Molecular Pharmacology: 75 (1)

January 01, 2009; Volume 75,Issue 1

MINIREVIEW

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Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins, Adrenergic and Adenosine Receptors
Debarshi Mustafi and Krzysztof Palczewski

Molecular Pharmacology January 2009, 75 (1) 1-12; DOI: https://doi.org/10.1124/mol.108.051938

Perspective

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Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities
Roland Seifert and Stefan Dove

Molecular Pharmacology January 2009, 75 (1) 13-18; DOI: https://doi.org/10.1124/mol.108.052944

Articles

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An Intracellular Loop 2 Amino Acid Residue Determines Differential Binding of Arrestin to the Dopamine D₂ and D₃ Receptors
Hongxiang Lan, Martha M. Teeter, Vsevolod V. Gurevich and Kim A. Neve

Molecular Pharmacology January 2009, 75 (1) 19-26; DOI: https://doi.org/10.1124/mol.108.050542
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Hydrogen Sulfide Inhibits Rotenone-Induced Apoptosis via Preservation of Mitochondrial Function
Li-Fang Hu, Ming Lu, Zhi-Yuan Wu, Peter T.-H. Wong and Jin-Song Bian

Molecular Pharmacology January 2009, 75 (1) 27-34; DOI: https://doi.org/10.1124/mol.108.047985
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Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis
David. L. Carbone, Katriana A. Popichak, Julie A. Moreno, Stephen Safe and Ronald B. Tjalkens

Molecular Pharmacology January 2009, 75 (1) 35-43; DOI: https://doi.org/10.1124/mol.108.050781
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Overlapping Binding Site for the Endogenous Agonist, Small-Molecule Agonists, and Ago-allosteric Modulators on the Ghrelin Receptor
Birgitte Holst, Thomas M. Frimurer, Jacek Mokrosinski, Tine Halkjaer, Karina B. Cullberg, Christina R. Underwood and Thue W. Schwartz

Molecular Pharmacology January 2009, 75 (1) 44-59; DOI: https://doi.org/10.1124/mol.108.049189
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Structural Basis of NR2B-Selective Antagonist Recognition by N-Methyl-d-aspartate Receptors
Laetitia Mony, Lucie Krzaczkowski, Manuel Leonetti, Anne Le Goff, Karine Alarcon, Jacques Neyton, Hughes-Olivier Bertrand, Francine Acher and Pierre Paoletti

Molecular Pharmacology January 2009, 75 (1) 60-74; DOI: https://doi.org/10.1124/mol.108.050971
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Imatinib Mesylate (STI571)-Induced Cell Edge Translocation of Kinase-Active and Kinase-Defective Abelson Kinase: Requirements of Myristoylation and src Homology 3 Domain
Akiko Fujita, Tomoyuki Shishido, Yunfeng Yuan, Eiji Inamoto, Shuh Narumiya and Naoki Watanabe

Molecular Pharmacology January 2009, 75 (1) 75-84; DOI: https://doi.org/10.1124/mol.108.051706
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Flow Cytometry-Based Binding Assay for GPR40 (FFAR1; Free Fatty Acid Receptor 1)
Takafumi Hara, Akira Hirasawa, Qi Sun, Taka-aki Koshimizu, Chisato Itsubo, Keiko Sadakane, Takeo Awaji and Gozoh Tsujimoto

Molecular Pharmacology January 2009, 75 (1) 85-91; DOI: https://doi.org/10.1124/mol.108.052225
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Inhibition of P-Glycoprotein-Mediated Paclitaxel Resistance by Reversibly Linked Quinine Homodimers
Marcos M. Pires, Dana Emmert, Christine A. Hrycyna and Jean Chmielewski

Molecular Pharmacology January 2009, 75 (1) 92-100; DOI: https://doi.org/10.1124/mol.108.050492
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Phenylephrine-Induced Cardiomyocyte Injury Is Triggered by Superoxide Generation through Uncoupled Endothelial Nitric-Oxide Synthase and Ameliorated by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a Novel Calmodulin Antagonist
Ying-Mei Lu, Feng Han, Norifumi Shioda, Shigeki Moriguchi, Yasufumi Shirasaki, Zheng-Hong Qin and Kohji Fukunaga

Molecular Pharmacology January 2009, 75 (1) 101-112; DOI: https://doi.org/10.1124/mol.108.050716
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A Dopamine D₂ Receptor Mutant Capable of G Protein-Mediated Signaling but Deficient in Arrestin Binding
Hongxiang Lan, Yong Liu, Michal I. Bell, Vsevolod V. Gurevich and Kim A. Neve

Molecular Pharmacology January 2009, 75 (1) 113-123; DOI: https://doi.org/10.1124/mol.108.050534
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90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G₂/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1
Archie N. Tse, Tahir N. Sheikh, Ho Alan, Ting-Chao Chou and Gary K. Schwartz

Molecular Pharmacology January 2009, 75 (1) 124-133; DOI: https://doi.org/10.1124/mol.108.050807
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Thiophenecarboxylate Suppressor of Cyclic Nucleotides Discovered in a Small-Molecule Screen Blocks Toxin-Induced Intestinal Fluid Secretion
Lukmanee Tradtrantip, Buranee Yangthara, Prashant Padmawar, Christopher Morrison and A. S. Verkman

