Table of Contents

Articles

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  Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H₁-Receptor Compared with the Guinea Pig H₁-Receptor

  Andrea Straßer, Hans-Joachim Wittmann, Marc Kunze, Sigurd Elz and Roland Seifert

  Molecular Pharmacology March 2009, 75 (3) 454-465; DOI: https://doi.org/10.1124/mol.108.053009
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  Canonical Transient Receptor Potential Channel (TRPC) 3 and TRPC6 Associate with Large-Conductance Ca²⁺-Activated K⁺ (BK_Ca) Channels: Role in BK_Ca Trafficking to the Surface of Cultured Podocytes

  Eun Young Kim, Claudia P. Alvarez-Baron and Stuart E. Dryer

  Molecular Pharmacology March 2009, 75 (3) 466-477; DOI: https://doi.org/10.1124/mol.108.051912
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  Cu/Zn Superoxide Dismutase Typical for Familial Amyotrophic Lateral Sclerosis Increases the Vulnerability of Mitochondria and Perturbs Ca²⁺ Homeostasis in SOD1^G93A Mice

  Manoj Kumar Jaiswal and Bernhard U. Keller

  Molecular Pharmacology March 2009, 75 (3) 478-489; DOI: https://doi.org/10.1124/mol.108.050831
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  The Relative Activity of “Function Sparing” HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property?

  Vanessa M. Muniz-Medina, Stacey Jones, Jodi M. Maglich, Cristin Galardi, Robert E. Hollingsworth, Wieslaw M. Kazmierski, Robert G. Ferris, Mark P. Edelstein, Karen E. Chiswell and Terry P. Kenakin

  Molecular Pharmacology March 2009, 75 (3) 490-501; DOI: https://doi.org/10.1124/mol.108.052555
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  Evidence for a Direct and Functional Interaction between the Regulators of G Protein Signaling-2 and Phosphorylated C Terminus of Cholecystokinin-2 Receptor

  Ingrid Langer, Irina G. Tikhonova, Cyril Boulègue, Jean-Pierre Estève, Sébastien Vatinel, Audrey Ferrand, Luis Moroder, Patrick Robberecht and Daniel Fourmy

  Molecular Pharmacology March 2009, 75 (3) 502-513; DOI: https://doi.org/10.1124/mol.108.051607
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  A Juxtamembrane Mutation in the N Terminus of the Dopamine Transporter Induces Preference for an Inward-Facing Conformation

  Bipasha Guptaroy, Minjia Zhang, Erica Bowton, Francesca Binda, Lei Shi, Harel Weinstein, Aurelio Galli, Jonathan A. Javitch, Richard R. Neubig and Margaret E. Gnegy

  Molecular Pharmacology March 2009, 75 (3) 514-524; DOI: https://doi.org/10.1124/mol.108.048744
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  Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1

  Manoj K. Pandey, Bokyung Sung, Kwang Seok Ahn and Bharat B. Aggarwal

  Molecular Pharmacology March 2009, 75 (3) 525-533; DOI: https://doi.org/10.1124/mol.108.052548
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  Fluorescence Resonance Energy Transfer Analysis of α_2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes

  A. Zürn, U. Zabel, J.-P. Vilardaga, H. Schindelin, M. J. Lohse and C. Hoffmann

  Molecular Pharmacology March 2009, 75 (3) 534-541; DOI: https://doi.org/10.1124/mol.108.052399
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  Mechanisms and Functional Significance of Inhibition of Neuronal T-Type Calcium Channels by Isoflurane

  Peihan Orestes, Damir Bojadzic, Robert M. Chow and Slobodan M. Todorovic

  Molecular Pharmacology March 2009, 75 (3) 542-554; DOI: https://doi.org/10.1124/mol.108.051664
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  Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

  Hongbin Dong, Timothy P. Dalton, Marian L. Miller, Ying Chen, Shigeyuki Uno, Zhanquan Shi, Howard G. Shertzer, Seema Bansal, Narayan G. Avadhani and Daniel W. Nebert

  Molecular Pharmacology March 2009, 75 (3) 555-567; DOI: https://doi.org/10.1124/mol.108.051888
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  Analysis of DNA Methylation and Histone Modification Profiles of Liver-Specific Transporters

  Satoki Imai, Ryota Kikuchi, Hiroyuki Kusuhara, Shintaro Yagi, Kunio Shiota and Yuichi Sugiyama

  Molecular Pharmacology March 2009, 75 (3) 568-576; DOI: https://doi.org/10.1124/mol.108.052589
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  Discovery and Characterization of Novel Allosteric Potentiators of M₁ Muscarinic Receptors Reveals Multiple Modes of Activity

  Joy E. Marlo, Colleen M. Niswender, Emily L. Days, Thomas M. Bridges, Yun Xiang, Alice L. Rodriguez, Jana K. Shirey, Ashley E. Brady, Tasha Nalywajko, Qingwei Luo, Cheryl A. Austin, Michael Baxter Williams, Kwangho Kim, Richard Williams, Darren Orton, H. Alex Brown, Craig W. Lindsley, C. David Weaver and P. Jeffrey Conn

  Molecular Pharmacology March 2009, 75 (3) 577-588; DOI: https://doi.org/10.1124/mol.108.052886
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  Identification of an Activator Protein-1-Like Sequence as the Glucocorticoid Response Element in the Rat Tyrosine Hydroxylase Gene

  C. S. Sheela Rani, Narayanasamy Elango, Shou-shu Wang, Kazuto Kobayashi and Randy Strong

  Molecular Pharmacology March 2009, 75 (3) 589-598; DOI: https://doi.org/10.1124/mol.108.051219
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  Psoralen-Induced DNA Interstrand Cross-Links Block Transcription and Induce p53 in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner

  Frederick A. Derheimer, J. Kevin Hicks, Michelle T. Paulsen, Christine E. Canman and Mats Ljungman

  Molecular Pharmacology March 2009, 75 (3) 599-607; DOI: https://doi.org/10.1124/mol.108.051698
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  Phospholipase C-Mediated Regulation of Transient Receptor Potential Vanilloid 6 Channels: Implications in Active Intestinal Ca²⁺ Transport

  Baskaran Thyagarajan, Bryan S. Benn, Sylvia Christakos and Tibor Rohacs

  Molecular Pharmacology March 2009, 75 (3) 608-616; DOI: https://doi.org/10.1124/mol.108.052449
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  Synthetic Small-Molecule Prohormone Convertase 2 Inhibitors

  Dorota Kowalska, Jin Liu, Jon R. Appel, Akihiko Ozawa, Adel Nefzi, Robert B. Mackin, Richard A. Houghten and Iris Lindberg

  Molecular Pharmacology March 2009, 75 (3) 617-625; DOI: https://doi.org/10.1124/mol.108.051334
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  Reciprocal Regulation of the Platelet-Derived Growth Factor Receptor-β and G Protein-Coupled Receptor Kinase 5 by Cross-Phosphorylation: Effects on Catalysis

  Xinjiang Cai, Jiao-Hui Wu, Sabrina T. Exum, Martin Oppermann, Richard T. Premont, Sudha K. Shenoy and Neil J. Freedman

  Molecular Pharmacology March 2009, 75 (3) 626-636; DOI: https://doi.org/10.1124/mol.108.050278
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  Differential Coupling of the Vasopressin V_1b Receptor through Compartmentalization within the Plasma Membrane

  Hélène Orcel, Laura Albizu, Sanja Perkovska, Thierry Durroux, Christiane Mendre, Hervé Ansanay, Bernard Mouillac and Alain Rabié

  Molecular Pharmacology March 2009, 75 (3) 637-647; DOI: https://doi.org/10.1124/mol.108.049031
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  Molecular Mechanisms of Corticotropin-Releasing Factor Receptor-Induced Calcium Signaling

  Eric Gutknecht, Ilse Van der Linden, Kristof Van Kolen, Kim F. C. Verhoeven, Georges Vauquelin and Frank M. Dautzenberg

  Molecular Pharmacology March 2009, 75 (3) 648-657; DOI: https://doi.org/10.1124/mol.108.050427
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  Quantification of Focal Adhesion Kinase Activation Loop Phosphorylation as a Biomarker of Src Activity

  Eugene Ciccimaro, Steven K. Hanks and Ian A. Blair

  Molecular Pharmacology March 2009, 75 (3) 658-666; DOI: https://doi.org/10.1124/mol.108.052464
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  Heterocyclic Thioureylenes Protect from Calcium-Dependent Neuronal Cell Death

  Matjaz Humar, Christine Graetz, Martin Roesslein, Ulrich Goebel, Klaus K. Geiger, Bernd Heimrich and Benedikt H. J. Pannen

  Molecular Pharmacology March 2009, 75 (3) 667-676; DOI: https://doi.org/10.1124/mol.108.052183
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  Unveiling a New Essential Cis Element for the Transactivation of the CYP3A4 Gene by Xenobiotics

  Takayoshi Toriyabe, Kiyoshi Nagata, Tomonari Takada, Yusuke Aratsu, Tsutomu Matsubara, Kouichi Yoshinari and Yasushi Yamazoe

  Molecular Pharmacology March 2009, 75 (3) 677-684; DOI: https://doi.org/10.1124/mol.108.050575
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  Angiotensin-Converting Enzyme (ACE) Inhibitors Modulate Cellular Retinol-Binding Protein 1 and Adiponectin Expression in Adipocytes via the ACE-Dependent Signaling Cascade

  Karin Kohlstedt, Cynthia Gershome, Caroline Trouvain, Wolf-Karsten Hofmann, Stephan Fichtlscherer and Ingrid Fleming

  Molecular Pharmacology March 2009, 75 (3) 685-692; DOI: https://doi.org/10.1124/mol.108.051631
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  Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2′(3′)-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

  Hesham M. Taha, Jennifer Schmidt, Martin Göttle, Srividya Suryanarayana, Yuequan Shen, Wei-Jen Tang, Andreas Gille, Jens Geduhn, Burkhard König, Stefan Dove and Roland Seifert

  Molecular Pharmacology March 2009, 75 (3) 693-703; DOI: https://doi.org/10.1124/mol.108.052340
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  Desipramine Reduces Stress-Activated Dynorphin Expression and CREB Phosphorylation in NAc Tissue

  Elena H. Chartoff, Maria Papadopoulou, Matt L. MacDonald, Aram Parsegian, David Potter, Christine Konradi and William A. Carlezon

  Molecular Pharmacology March 2009, 75 (3) 704-712; DOI: https://doi.org/10.1124/mol.108.051417
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  Facilitatory Interplay in α_1a and β₂ Adrenoceptor Function Reveals a Non-G_q Signaling Mode: Implications for Diversification of Intracellular Signal Transduction

  Alicja J. Copik, Cynthia Ma, Alan Kosaka, Sunil Sahdeo, Andy Trane, Hoangdung Ho, Paul S. Dietrich, Helen Yu, Anthony P. D. W. Ford, Donald Button and Marcos E. Milla

  Molecular Pharmacology March 2009, 75 (3) 713-728; DOI: https://doi.org/10.1124/mol.108.050765