Abstract
A remarkable new article in this issue of Molecular Pharmacology (p. 1261) shows that the capsaicin-sensitive ion channel TRPV1 is sensitized to activation by chemical and physical stimuli in the presence of inhaled general anesthetics. This finding provides another example of an ion channel in which the anesthetic acts to modify channel gating. This may have important clinical implications in view of the role of TRPV1 in nociception.
Footnotes
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Please see the related article on page 1261.
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ABBREVIATIONS: IGA, inhaled general anesthetic; ISO, isoflurane; TRPV1, transient receptor potential V1.
- Received September 3, 2008.
- Accepted September 3, 2008.
- The American Society for Pharmacology and Experimental Therapeutics
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