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Molecular Pharmacology

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Table of Contents

November 01, 2008; Volume 74,Issue 5

MINIREVIEW

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    Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and New Targets for Therapeutic Intervention
    Alexander R. Mackie and Kenneth L. Byron
    Molecular Pharmacology November 2008, 74 (5) 1171-1179; DOI: https://doi.org/10.1124/mol.108.049825

Perspective

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    Sensitization of Nociceptive Ion Channels by Inhaled Anesthetics—A Pain in the Gas?
    Neil Harrison and Carla Nau
    Molecular Pharmacology November 2008, 74 (5) 1180-1182; DOI: https://doi.org/10.1124/mol.108.051615

Articles

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    Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model
    Wassana Wijagkanalan, Yuriko Higuchi, Shigeru Kawakami, Mugen Teshima, Hitoshi Sasaki and Mitsuru Hashida
    Molecular Pharmacology November 2008, 74 (5) 1183-1192; DOI: https://doi.org/10.1124/mol.108.050153
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    Identification of a Putative Intracellular Allosteric Antagonist Binding-Site in the CXC Chemokine Receptors 1 and 2
    David J. Nicholls, Nick P. Tomkinson, Katherine E. Wiley, Anne Brammall, Lorna Bowers, Caroline Grahames, Alasdair Gaw, Premji Meghani, Philip Shelton, Tracey J. Wright and Philip R. Mallinder
    Molecular Pharmacology November 2008, 74 (5) 1193-1202; DOI: https://doi.org/10.1124/mol.107.044610
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    1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion
    Angelika Klose, Tobias Huth and Christian Alzheimer
    Molecular Pharmacology November 2008, 74 (5) 1203-1214; DOI: https://doi.org/10.1124/mol.108.047837
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    Dynamic Effect of Bortezomib on Nuclear Factor-κB Activity and Gene Expression in Tumor Cells
    Myong-Hee Sung, Lorena Bagain, Zhong Chen, Tatiana Karpova, Xinping Yang, Christopher Silvin, Ty C. Voss, James G. McNally, Carter Van Waes and Gordon L. Hager
    Molecular Pharmacology November 2008, 74 (5) 1215-1222; DOI: https://doi.org/10.1124/mol.108.049114
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    Differential Signaling Pathways in Angiotensin II- and Epidermal Growth Factor-stimulated Hepatic C9 Cells
    Xing Yin, Bo Li, Hungdar Chen and Kevin J. Catt
    Molecular Pharmacology November 2008, 74 (5) 1223-1233; DOI: https://doi.org/10.1124/mol.108.048504
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    Reactive Oxygen Species Mediate p53 Activation and Apoptosis Induced by Sodium Nitroprusside in SH-SY5Y Cells
    Simone Cardaci, Giuseppe Filomeni, Giuseppe Rotilio and Maria R. Ciriolo
    Molecular Pharmacology November 2008, 74 (5) 1234-1245; DOI: https://doi.org/10.1124/mol.108.048975
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    Role of Key Transmembrane Residues in Agonist and Antagonist Actions at the Two Conformations of the Human β1-Adrenoceptor
    Jillian G. Baker, Richard G. W. Proudman, Nicola C. Hawley, Peter M. Fischer and Stephen J. Hill
    Molecular Pharmacology November 2008, 74 (5) 1246-1260; DOI: https://doi.org/10.1124/mol.108.048371
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    General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1
    Paul M. Cornett, José A. Matta and Gerard P. Ahern
    Molecular Pharmacology November 2008, 74 (5) 1261-1268; DOI: https://doi.org/10.1124/mol.108.049684
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    Ligand-Mediated Regulation of Peroxisome Proliferator-Activated Receptor (PPAR) β/δ: A Comparative Analysis of PPAR-Selective Agonists and All-trans Retinoic Acid
    Markus Rieck, Wolfgang Meissner, Simone Ries, Sabine Müller-Brüsselbach and Rolf Müller
