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Research ArticleArticle

Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites

Verawan Uchaipichat, Aleksandra Galetin, J. Brian Houston, Peter I. Mackenzie, J. Andrew Williams and John O. Miners
Molecular Pharmacology October 2008, 74 (4) 1152-1162; DOI: https://doi.org/10.1124/mol.108.048645

Article Information

vol. 74 no. 4 1152-1162
DOI 
https://doi.org/10.1124/mol.108.048645
PubMed 
18647858
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 5, 2008
  • Accepted July 21, 2008
  • Published online September 18, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Verawan Uchaipichat,
  2. Aleksandra Galetin,
  3. J. Brian Houston,
  4. Peter I. Mackenzie,
  5. J. Andrew Williams and
  6. John O. Miners
  1. Department of Clinical Pharmacology, Flinders University, Adelaide, Australia (V.U., P.I.M., J.O.M.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (A.G., J.B.H.); and Molecular Medicine, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California (J.A.W.).
  1. Address correspondence to:
    Professor John Miners, Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, SA 5042. Australia, E-mail: john.miners{at}flinders.edu.au
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Research ArticleArticle

Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites

Verawan Uchaipichat, Aleksandra Galetin, J. Brian Houston, Peter I. Mackenzie, J. Andrew Williams and John O. Miners
Molecular Pharmacology October 1, 2008, 74 (4) 1152-1162; DOI: https://doi.org/10.1124/mol.108.048645
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