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Molecular Pharmacology

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Table of Contents

September 01, 2008; Volume 74,Issue 3

Perspective

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    Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein: De-emphasizing the Geography of Binding
    Terry P. Kenakin
    Molecular Pharmacology September 2008, 74 (3) 541-543; DOI: https://doi.org/10.1124/mol.108.050062

Accelerated Communication

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    Ligand-Dependent Oligomerization of Dopamine D2 and Adenosine A2A Receptors in Living Neuronal Cells
    Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng Hu and Val J. Watts
    Molecular Pharmacology September 2008, 74 (3) 544-551; DOI: https://doi.org/10.1124/mol.108.047472

Articles

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    Mutational Analysis of the Conserved Asp2.50 and ERY Motif Reveals Signaling Bias of the Urotensin II Receptor
    Christophe D. Proulx, Brian J. Holleran, Antony A. Boucard, Emanuel Escher, Gaétan Guillemette and Richard Leduc
    Molecular Pharmacology September 2008, 74 (3) 552-561; DOI: https://doi.org/10.1124/mol.108.045054
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    Different Internalization Properties of the α1a- and α1b-Adrenergic Receptor Subtypes: The Potential Role of Receptor Interaction with β-Arrestins and AP50
    Laura Stanasila, Liliane Abuin, Julien Dey and Susanna Cotecchia
    Molecular Pharmacology September 2008, 74 (3) 562-573; DOI: https://doi.org/10.1124/mol.107.043422
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    Effects of Active and Inactive Phospholipase D2 on Signal Transduction, Adhesion, Migration, Invasion, and Metastasis in EL4 Lymphoma Cells
    Stewart M. Knoepp, Manpreet S. Chahal, Yuhuan Xie, Zhihong Zhang, Daniel J. Brauner, Mark A. Hallman, Stephanie A. Robinson, Shujie Han, Masaki Imai, Stephen Tomlinson and Kathryn E. Meier
    Molecular Pharmacology September 2008, 74 (3) 574-584; DOI: https://doi.org/10.1124/mol.107.040105
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    Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor
    Larry S. Barak, Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron and Raul R. Gainetdinov
    Molecular Pharmacology September 2008, 74 (3) 585-594; DOI: https://doi.org/10.1124/mol.108.048884
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    Midazolam Reverses Salicylate-Induced Changes in Brain-Derived Neurotrophic Factor and Arg3.1 Expression: Implications for Tinnitus Perception and Auditory Plasticity
    Rama Panford-Walsh, Wibke Singer, Lukas Rüttiger, Saida Hadjab, Justin Tan, Hyun-Soon Geisler, Ulrike Zimmermann, Iris Köpschall, Karin Rohbock, Anna Vieljans, Elmar Oestreicher and Marlies Knipper
    Molecular Pharmacology September 2008, 74 (3) 595-604; DOI: https://doi.org/10.1124/mol.108.046375
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    Ligand-Receptor Interactions at the Parathyroid Hormone Receptors: Subtype Binding Selectivity Is Mediated via an Interaction between Residue 23 on the Ligand and Residue 41 on the Receptor
    Rosalind Mann, Mark J. Wigglesworth and Dan Donnelly
    Molecular Pharmacology September 2008, 74 (3) 605-613; DOI: https://doi.org/10.1124/mol.108.048017
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    Mutations of the GABA-A Receptor α1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids
    Gustav Akk, Ping Li, John Bracamontes, David E. Reichert, Douglas F. Covey and Joe Henry Steinbach
    Molecular Pharmacology September 2008, 74 (3) 614-627; DOI: https://doi.org/10.1124/mol.108.048520
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    Ethanol Modulates BKCa Channels by Acting as an Adjuvant of Calcium
    Jianxi Liu, Thirumalini Vaithianathan, Kandiah Manivannan, Abby Parrill and Alejandro M. Dopico
    Molecular Pharmacology September 2008, 74 (3) 628-640; DOI: https://doi.org/10.1124/mol.108.048694
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    A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State
    Lisa Mathiasen, Daniel M. Dupont, Anni Christensen, Grant E. Blouse, Jan K. Jensen, Ann Gils, Paul J. Declerck, Troels Wind and Peter A. Andreasen
    Molecular Pharmacology September 2008, 74 (3) 641-653; DOI: https://doi.org/10.1124/mol.108.046417
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    Inhibition of IκB Kinase-Nuclear Factor-κB Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin
    Andrea L. Kasinski, Yuhong Du, Shala L. Thomas, Jing Zhao, Shi-Yong Sun, Fadlo R. Khuri, Cun-Yu Wang, Mamoru Shoji, Aiming Sun, James P. Snyder, Dennis Liotta and Haian Fu
    Molecular Pharmacology September 2008, 74 (3) 654-661; DOI: https://doi.org/10.1124/mol.108.046201
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    Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
