Table of Contents

Articles

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  Mutational Analysis of the Conserved Asp^2.50 and ERY Motif Reveals Signaling Bias of the Urotensin II Receptor

  Christophe D. Proulx, Brian J. Holleran, Antony A. Boucard, Emanuel Escher, Gaétan Guillemette and Richard Leduc

  Molecular Pharmacology September 2008, 74 (3) 552-561; DOI: https://doi.org/10.1124/mol.108.045054
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  Different Internalization Properties of the α1a- and α1b-Adrenergic Receptor Subtypes: The Potential Role of Receptor Interaction with β-Arrestins and AP50

  Laura Stanasila, Liliane Abuin, Julien Dey and Susanna Cotecchia

  Molecular Pharmacology September 2008, 74 (3) 562-573; DOI: https://doi.org/10.1124/mol.107.043422
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  Effects of Active and Inactive Phospholipase D2 on Signal Transduction, Adhesion, Migration, Invasion, and Metastasis in EL4 Lymphoma Cells

  Stewart M. Knoepp, Manpreet S. Chahal, Yuhuan Xie, Zhihong Zhang, Daniel J. Brauner, Mark A. Hallman, Stephanie A. Robinson, Shujie Han, Masaki Imai, Stephen Tomlinson and Kathryn E. Meier

  Molecular Pharmacology September 2008, 74 (3) 574-584; DOI: https://doi.org/10.1124/mol.107.040105
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  Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor

  Larry S. Barak, Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron and Raul R. Gainetdinov

  Molecular Pharmacology September 2008, 74 (3) 585-594; DOI: https://doi.org/10.1124/mol.108.048884
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  Midazolam Reverses Salicylate-Induced Changes in Brain-Derived Neurotrophic Factor and Arg3.1 Expression: Implications for Tinnitus Perception and Auditory Plasticity

  Rama Panford-Walsh, Wibke Singer, Lukas Rüttiger, Saida Hadjab, Justin Tan, Hyun-Soon Geisler, Ulrike Zimmermann, Iris Köpschall, Karin Rohbock, Anna Vieljans, Elmar Oestreicher and Marlies Knipper

  Molecular Pharmacology September 2008, 74 (3) 595-604; DOI: https://doi.org/10.1124/mol.108.046375
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  Ligand-Receptor Interactions at the Parathyroid Hormone Receptors: Subtype Binding Selectivity Is Mediated via an Interaction between Residue 23 on the Ligand and Residue 41 on the Receptor

  Rosalind Mann, Mark J. Wigglesworth and Dan Donnelly

  Molecular Pharmacology September 2008, 74 (3) 605-613; DOI: https://doi.org/10.1124/mol.108.048017
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  Mutations of the GABA-A Receptor α1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids

  Gustav Akk, Ping Li, John Bracamontes, David E. Reichert, Douglas F. Covey and Joe Henry Steinbach

  Molecular Pharmacology September 2008, 74 (3) 614-627; DOI: https://doi.org/10.1124/mol.108.048520
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  Ethanol Modulates BK_Ca Channels by Acting as an Adjuvant of Calcium

  Jianxi Liu, Thirumalini Vaithianathan, Kandiah Manivannan, Abby Parrill and Alejandro M. Dopico

  Molecular Pharmacology September 2008, 74 (3) 628-640; DOI: https://doi.org/10.1124/mol.108.048694
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  A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State

  Lisa Mathiasen, Daniel M. Dupont, Anni Christensen, Grant E. Blouse, Jan K. Jensen, Ann Gils, Paul J. Declerck, Troels Wind and Peter A. Andreasen

  Molecular Pharmacology September 2008, 74 (3) 641-653; DOI: https://doi.org/10.1124/mol.108.046417
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  Inhibition of IκB Kinase-Nuclear Factor-κB Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin

  Andrea L. Kasinski, Yuhong Du, Shala L. Thomas, Jing Zhao, Shi-Yong Sun, Fadlo R. Khuri, Cun-Yu Wang, Mamoru Shoji, Aiming Sun, James P. Snyder, Dennis Liotta and Haian Fu

  Molecular Pharmacology September 2008, 74 (3) 654-661; DOI: https://doi.org/10.1124/mol.108.046201
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  Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists

  Sean Ekins, Vladyslav Kholodovych, Ni Ai, Michael Sinz, Joseph Gal, Lajos Gera, William J. Welsh, Kenneth Bachmann and Sridhar Mani

  Molecular Pharmacology September 2008, 74 (3) 662-672; DOI: https://doi.org/10.1124/mol.108.049437
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  Caffeine Stimulates Cytochrome Oxidase Expression and Activity in the Striatum in a Sexually Dimorphic Manner

