Table of Contents

Articles

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  Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells

  Masahiko Watabe and Toshio Nakaki

  Molecular Pharmacology October 2008, 74 (4) 933-940; DOI: https://doi.org/10.1124/mol.108.048546
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  Structural Determinants for Antagonist Pharmacology That Distinguish the ρ₁ GABA_C Receptor from GABA_A Receptors

  Jianliang Zhang, Fenqin Xue and Yongchang Chang

  Molecular Pharmacology October 2008, 74 (4) 941-951; DOI: https://doi.org/10.1124/mol.108.048710
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  Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor-γ Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Skin Repair

  Dana Schiefelbein, Oliver Seitz, Itamar Goren, Jan Philipp Dißmann, Helmut Schmidt, Malte Bachmann, Robert Sader, Gerd Geisslinger, Josef Pfeilschifter and Stefan Frank

  Molecular Pharmacology October 2008, 74 (4) 952-963; DOI: https://doi.org/10.1124/mol.108.049395
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  Functional Role of Arginine 375 in Transmembrane Helix 6 of Multidrug Resistance Protein 4 (MRP4/ABCC4)

  Azza A. K. El-Sheikh, Jeroen J. M. W. van den Heuvel, Elmar Krieger, Frans G. M. Russel and Jan B. Koenderink

  Molecular Pharmacology October 2008, 74 (4) 964-971; DOI: https://doi.org/10.1124/mol.107.043661
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  Differential Activation and Trafficking of μ-Opioid Receptors in Brain Slices

  Seksiri Arttamangkul, Nidia Quillinan, Malcolm J. Low, Mark von Zastrow, John Pintar and John T. Williams

  Molecular Pharmacology October 2008, 74 (4) 972-979; DOI: https://doi.org/10.1124/mol.108.048512
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  Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels

  Serge Guerreiro, Damien Toulorge, Etienne Hirsch, Marc Marien, Pierre Sokoloff and Patrick P. Michel

  Molecular Pharmacology October 2008, 74 (4) 980-989; DOI: https://doi.org/10.1124/mol.108.048207
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  Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity

  Namandjé N. Bumpus and Paul F. Hollenberg

  Molecular Pharmacology October 2008, 74 (4) 990-999; DOI: https://doi.org/10.1124/mol.108.048637
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  The α_1D-Adrenergic Receptor Induces Vascular Smooth Muscle Apoptosis via a p53-Dependent Mechanism

  Mary L. García-Cazarín, Jennifer L. Smith, Daret K. St. Clair and Michael T. Piascik

  Molecular Pharmacology October 2008, 74 (4) 1000-1007; DOI: https://doi.org/10.1124/mol.108.047993
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  Structural Motifs of Importance for the Constitutive Activity of the Orphan 7TM Receptor EBI2: Analysis of Receptor Activation in the Absence of an Agonist

  Tau Benned-Jensen and Mette M. Rosenkilde

  Molecular Pharmacology October 2008, 74 (4) 1008-1021; DOI: https://doi.org/10.1124/mol.108.049676
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  Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-α Involves Protein Kinase C-δ in Lung Epithelial Cells

  Christopher J. Clarke, J. Michael Guthrie and Yusuf A. Hannun

  Molecular Pharmacology October 2008, 74 (4) 1022-1032; DOI: https://doi.org/10.1124/mol.108.046250
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  Access and Binding of Local Anesthetics in the Closed Sodium Channel

  Iva Bruhova, Denis B. Tikhonov and Boris S. Zhorov

  Molecular Pharmacology October 2008, 74 (4) 1033-1045; DOI: https://doi.org/10.1124/mol.108.049759
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  The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy

  Yi-Lin Chen, Min-Hui Jian, Chai-Ching Lin, Jung-Cheng Kang, Shee-Ping Chen, Po-Cheng Lin, Putzer-Joseph Hung, Jen-Ren Chen, Wen-Liang Chang, Shinn-Zong Lin and Horng-Jyh Harn

  Molecular Pharmacology October 2008, 74 (4) 1046-1058; DOI: https://doi.org/10.1124/mol.107.044800
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  Identification of N-Terminal Receptor Activity-Modifying Protein Residues Important for Calcitonin Gene-Related Peptide, Adrenomedullin, and Amylin Receptor Function