Molecular Pharmacology January 2009, 75 (1) 134-142; DOI: https://doi.org/10.1124/mol.108.050567
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Short-Chain Ubiquitination Is Associated with the Degradation Rate of a Cell-Surface-Resident Bile Salt Export Pump (BSEP/ABCB11)
Hisamitsu Hayashi and Yuichi Sugiyama

Molecular Pharmacology January 2009, 75 (1) 143-150; DOI: https://doi.org/10.1124/mol.108.049288
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Vanillin Inhibits Matrix Metalloproteinase-9 Expression through Down-Regulation of Nuclear Factor-κB Signaling Pathway in Human Hepatocellular Carcinoma Cells
Ji-An Liang, Shih-Lu Wu, Hsin-Yi Lo, Chien-Yun Hsiang and Tin-Yun Ho

Molecular Pharmacology January 2009, 75 (1) 151-157; DOI: https://doi.org/10.1124/mol.108.049502
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Stereochemistry of an Agonist Determines Coupling Preference of β₂-Adrenoceptor to Different G Proteins in Cardiomyocytes
Anthony Yiu-Ho Woo, Tian-Bing Wang, Xiaokun Zeng, Weizhong Zhu, Darrell R. Abernethy, Irving W. Wainer and Rui-Ping Xiao

Molecular Pharmacology January 2009, 75 (1) 158-165; DOI: https://doi.org/10.1124/mol.108.051078
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Site Selectivity of Competitive Antagonists for the Mouse Adult Muscle Nicotinic Acetylcholine Receptor
Man Liu and James P. Dilger

Molecular Pharmacology January 2009, 75 (1) 166-173; DOI: https://doi.org/10.1124/mol.108.051060
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Copper Regulation of Hypoxia-Inducible Factor-1 Activity
Wenke Feng, Fei Ye, Wanli Xue, Zhanxiang Zhou and Y. James Kang

Molecular Pharmacology January 2009, 75 (1) 174-182; DOI: https://doi.org/10.1124/mol.108.051516
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Amitriptyline Activates Cardiac Ryanodine Channels and Causes Spontaneous Sarcoplasmic Reticulum Calcium Release
Nagesh Chopra, Derek Laver, Sean S. Davies and Björn C. Knollmann

Molecular Pharmacology January 2009, 75 (1) 183-195; DOI: https://doi.org/10.1124/mol.108.051490
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Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells
Lindsay Marek, Kathryn E. Ware, Alexa Fritzsche, Paula Hercule, Wallace R. Helton, Jennifer E. Smith, Lee A. McDermott, Christopher D. Coldren, Raphael A. Nemenoff, Daniel T. Merrick, Barbara A. Helfrich, Paul A. Bunn and Lynn E. Heasley

Molecular Pharmacology January 2009, 75 (1) 196-207; DOI: https://doi.org/10.1124/mol.108.049544
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YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells
Xiao-ming Liu, Kelly J. Peyton, Natalia N. Mendelev, Hong Wang, David A. Tulis and William Durante

Molecular Pharmacology January 2009, 75 (1) 208-217; DOI: https://doi.org/10.1124/mol.108.048314
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Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity
Ruoli Bai, Michael C. Edler, Peter L. Bonate, Terry D. Copeland, George R. Pettit, Richard F. Ludueña and Ernest Hamel

Molecular Pharmacology January 2009, 75 (1) 218-226; DOI: https://doi.org/10.1124/mol.108.051110
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Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation
Emily J. Welch, Ram P. Naikawadi, Zhenyu Li, Phoebe Lin, Satoshi Ishii, Takao Shimizu, Chinnaswamy Tiruppathi, Xiaoping Du, Papasani V. Subbaiah and Richard D. Ye

Molecular Pharmacology January 2009, 75 (1) 227-234; DOI: https://doi.org/10.1124/mol.108.051003
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The G_q and G₁₂ Families of Heterotrimeric G Proteins Report Functional Selectivity
Li Zhang, Lawrence F. Brass and David R. Manning

Molecular Pharmacology January 2009, 75 (1) 235-241; DOI: https://doi.org/10.1124/mol.108.050906
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Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners
Sang Mi Shin and Sang Geon Kim

Molecular Pharmacology January 2009, 75 (1) 242-253; DOI: https://doi.org/10.1124/mol.108.051128

Errata

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Correction to “The NR1 M3 Domain Mediates Allosteric Coupling in the N-Methyl-d-aspartate Receptor”
Molecular Pharmacology January 2009, 75 (1) 254-257; DOI: https://doi.org/10.1124/mol.75.1.254
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Correction to “Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites”
Molecular Pharmacology January 2009, 75 (1) 258; DOI: https://doi.org/10.1124/mol.75.1.258
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Correction to Table of Contents (Volume 74, Number 6, December 2008)
Molecular Pharmacology January 2009, 75 (1) 258; DOI: https://doi.org/10.1124/mol.75.1.258-a

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