    Sean Ekins, Vladyslav Kholodovych, Ni Ai, Michael Sinz, Joseph Gal, Lajos Gera, William J. Welsh, Kenneth Bachmann and Sridhar Mani
    Molecular Pharmacology September 2008, 74 (3) 662-672; DOI: https://doi.org/10.1124/mol.108.049437
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    Caffeine Stimulates Cytochrome Oxidase Expression and Activity in the Striatum in a Sexually Dimorphic Manner
    Frederick S. Jones, Jie Jing, Anthony H. Stonehouse, Anthony Stevens and Gerald M. Edelman
    Molecular Pharmacology September 2008, 74 (3) 673-684; DOI: https://doi.org/10.1124/mol.108.046888
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    Activation of the A3 Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils
    Dharini van der Hoeven, Tina C. Wan and John A. Auchampach
    Molecular Pharmacology September 2008, 74 (3) 685-696; DOI: https://doi.org/10.1124/mol.108.048066
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    Elevated Glutathione Levels Confer Cellular Sensitization to Cisplatin Toxicity by Up-Regulation of Copper Transporter hCtr1
    Helen H. W. Chen, Im-Sook Song, Anwar Hossain, Min-Koo Choi, Yoshiaki Yamane, Zheng D. Liang, Jia Lu, Lily Y.-H. Wu, Zahid H. Siddik, Leo W. J. Klomp, Niramol Savaraj and Macus Tien Kuo
    Molecular Pharmacology September 2008, 74 (3) 697-704; DOI: https://doi.org/10.1124/mol.108.047969
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    Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells
    Im-Sook Song, Helen H. W. Chen, Isamu Aiba, Anwar Hossain, Zheng D. Liang, Leo W. J. Klomp and Macus Tien Kuo
    Molecular Pharmacology September 2008, 74 (3) 705-713; DOI: https://doi.org/10.1124/mol.108.046771
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    Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course
    Huixia Zhang, Xiaohui Wu, Honggang Wang, Andrei M. Mikheev, Qingcheng Mao and Jashvant D. Unadkat
    Molecular Pharmacology September 2008, 74 (3) 714-723; DOI: https://doi.org/10.1124/mol.107.043851
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    Overcoming S-Phase Checkpoint-Mediated Resistance: Sequence-Dependent Synergy of Gemcitabine and 7-Ethyl-10-hydroxycamptothecin (SN-38) in Human Carcinoma Cell Lines
    Marina Gálvez-Peralta, Nga T. Dai, David A. Loegering, Karen S. Flatten, Stephanie L. Safgren, Jill M. Wagner, Matthew M. Ames, Larry M. Karnitz and Scott H. Kaufmann
    Molecular Pharmacology September 2008, 74 (3) 724-735; DOI: https://doi.org/10.1124/mol.108.047787
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    Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by ATP-Sensitive K+ Channel Openers
    Adebowale Adebiyi, Elizabeth M. McNally and Jonathan H. Jaggar
    Molecular Pharmacology September 2008, 74 (3) 736-743; DOI: https://doi.org/10.1124/mol.108.048165
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    Novel Polymorphic Human UDP-glucuronosyltransferase 2A3: Cloning, Functional Characterization of Enzyme Variants, Comparative Tissue Expression, and Gene Induction
    Michael H. Court, Suwagmani Hazarika, Soundararajan Krishnaswamy, Moshe Finel and J. Andrew Williams
    Molecular Pharmacology September 2008, 74 (3) 744-754; DOI: https://doi.org/10.1124/mol.108.045500
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    Aging-Resistant Organophosphate Bioscavenger Based on Polyethylene Glycol-Conjugated F338A Human Acetylcholinesterase
    Ohad Mazor, Ofer Cohen, Chanoch Kronman, Lily Raveh, Dana Stein, Arie Ordentlich and Avigdor Shafferman
    Molecular Pharmacology September 2008, 74 (3) 755-763; DOI: https://doi.org/10.1124/mol.108.047449
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    Activation and Block of the Adult Muscle-Type Nicotinic Receptor by Physostigmine: Single-Channel Studies
    Julius Militante, Bei-Wen Ma, Gustav Akk and Joe Henry Steinbach
    Molecular Pharmacology September 2008, 74 (3) 764-776; DOI: https://doi.org/10.1124/mol.108.047134
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    Knockout Mice Reveal a Role for P2Y6 Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells
    Isabelle Bar, Pieter-Jan Guns, Jessica Metallo, Dorothée Cammarata, Françoise Wilkin, Jean-Marie Boeynams, Hidde Bult and Bernard Robaye
    Molecular Pharmacology September 2008, 74 (3) 777-784; DOI: https://doi.org/10.1124/mol.108.046904
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    Direct Modulation of P2X1 Receptor-Channels by the Lipid Phosphatidylinositol 4,5-Bisphosphate
    Louis-Philippe Bernier, Ariel R. Ase, Xinkang Tong, Edith Hamel, Dominique Blais, Qi Zhao, Diomedes E. Logothetis and Philippe Séguéla
    Molecular Pharmacology September 2008, 74 (3) 785-792; DOI: https://doi.org/10.1124/mol.108.047019
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    RETRACTION: Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small-Cell Lung Cancer Cells with Epidermal Growth Factor ReceptorL858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of BAX and BAK