  Tao Qi, George Christopoulos, Richard J. Bailey, Arthur Christopoulos, Patrick M. Sexton and Debbie L. Hay

  Molecular Pharmacology October 2008, 74 (4) 1059-1071; DOI: https://doi.org/10.1124/mol.108.047142
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  Patupilone-Induced Apoptosis Is Mediated by Mitochondrial Reactive Oxygen Species through Bim Relocalization to Mitochondria

  N. R. Khawaja, M. Carré, H. Kovacic, M. A. Estève and D. Braguer

  Molecular Pharmacology October 2008, 74 (4) 1072-1083; DOI: https://doi.org/10.1124/mol.108.048405
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  Human Proximal Tubular Epithelium Actively Secretes but Does Not Retain Rosuvastatin

  Anja Verhulst, Rachel Sayer, Marc E. De Broe, Patrick C. D'Haese and Colin D. A. Brown

  Molecular Pharmacology October 2008, 74 (4) 1084-1091; DOI: https://doi.org/10.1124/mol.108.047647
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  Dysregulation of Purine Nucleotide Biosynthesis Pathways Modulates Cisplatin Cytotoxicity in Saccharomyces cerevisiae

  David Kowalski, Lakshmi Pendyala, Bertrand Daignan-Fornier, Stephen B. Howell and Ruea-Yea Huang

  Molecular Pharmacology October 2008, 74 (4) 1092-1100; DOI: https://doi.org/10.1124/mol.108.048256
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  Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux

  Francesca Binda, Concetta Dipace, Erica Bowton, Sabrina D. Robertson, Brandon J. Lute, Jacob U. Fog, Minjia Zhang, Namita Sen, Roger J. Colbran, Margaret E. Gnegy, Ulrik Gether, Jonathan A. Javitch, Kevin Erreger and Aurelio Galli

  Molecular Pharmacology October 2008, 74 (4) 1101-1108; DOI: https://doi.org/10.1124/mol.108.048447
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  Histamine H2 Receptor Trafficking: Role of Arrestin, Dynamin, and Clathrin in Histamine H2 Receptor Internalization

  Natalia Fernandez, Federico Monczor, Alberto Baldi, Carlos Davio and Carina Shayo

  Molecular Pharmacology October 2008, 74 (4) 1109-1118; DOI: https://doi.org/10.1124/mol.108.045336
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  New Insights into the Function of M₄ Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

  Vindhya Nawaratne, Katie Leach, Nur Suratman, Richard E. Loiacono, Christian C. Felder, Blaine N. Armbruster, Bryan L. Roth, Patrick M. Sexton and Arthur Christopoulos

  Molecular Pharmacology October 2008, 74 (4) 1119-1131; DOI: https://doi.org/10.1124/mol.108.049353
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  Inhibition of Tumor Growth by Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger

  Jun-Jie Yin, Fang Lao, Jie Meng, Peter P. Fu, Yuliang Zhao, Gengmei Xing, Xueyun Gao, Baoyun Sun, Paul C. Wang, Chunying Chen and Xing-Jie Liang

  Molecular Pharmacology October 2008, 74 (4) 1132-1140; DOI: https://doi.org/10.1124/mol.108.048348
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  Selective Inhibition of Mitogen-Activated Protein Kinase Phosphatases by Zinc Accounts for Extracellular Signal-Regulated Kinase 1/2-Dependent Oxidative Neuronal Cell Death

  Yeung Ho, Ranmal Samarasinghe, Megan E. Knoch, Marcia Lewis, Elias Aizenman and Donald B. DeFranco

  Molecular Pharmacology October 2008, 74 (4) 1141-1151; DOI: https://doi.org/10.1124/mol.108.049064
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  Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites

  Verawan Uchaipichat, Aleksandra Galetin, J. Brian Houston, Peter I. Mackenzie, J. Andrew Williams and John O. Miners

  Molecular Pharmacology October 2008, 74 (4) 1152-1162; DOI: https://doi.org/10.1124/mol.108.048645
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  Mutations to the Kainate Receptor Subunit GluR6 Binding Pocket That Selectively Affect Domoate Binding

  Yihong Zhang, Naushaba Nayeem and Tim Green

  Molecular Pharmacology October 2008, 74 (4) 1163-1169; DOI: https://doi.org/10.1124/mol.108.048819