Table of Contents

Articles

• You have access

  Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors

  Rebecca S. Y. Wong, Veronique Bodart, Markus Metz, Jean Labrecque, Gary Bridger and Simon P. Fricker

  Molecular Pharmacology December 2008, 74 (6) 1485-1495; DOI: https://doi.org/10.1124/mol.108.049775
• You have access

  Multiple Pharmacophores for the Selective Activation of Nicotinic α7-Type Acetylcholine Receptors

  Nicole A. Horenstein, Fedra M. Leonik and Roger L. Papke

  Molecular Pharmacology December 2008, 74 (6) 1496-1511; DOI: https://doi.org/10.1124/mol.108.048892
• You have access

  Structural Basis of Human Pregnane X Receptor Activation by the Hops Constituent Colupulone

  Denise G. Teotico, Jason J. Bischof, Li Peng, Steven A. Kliewer and Matthew R. Redinbo

  Molecular Pharmacology December 2008, 74 (6) 1512-1520; DOI: https://doi.org/10.1124/mol.108.050732
• You have access

  The Orphan Transporter Rxt1/NTT4 (SLC6A17) Functions as a Synaptic Vesicle Amino Acid Transporter Selective for Proline, Glycine, Leucine, and Alanine

  Leonardo A. Parra, Tracy Baust, Salah El Mestikawy, Marisol Quiroz, Beth Hoffman, Jack M. Haflett, Jeffrey K. Yao and Gonzalo E. Torres

  Molecular Pharmacology December 2008, 74 (6) 1521-1532; DOI: https://doi.org/10.1124/mol.108.050005
• You have access

  17-β-Estradiol Inhibits Transforming Growth Factor-β Signaling and Function in Breast Cancer Cells via Activation of Extracellular Signal-Regulated Kinase through the G Protein-Coupled Receptor 30

  Burkhard Kleuser, Daniela Malek, Ronald Gust, Heinz H. Pertz and Henrik Potteck

  Molecular Pharmacology December 2008, 74 (6) 1533-1543; DOI: https://doi.org/10.1124/mol.108.046854
• You have access

  Aryl Hydrocarbon Receptor-Mediated Down-Regulation of Sox9b Causes Jaw Malformation in Zebrafish Embryos

  Kong M. Xiong, Richard E. Peterson and Warren Heideman

  Molecular Pharmacology December 2008, 74 (6) 1544-1553; DOI: https://doi.org/10.1124/mol.108.050435
• You have access

  Different Interactions between MT7 Toxin and the Human Muscarinic M₁ Receptor in Its Free and N-Methylscopolamine-Occupied States

  Carole Fruchart-Gaillard, Gilles Mourier, Catherine Marquer, Enrico Stura, Nigel J. M. Birdsall and Denis Servent

  Molecular Pharmacology December 2008, 74 (6) 1554-1563; DOI: https://doi.org/10.1124/mol.108.050773
• You have access

  Overexpression of Heme Oxygenase-1 Protects Dopaminergic Neurons against 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

  Shih-Ya Hung, Houng-Chi Liou, Kai-Hsiang Kang, Ruey-Meei Wu, Chun-Chiang Wen and Wen-Mei Fu

  Molecular Pharmacology December 2008, 74 (6) 1564-1575; DOI: https://doi.org/10.1124/mol.108.048611
• You have access

  Identification of Quinolines that Inhibit Melanogenesis by Altering Tyrosinase Family Trafficking

  Li Ni-Komatsu, ChunXiang Tong, Guangming Chen, Nelya Brindzei and Seth J. Orlow

  Molecular Pharmacology December 2008, 74 (6) 1576-1586; DOI: https://doi.org/10.1124/mol.108.050633
• You have access

  Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors

  Tobias Eltze, Rainer Boer, Thomas Wagner, Steffen Weinbrenner, Michelle C. McDonald, Christoph Thiemermann, Alexander Bürkle and Thomas Klein

  Molecular Pharmacology December 2008, 74 (6) 1587-1598; DOI: https://doi.org/10.1124/mol.108.048751
• You have access

  Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

  Taeweon Lee, Ralf Schwandner, Gayathri Swaminath, Jennifer Weiszmann, Mario Cardozo, Joanne Greenberg, Peter Jaeckel, Hongfei Ge, Yingcai Wang, Xianyun Jiao, Jiwen Liu, Frank Kayser, Hui Tian and Yang Li

  Molecular Pharmacology December 2008, 74 (6) 1599-1609; DOI: https://doi.org/10.1124/mol.108.049536
• You have access

  Endoplasmic Reticulum Stress Induces Leptin Resistance

  Toru Hosoi, Miyako Sasaki, Tsuyoshi Miyahara, Chie Hashimoto, Suguru Matsuo, Michiko Yoshii and Koichiro Ozawa

  Molecular Pharmacology December 2008, 74 (6) 1610-1619; DOI: https://doi.org/10.1124/mol.108.050070
• You have access

  Rebeccamycin Derivatives as Dual DNA-Damaging Agents and Potent Checkpoint Kinase 1 Inhibitors