    Yi-He Ling, Ruoping Lin and Roman Perez-Soler
    Molecular Pharmacology September 2008, 74 (3) 793-806; DOI: https://doi.org/10.1124/mol.107.044396
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    Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
    Aditi Pandya Martin, Anna Miller, Luni Emad, Mohammed Rahmani, Teneille Walker, Clint Mitchell, Michael P. Hagan, Margaret A. Park, Adly Yacoub, Paul B. Fisher, Steven Grant and Paul Dent
    Molecular Pharmacology September 2008, 74 (3) 807-822; DOI: https://doi.org/10.1124/mol.108.047365
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    Elevated GSH Level Increases Cadmium Resistance through Down-Regulation of Sp1-Dependent Expression of the Cadmium Transporter ZIP8
    Isamu Aiba, Anwar Hossain and Macus Tien Kuo
    Molecular Pharmacology September 2008, 74 (3) 823-833; DOI: https://doi.org/10.1124/mol.108.046862
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    Binding of Orthosteric Ligands to the Allosteric Site of the M2 Muscarinic Cholinergic Receptor
    Dar′ya S. Redka, Luca F. Pisterzi and James W. Wells
    Molecular Pharmacology September 2008, 74 (3) 834-843; DOI: https://doi.org/10.1124/mol.108.048074
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    Long-Term Nicotine Treatment Differentially Regulates Striatal α6α4β2* and α6(Nonα4)β2* nAChR Expression and Function
    Xiomara A. Perez, Tanuja Bordia, J. Michael McIntosh, Sharon R. Grady and Maryka Quik
    Molecular Pharmacology September 2008, 74 (3) 844-853; DOI: https://doi.org/10.1124/mol.108.048843
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    The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier
    Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas and I. David Goldman
    Molecular Pharmacology September 2008, 74 (3) 854-862; DOI: https://doi.org/10.1124/mol.108.045443
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    MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches
    Sheryl A. Flanagan, Christina M. Krokosky, Sudha Mannava, Mikhail A. Nikiforov and Donna S. Shewach
    Molecular Pharmacology September 2008, 74 (3) 863-871; DOI: https://doi.org/10.1124/mol.107.043349
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    Combinatorial Antileukemic Disruption of Oxidative Homeostasis and Mitochondrial Stability by the Redox Reactive Thalidomide 2-(2,4-Difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and Flavopiridol
    Yun Ge, Jung S. Byun, Paola De Luca, Geraldine Gueron, Idalia M. Yabe, Sara G. Sadiq-Ali, William D. Figg, Jesse Quintero, Cynthia M. Haggerty, Quentin Q. Li, Adriana De Siervi and Kevin Gardner
    Molecular Pharmacology September 2008, 74 (3) 872-883; DOI: https://doi.org/10.1124/mol.107.040808
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    Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia
    Federica Falà, William L. Blalock, Pier Luigi Tazzari, Alessandra Cappellini, Francesca Chiarini, Giovanni Martinelli, Agostino Tafuri, James A. McCubrey, Lucio Cocco and Alberto M. Martelli
    Molecular Pharmacology September 2008, 74 (3) 884-895; DOI: https://doi.org/10.1124/mol.108.047639
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    Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza
    David Marsolais, Bumsuk Hahm, Kurt H. Edelmann, Kevin B. Walsh, Miguel Guerrero, Yasuko Hatta, Yoshihiro Kawaoka, Edward Roberts, Michael B. A. Oldstone and Hugh Rosen
    Molecular Pharmacology September 2008, 74 (3) 896-903; DOI: https://doi.org/10.1124/mol.108.048769
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    Alternative Splicing of the Ca2+ Channel β4 Subunit Confers Specificity for Gabapentin Inhibition of Cav2.1 Trafficking
    Patrice M. Mich and William A. Horne
    Molecular Pharmacology September 2008, 74 (3) 904-912; DOI: https://doi.org/10.1124/mol.108.045153
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    Nuclear Receptor Coactivator 6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4α
    Sailesh Surapureddi, Ritu Rana, Janardan K. Reddy and Joyce A. Goldstein
    Molecular Pharmacology September 2008, 74 (3) 913-923; DOI: https://doi.org/10.1124/mol.108.048983

Errata

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    Correction to “Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27Kip1/Cyclin E Expression”
    Molecular Pharmacology September 2008, 74 (3) 924; DOI: https://doi.org/10.1124/mol.74.3.924
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    Correction to “Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter”
    Molecular Pharmacology September 2008, 74 (3) 924; DOI: https://doi.org/10.1124/mol.74.3.924-a
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Molecular Pharmacology: 74 (3)
Molecular Pharmacology
Vol. 74, Issue 3
1 Sep 2008
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