    Molecular Pharmacology November 2008, 74 (5) 1269-1277; DOI: https://doi.org/10.1124/mol.108.050625
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    Morphine Desensitization, Internalization, and Down-Regulation of the μ Opioid Receptor Is Facilitated by Serotonin 5-Hydroxytryptamine2A Receptor Coactivation
    Juan F. Lopez-Gimenez, M. Teresa Vilaró and Graeme Milligan
    Molecular Pharmacology November 2008, 74 (5) 1278-1291; DOI: https://doi.org/10.1124/mol.108.048272
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    Mitochondria-Dependent Reactive Oxygen Species-Mediated Programmed Cell Death Induced by 3,3′-Diindolylmethane through Inhibition of F0F1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani
    Amit Roy, Agneyo Ganguly, Somdeb BoseDasgupta, Benu Brata Das, Churala Pal, Parasuraman Jaisankar and Hemanta K. Majumder
    Molecular Pharmacology November 2008, 74 (5) 1292-1307; DOI: https://doi.org/10.1124/mol.108.050161
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    Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions
    Pedro J. Gonzalez-Cabrera, Euijung Jo, M. Germana Sanna, Steven Brown, Nora Leaf, David Marsolais, Marie-Therese Schaeffer, Jacqueline Chapman, Michael Cameron, Miguel Guerrero, Edward Roberts and Hugh Rosen
    Molecular Pharmacology November 2008, 74 (5) 1308-1318; DOI: https://doi.org/10.1124/mol.108.049783
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    Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene
    Ling-Chang Kung, Samuel H. H. Chan, Kay L. H. Wu, Chen-Chun Ou, Ming-Hon Tai and Julie Y. H. Chan
    Molecular Pharmacology November 2008, 74 (5) 1319-1332; DOI: https://doi.org/10.1124/mol.108.048793
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    Coassembly of Different Sulfonylurea Receptor Subtypes Extends the Phenotypic Diversity of ATP-sensitive Potassium (KATP) Channels
    Adam Wheeler, Chuan Wang, Ke Yang, Kun Fang, Kevin Davis, Amanda M. Styer, Uyenlinh Mirshahi, Christophe Moreau, Jean Revilloud, Michel Vivaudou, Shunhe Liu, Tooraj Mirshahi and Kim W. Chan
    Molecular Pharmacology November 2008, 74 (5) 1333-1344; DOI: https://doi.org/10.1124/mol.108.048355
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    Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
    Colleen M. Niswender, Kari A. Johnson, C. David Weaver, Carrie K. Jones, Zixiu Xiang, Qingwei Luo, Alice L. Rodriguez, Joy E. Marlo, Tomas de Paulis, Analisa D. Thompson, Emily L. Days, Tasha Nalywajko, Cheryl A. Austin, Michael Baxter Williams, Jennifer E. Ayala, Richard Williams, Craig W. Lindsley and P. Jeffrey Conn
    Molecular Pharmacology November 2008, 74 (5) 1345-1358; DOI: https://doi.org/10.1124/mol.108.049551
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    Interleukin-8 Expression Is Regulated by Histone Deacetylases through the Nuclear Factor-κB Pathway in Breast Cancer
    Carine Chavey, Marcus Mühlbauer, Carine Bossard, Ariane Freund, Sébastien Durand, Christian Jorgensen, Christian Jobin and Gwendal Lazennec
    Molecular Pharmacology November 2008, 74 (5) 1359-1366; DOI: https://doi.org/10.1124/mol.108.047332
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    A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse
    Bernice C. Lin, Linh P. Nguyen, Jacqueline A. Walisser and Christopher A. Bradfield
    Molecular Pharmacology November 2008, 74 (5) 1367-1371; DOI: https://doi.org/10.1124/mol.108.047068
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    The Role of Human Nucleoside Transporters in Uptake of 3′-Deoxy-3′-fluorothymidine
    Robert J. Paproski, Amy M. L. Ng, Sylvia Y. M. Yao, Kathryn Graham, James D. Young and Carol E. Cass
    Molecular Pharmacology November 2008, 74 (5) 1372-1380; DOI: https://doi.org/10.1124/mol.108.048900
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    Anti-Inflammatory, Antiproliferative, and Cytoprotective Activity of NO Chimera Nitrates of Use in Cancer Chemoprevention