  Frederick S. Jones, Jie Jing, Anthony H. Stonehouse, Anthony Stevens and Gerald M. Edelman

  Molecular Pharmacology September 2008, 74 (3) 673-684; DOI: https://doi.org/10.1124/mol.108.046888
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  Activation of the A₃ Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils

  Dharini van der Hoeven, Tina C. Wan and John A. Auchampach

  Molecular Pharmacology September 2008, 74 (3) 685-696; DOI: https://doi.org/10.1124/mol.108.048066
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  Elevated Glutathione Levels Confer Cellular Sensitization to Cisplatin Toxicity by Up-Regulation of Copper Transporter hCtr1

  Helen H. W. Chen, Im-Sook Song, Anwar Hossain, Min-Koo Choi, Yoshiaki Yamane, Zheng D. Liang, Jia Lu, Lily Y.-H. Wu, Zahid H. Siddik, Leo W. J. Klomp, Niramol Savaraj and Macus Tien Kuo

  Molecular Pharmacology September 2008, 74 (3) 697-704; DOI: https://doi.org/10.1124/mol.108.047969
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  Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells

  Im-Sook Song, Helen H. W. Chen, Isamu Aiba, Anwar Hossain, Zheng D. Liang, Leo W. J. Klomp and Macus Tien Kuo

  Molecular Pharmacology September 2008, 74 (3) 705-713; DOI: https://doi.org/10.1124/mol.108.046771
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  Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course

  Huixia Zhang, Xiaohui Wu, Honggang Wang, Andrei M. Mikheev, Qingcheng Mao and Jashvant D. Unadkat

  Molecular Pharmacology September 2008, 74 (3) 714-723; DOI: https://doi.org/10.1124/mol.107.043851
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  Overcoming S-Phase Checkpoint-Mediated Resistance: Sequence-Dependent Synergy of Gemcitabine and 7-Ethyl-10-hydroxycamptothecin (SN-38) in Human Carcinoma Cell Lines

  Marina Gálvez-Peralta, Nga T. Dai, David A. Loegering, Karen S. Flatten, Stephanie L. Safgren, Jill M. Wagner, Matthew M. Ames, Larry M. Karnitz and Scott H. Kaufmann

  Molecular Pharmacology September 2008, 74 (3) 724-735; DOI: https://doi.org/10.1124/mol.108.047787
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  Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by ATP-Sensitive K⁺ Channel Openers

  Adebowale Adebiyi, Elizabeth M. McNally and Jonathan H. Jaggar

  Molecular Pharmacology September 2008, 74 (3) 736-743; DOI: https://doi.org/10.1124/mol.108.048165
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  Novel Polymorphic Human UDP-glucuronosyltransferase 2A3: Cloning, Functional Characterization of Enzyme Variants, Comparative Tissue Expression, and Gene Induction

  Michael H. Court, Suwagmani Hazarika, Soundararajan Krishnaswamy, Moshe Finel and J. Andrew Williams

  Molecular Pharmacology September 2008, 74 (3) 744-754; DOI: https://doi.org/10.1124/mol.108.045500
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  Aging-Resistant Organophosphate Bioscavenger Based on Polyethylene Glycol-Conjugated F338A Human Acetylcholinesterase

  Ohad Mazor, Ofer Cohen, Chanoch Kronman, Lily Raveh, Dana Stein, Arie Ordentlich and Avigdor Shafferman

  Molecular Pharmacology September 2008, 74 (3) 755-763; DOI: https://doi.org/10.1124/mol.108.047449
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  Activation and Block of the Adult Muscle-Type Nicotinic Receptor by Physostigmine: Single-Channel Studies

  Julius Militante, Bei-Wen Ma, Gustav Akk and Joe Henry Steinbach

  Molecular Pharmacology September 2008, 74 (3) 764-776; DOI: https://doi.org/10.1124/mol.108.047134
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  Knockout Mice Reveal a Role for P2Y₆ Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells

  Isabelle Bar, Pieter-Jan Guns, Jessica Metallo, Dorothée Cammarata, Françoise Wilkin, Jean-Marie Boeynams, Hidde Bult and Bernard Robaye

  Molecular Pharmacology September 2008, 74 (3) 777-784; DOI: https://doi.org/10.1124/mol.108.046904
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  Direct Modulation of P2X₁ Receptor-Channels by the Lipid Phosphatidylinositol 4,5-Bisphosphate

  Louis-Philippe Bernier, Ariel R. Ase, Xinkang Tong, Edith Hamel, Dominique Blais, Qi Zhao, Diomedes E. Logothetis and Philippe Séguéla

