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Research ArticleArticle

New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Vindhya Nawaratne, Katie Leach, Nur Suratman, Richard E. Loiacono, Christian C. Felder, Blaine N. Armbruster, Bryan L. Roth, Patrick M. Sexton and Arthur Christopoulos
Molecular Pharmacology October 2008, 74 (4) 1119-1131; DOI: https://doi.org/10.1124/mol.108.049353

Article Information

vol. 74 no. 4 1119-1131
DOI 
https://doi.org/10.1124/mol.108.049353
PubMed 
18628403
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 29, 2008
  • Accepted July 14, 2008
  • Published online September 18, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Vindhya Nawaratne,
  2. Katie Leach,
  3. Nur Suratman,
  4. Richard E. Loiacono,
  5. Christian C. Felder,
  6. Blaine N. Armbruster,
  7. Bryan L. Roth,
  8. Patrick M. Sexton and
  9. Arthur Christopoulos
  1. Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Melbourne, Australia (V.N., K.L., N.S., R.E.L., P.M.S., A.C.), Neuroscience, Lilly Corporate Center, Indianapolis, Indiana (C.C.F.); Millipore Inc., St. Louis, Missouri (B.N.A.); and Departments of Pharmacology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, North Carolina (B.L.R.)
  1. Address correspondence to:
    Prof. Arthur Christopoulos, Drug Discovery Biology Laboratory, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. E-mail: arthur.christopoulos{at}med.monash.edu.au
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Research ArticleArticle

New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Vindhya Nawaratne, Katie Leach, Nur Suratman, Richard E. Loiacono, Christian C. Felder, Blaine N. Armbruster, Bryan L. Roth, Patrick M. Sexton and Arthur Christopoulos
Molecular Pharmacology October 1, 2008, 74 (4) 1119-1131; DOI: https://doi.org/10.1124/mol.108.049353
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