Abstract
The mammalian nervous system exerts essential control on many physiological processes in the organism and is itself controlled extensively by a variety of genetic regulatory mechanisms. MicroRNAs, a class of small, noncoding RNAs, are critical contributors to the regulation of gene expression in the nervous system. Emerging evidence indicates that microRNAs regulate both the development and function of the nervous system. Deficiency in microRNA function has also been implicated in a number of neurological disorders. Understanding the roles of microRNAs will provide new insights into the complexity and operation of the nervous system.
Footnotes
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This work was supported in part by the National Institutes of Health National Institute on Drug Abuse [Grant P50-DA011806] and the Minnesota Medical Foundation [Grant 3674-9227-06].
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ABBREVIATIONS: miRNA, microRNA; Limk1, lim-domain containing protein kinase 1.
- Received September 17, 2008.
- Accepted November 12, 2008.
- The American Society for Pharmacology and Experimental Therapeutics
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