  Molecular Pharmacology September 2008, 74 (3) 785-792; DOI: https://doi.org/10.1124/mol.108.047019
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  RETRACTION: Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small-Cell Lung Cancer Cells with Epidermal Growth Factor Receptor^L858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of BAX and BAK

  Yi-He Ling, Ruoping Lin and Roman Perez-Soler

  Molecular Pharmacology September 2008, 74 (3) 793-806; DOI: https://doi.org/10.1124/mol.107.044396
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  Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation

  Aditi Pandya Martin, Anna Miller, Luni Emad, Mohammed Rahmani, Teneille Walker, Clint Mitchell, Michael P. Hagan, Margaret A. Park, Adly Yacoub, Paul B. Fisher, Steven Grant and Paul Dent

  Molecular Pharmacology September 2008, 74 (3) 807-822; DOI: https://doi.org/10.1124/mol.108.047365
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  Elevated GSH Level Increases Cadmium Resistance through Down-Regulation of Sp1-Dependent Expression of the Cadmium Transporter ZIP8

  Isamu Aiba, Anwar Hossain and Macus Tien Kuo

  Molecular Pharmacology September 2008, 74 (3) 823-833; DOI: https://doi.org/10.1124/mol.108.046862
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  Binding of Orthosteric Ligands to the Allosteric Site of the M₂ Muscarinic Cholinergic Receptor

  Dar′ya S. Redka, Luca F. Pisterzi and James W. Wells

  Molecular Pharmacology September 2008, 74 (3) 834-843; DOI: https://doi.org/10.1124/mol.108.048074
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  Long-Term Nicotine Treatment Differentially Regulates Striatal α6α4β2^* and α6(Nonα4)β2^* nAChR Expression and Function

  Xiomara A. Perez, Tanuja Bordia, J. Michael McIntosh, Sharon R. Grady and Maryka Quik

  Molecular Pharmacology September 2008, 74 (3) 844-853; DOI: https://doi.org/10.1124/mol.108.048843
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  The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

  Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas and I. David Goldman

  Molecular Pharmacology September 2008, 74 (3) 854-862; DOI: https://doi.org/10.1124/mol.108.045443
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  MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches

  Sheryl A. Flanagan, Christina M. Krokosky, Sudha Mannava, Mikhail A. Nikiforov and Donna S. Shewach

  Molecular Pharmacology September 2008, 74 (3) 863-871; DOI: https://doi.org/10.1124/mol.107.043349
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  Combinatorial Antileukemic Disruption of Oxidative Homeostasis and Mitochondrial Stability by the Redox Reactive Thalidomide 2-(2,4-Difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and Flavopiridol

  Yun Ge, Jung S. Byun, Paola De Luca, Geraldine Gueron, Idalia M. Yabe, Sara G. Sadiq-Ali, William D. Figg, Jesse Quintero, Cynthia M. Haggerty, Quentin Q. Li, Adriana De Siervi and Kevin Gardner

  Molecular Pharmacology September 2008, 74 (3) 872-883; DOI: https://doi.org/10.1124/mol.107.040808
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  Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia

  Federica Falà, William L. Blalock, Pier Luigi Tazzari, Alessandra Cappellini, Francesca Chiarini, Giovanni Martinelli, Agostino Tafuri, James A. McCubrey, Lucio Cocco and Alberto M. Martelli

  Molecular Pharmacology September 2008, 74 (3) 884-895; DOI: https://doi.org/10.1124/mol.108.047639
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  Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza

  David Marsolais, Bumsuk Hahm, Kurt H. Edelmann, Kevin B. Walsh, Miguel Guerrero, Yasuko Hatta, Yoshihiro Kawaoka, Edward Roberts, Michael B. A. Oldstone and Hugh Rosen

  Molecular Pharmacology September 2008, 74 (3) 896-903; DOI: https://doi.org/10.1124/mol.108.048769
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  Alternative Splicing of the Ca²⁺ Channel β4 Subunit Confers Specificity for Gabapentin Inhibition of Ca_v2.1 Trafficking

  Patrice M. Mich and William A. Horne

  Molecular Pharmacology September 2008, 74 (3) 904-912; DOI: https://doi.org/10.1124/mol.108.045153
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  Nuclear Receptor Coactivator 6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4α

  Sailesh Surapureddi, Ritu Rana, Janardan K. Reddy and Joyce A. Goldstein

  Molecular Pharmacology September 2008, 74 (3) 913-923; DOI: https://doi.org/10.1124/mol.108.048983