    Ghenet K. Hagos, Samer O. Abdul-Hay, Johann Sohn, Praneeth D. Edirisinghe, R. Esala P. Chandrasena, Zhiqiang Wang, Qian Li and Gregory R. J. Thatcher
    Molecular Pharmacology November 2008, 74 (5) 1381-1391; DOI: https://doi.org/10.1124/mol.108.046664
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    Muscarinic Modulation of Synaptic Transmission via Endocannabinoid Signalling in the Rat Midbrain Periaqueductal Gray
    Benjamin K. Lau and Christopher W. Vaughan
    Molecular Pharmacology November 2008, 74 (5) 1392-1398; DOI: https://doi.org/10.1124/mol.108.045872
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    Nonsteroidal Anti-Inflammatory Drugs Induced Endothelial Apoptosis by Perturbing Peroxisome Proliferator-Activated Receptor-δ Transcriptional Pathway
    Jun-Yang Liou, Chia-Ching Wu, Bo-Rui Chen, Linju B. Yen and Kenneth K. Wu
    Molecular Pharmacology November 2008, 74 (5) 1399-1406; DOI: https://doi.org/10.1124/mol.108.049569
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    Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment
    Daniel Bertrand, Sonia Bertrand, Steven Cassar, Earl Gubbins, Jinhe Li and M. Gopalakrishnan
    Molecular Pharmacology November 2008, 74 (5) 1407-1416; DOI: https://doi.org/10.1124/mol.107.042820
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    The β3-Adrenoceptor Agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and Antagonist (S)-N-[4-[2-[[3-[3-(Acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) Activate Different Signaling Pathways in Chinese Hamster Ovary-K1 Cells Stably Expressing the Human β3-Adrenoceptor
    Masaaki Sato, Dana S. Hutchinson, Bronwyn A. Evans and Roger J. Summers
    Molecular Pharmacology November 2008, 74 (5) 1417-1428; DOI: https://doi.org/10.1124/mol.108.046979
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    Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/δ Inhibits Cell Proliferation in Human HaCaT Keratinocytes
    Michael G. Borland, Jennifer E. Foreman, Elizabeth E. Girroir, Reza Zolfaghari, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, A. Catharine Ross and Jeffrey M. Peters
    Molecular Pharmacology November 2008, 74 (5) 1429-1442; DOI: https://doi.org/10.1124/mol.108.050609
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    Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-à-go-go-Related Gene Channels
    Mark J. Perrin, Philip W. Kuchel, Terence J. Campbell and Jamie I. Vandenberg
    Molecular Pharmacology November 2008, 74 (5) 1443-1452; DOI: https://doi.org/10.1124/mol.108.049056
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    Phosphodiesterase 4 and Phosphatase 2A Differentially Regulate cAMP/Protein Kinase A Signaling for Cardiac Myocyte Contraction under Stimulation of β1 Adrenergic Receptor
    Vania De Arcangelis, Dagoberto Soto and Yang Xiang
    Molecular Pharmacology November 2008, 74 (5) 1453-1462; DOI: https://doi.org/10.1124/mol.108.049718
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    Cross-Talk between Dopaminergic and Noradrenergic Systems in the Rat Ventral Tegmental Area, Locus Ceruleus, and Dorsal Hippocampus
    Bruno P. Guiard, Mostafa El Mansari and Pierre Blier
    Molecular Pharmacology November 2008, 74 (5) 1463-1475; DOI: https://doi.org/10.1124/mol.108.048033
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    ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
    William A. Schmalhofer, Jeffrey Calhoun, Rachel Burrows, Timothy Bailey, Martin G. Kohler, Adam B. Weinglass, Gregory J. Kaczorowski, Maria L. Garcia, Martin Koltzenburg and Birgit T. Priest
    Molecular Pharmacology November 2008, 74 (5) 1476-1484; DOI: https://doi.org/10.1124/mol.108.047670
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Molecular Pharmacology: 74 (5)
Molecular Pharmacology
Vol. 74, Issue 5
1 Nov 2008
  • Table of Contents
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