  Christelle Marminon, Fabrice Anizon, Pascale Moreau, Bruno Pfeiffer, Alain Pierré, Roy M. Golsteyn, Paul Peixoto, Marie-Paule Hildebrand, Marie-Hélène David-Cordonnier, Olivier Lozach, Laurent Meijer and Michelle Prudhomme

  Molecular Pharmacology December 2008, 74 (6) 1620-1629; DOI: https://doi.org/10.1124/mol.108.049346
• You have access

  Mechanistic Differences between GSH Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) and GSH Modulation of MRP1-Mediated Transport

  Alice Rothnie, Gwenaëlle Conseil, Andrea Y. T. Lau, Roger G. Deeley and Susan P. C. Cole

  Molecular Pharmacology December 2008, 74 (6) 1630-1640; DOI: https://doi.org/10.1124/mol.108.049080
• You have access

  Nicotine Relieves Anxiogenic-Like Behavior in Mice that Overexpress the Read-Through Variant of Acetylcholinesterase but Not in Wild-Type Mice

  R. Salas, A. Main, D. A. Gangitano, G. Zimmerman, S. Ben-Ari, H. Soreq and M. De Biasi

  Molecular Pharmacology December 2008, 74 (6) 1641-1648; DOI: https://doi.org/10.1124/mol.108.048454
• You have access

  12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid [12(R)-HETE], an Arachidonic Acid Derivative, Is an Activator of the Aryl Hydrocarbon Receptor

  Christopher. R. Chiaro, Rushang D. Patel and Gary. H. Perdew

  Molecular Pharmacology December 2008, 74 (6) 1649-1656; DOI: https://doi.org/10.1124/mol.108.049379
• You have access

  Dissecting the Role of Multiple Reductases in Bioactivation and Cytotoxicity of the Antitumor Agent 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1)

  Chao Yan, Jadwiga K. Kepa, David Siegel, Ian J. Stratford and David Ross

  Molecular Pharmacology December 2008, 74 (6) 1657-1665; DOI: https://doi.org/10.1124/mol.108.050401
• You have access

  P2Y₁ Receptor Activation Elicits Its Partition out of Membrane Rafts and Its Rapid Internalization from Human Blood Vessels: Implications for Receptor Signaling

  Andrés Norambuena, M. Inés Poblete, M. Verónica Donoso, C. Sofía Espinoza, Alfonso González and J. Pablo Huidobro-Toro

  Molecular Pharmacology December 2008, 74 (6) 1666-1677; DOI: https://doi.org/10.1124/mol.108.048496
• You have access

  The Cannabinoid CB1 Receptor Antagonist Rimonabant Stimulates 2-Deoxyglucose Uptake in Skeletal Muscle Cells by Regulating the Expression of Phosphatidylinositol-3-kinase

  Iolanda Esposito, Maria Chiara Proto, Patrizia Gazzerro, Chiara Laezza, Claudia Miele, Anna Teresa Alberobello, Vittoria D'Esposito, Francesco Beguinot, Pietro Formisano and Maurizio Bifulco

  Molecular Pharmacology December 2008, 74 (6) 1678-1686; DOI: https://doi.org/10.1124/mol.108.049205
• You have access

  Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on α₁ or β₂ Subunits Enhance GABA_A Receptor Gating and Reduce Etomidate Modulation

  Deirdre Stewart, Rooma Desai, Qi Cheng, Aiping Liu and Stuart A. Forman

  Molecular Pharmacology December 2008, 74 (6) 1687-1695; DOI: https://doi.org/10.1124/mol.108.050500
• You have access

  Potent Activation of Large-Conductance Ca²⁺-Activated K⁺ Channels by the Diphenylurea 1,3-Bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in Pituitary Tumor (GH₃) Cells

  Sheng-Nan Wu, Hsung Peng, Bing-Shuo Chen, Ya-Jean Wang, Pei-Yu Wu and Ming-Wei Lin

  Molecular Pharmacology December 2008, 74 (6) 1696-1704; DOI: https://doi.org/10.1124/mol.108.049106
• You have access

  Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites

  Mario Mezler, Wilfried Hornberger, Reinhold Mueller, Martin Schmidt, Willi Amberg, Wilfried Braje, Michael Ochse, Hans Schoemaker and Berthold Behl

  Molecular Pharmacology December 2008, 74 (6) 1705-1715; DOI: https://doi.org/10.1124/mol.108.049312
• You have access

  The Selective Alzheimer's Disease Indicator-1 Gene (Seladin-1/DHCR24) Is a Liver X Receptor Target Gene

  Yongjun Wang, Pamela M. Rogers, Keith R. Stayrook, Chen Su, Gabor Varga, Qi Shen, Sunil Nagpal and Thomas P. Burris

  Molecular Pharmacology December 2008, 74 (6) 1716-1721; DOI: https://doi.org/10.1124/mol.108.048538
• You have access

  Mechanisms of Myocyte Cytotoxicity Induced by the Multiple Receptor Tyrosine Kinase Inhibitor Sunitinib

  Brian B. Hasinoff, Daywin Patel and Kimberley A. O'Hara

  Molecular Pharmacology December 2008, 74 (6) 1722-1728; DOI: https://doi.org/10.1124/mol.108.050104