta Kamekura, Makoto Kurose, Mitsuru Go, Atsushi Harimaya, Masaki Murata, Makoto Osanai, Hideki Chiba, Tetsuo Himi and Norimasa Sawada

Molecular Pharmacology August 2008, 74 (2) 432-442; DOI: https://doi.org/10.1124/mol.107.043711
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The Peripheral Benzodiazepine Receptor Ligand 1-(2-Chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide Is a Novel Antagonist of Human Constitutive Androstane Receptor
Linhao Li, Tao Chen, Joseph D. Stanton, Tatsuya Sueyoshi, Masahiko Negishi and Hongbing Wang

Molecular Pharmacology August 2008, 74 (2) 443-453; DOI: https://doi.org/10.1124/mol.108.046656
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The NR1 M3 Domain Mediates Allosteric Coupling in the N-Methyl-D-aspartate Receptor
Marie L. Blanke and Antonius M. J. VanDongen

Molecular Pharmacology August 2008, 74 (2) 454-465; DOI: https://doi.org/10.1124/mol.107.044115
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Morantel Allosterically Enhances Channel Gating of Neuronal Nicotinic Acetylcholine α3β2 Receptors
Tse-Yu Wu, Caleb M. Smith, Steven M. Sine and Mark M. Levandoski

Molecular Pharmacology August 2008, 74 (2) 466-475; DOI: https://doi.org/10.1124/mol.107.044388
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Activation of Nuclear Factor-κB Pathway by Simvastatin and RhoA Silencing Increases Doxorubicin Cytotoxicity in Human Colon Cancer HT29 Cells
Chiara Riganti, Sophie Doublier, Costanzo Costamagna, Elisabetta Aldieri, Gianpiero Pescarmona, Dario Ghigo and Amalia Bosia

Molecular Pharmacology August 2008, 74 (2) 476-484; DOI: https://doi.org/10.1124/mol.108.045286
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Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events
Mieke Gouwy, Sofie Struyf, Samuel Noppen, Evemie Schutyser, Jean-Yves Springael, Marc Parmentier, Paul Proost and Jo Van Damme

Molecular Pharmacology August 2008, 74 (2) 485-495; DOI: https://doi.org/10.1124/mol.108.045146
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T-Cell Receptor/CD28-Mediated Activation of Human T Lymphocytes Induces Expression of Functional μ-Opioid Receptors
Christine Börner, Jürgen Kraus, Andrea Bedini, Burkhart Schraven and Volker Höllt

Molecular Pharmacology August 2008, 74 (2) 496-504; DOI: https://doi.org/10.1124/mol.108.046029
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Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
Ram N. Trivedi, Xiao-hong Wang, Elena Jelezcova, Eva M. Goellner, Jiang-bo Tang and Robert W. Sobol

Molecular Pharmacology August 2008, 74 (2) 505-516; DOI: https://doi.org/10.1124/mol.108.045112
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Transcriptional Repression of O⁶-Methylguanine DNA Methyltransferase Gene Rendering Cells Hypersensitive to N,N′-Bis(2-chloroethyl)-N-nitrosurea in Camptothecin-Resistant Cells
Li-Chen Ma, Ching-Chuan Kuo, Jin-Fen Liu, Li-Tzong Chen and Jang-Yang Chang

Molecular Pharmacology August 2008, 74 (2) 517-526; DOI: https://doi.org/10.1124/mol.107.043620
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Cellular Energetic Status Supervises the Synthesis of Bis-Diphosphoinositol Tetrakisphosphate Independently of AMP-Activated Protein Kinase
Kuicheon Choi, Elahe Mollapour, Jae H. Choi and Stephen B. Shears

Molecular Pharmacology August 2008, 74 (2) 527-536; DOI: https://doi.org/10.1124/mol.107.044628

Errata

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Correction to “Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21^WAF1/CIP1”
Molecular Pharmacology August 2008, 74 (2) 537; DOI: https://doi.org/10.1124/mol.74.2.537
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Correction to “A Functional Steroid-Binding Element in an ATP-Binding Cassette Multidrug Transporter”
Molecular Pharmacology August 2008, 74 (2) 538; DOI: https://doi.org/10.1124/mol.74.2.538
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Correction to “Stretch Induction of Cyclooxygenase-2 Expression in Human Urothelial Cells Is Calcium- and Protein Kinase Cζ-Dependent”
Molecular Pharmacology August 2008, 74 (2) 539; DOI: https://doi.org/10.1124/mol.74.2.539
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Correction to “Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8”
Molecular Pharmacology August 2008, 74 (2) 539; DOI: https://doi.org/10.1124/mol.74.2.539-a

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