Table of Contents

Articles

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  Anterograde Trafficking of G Protein-Coupled Receptors: Function of the C-Terminal F(X)₆LL Motif in Export from the Endoplasmic Reticulum

  Matthew T. Duvernay, Chunmin Dong, Xiaoping Zhang, Fuguo Zhou, Charles D. Nichols and Guangyu Wu

  Molecular Pharmacology April 2009, 75 (4) 751-761; DOI: https://doi.org/10.1124/mol.108.051623
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  Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

  M. W. Pennington, C. Beeton, C. A. Galea, B. J. Smith, V. Chi, K. P. Monaghan, A. Garcia, S. Rangaraju, A. Giuffrida, D. Plank, G. Crossley, D. Nugent, I. Khaytin, Y. LeFievre, I. Peshenko, C. Dixon, S. Chauhan, A. Orzel, T. Inoue, X. Hu, R. V. Moore, R. S. Norton and K. G. Chandy

  Molecular Pharmacology April 2009, 75 (4) 762-773; DOI: https://doi.org/10.1124/mol.108.052704
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  Activation of (Na⁺+K⁺)-ATPase Modulates Cardiac L-Type Ca²⁺ Channel Function

  Dong I. Lee, Michael G. Klein, Weizhong Zhu, Rui-Ping Xiao, Volodymyr Gerzanich and Kai Y. Xu

  Molecular Pharmacology April 2009, 75 (4) 774-781; DOI: https://doi.org/10.1124/mol.108.052597
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  Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor α-Independent Mechanism

  Takero Nakajima, Naoki Tanaka, Hiroki Kanbe, Atsushi Hara, Yuji Kamijo, Xiaowei Zhang, Frank J. Gonzalez and Toshifumi Aoyama

  Molecular Pharmacology April 2009, 75 (4) 782-792; DOI: https://doi.org/10.1124/mol.108.052928
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  Alanine Scanning Mutagenesis of the Second Extracellular Loop of Type 1 Corticotropin-Releasing Factor Receptor Revealed Residues Critical for Peptide Binding

  Kostas Gkountelias, Theodoros Tselios, Maria Venihaki, George Deraos, Iakovos Lazaridis, Olga Rassouli, Achille Gravanis and George Liapakis

  Molecular Pharmacology April 2009, 75 (4) 793-800; DOI: https://doi.org/10.1124/mol.108.052423
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  The Sequence after the Signal Peptide of the G Protein-Coupled Endothelin B Receptor Is Required for Efficient Translocon Gating at the Endoplasmic Reticulum Membrane

  Martina Alken, Antje Schmidt, Claudia Rutz, Jens Furkert, Gunnar Kleinau, Walter Rosenthal and Ralf Schülein

  Molecular Pharmacology April 2009, 75 (4) 801-811; DOI: https://doi.org/10.1124/mol.108.051581
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  A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor-κB Pathway

  Wenbo Zhu, Yanqiu Ou, Yan Li, Ru Xiao, Minfeng Shu, Yuehan Zhou, Jun Xie, Songmin He, Pengxin Qiu and Guangmei Yan

  Molecular Pharmacology April 2009, 75 (4) 812-819; DOI: https://doi.org/10.1124/mol.108.052605
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  Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

  Thomas E. Taylor-Clark, Srinivas Ghatta, Weston Bettner and Bradley J. Undem

  Molecular Pharmacology April 2009, 75 (4) 820-829; DOI: https://doi.org/10.1124/mol.108.054445
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  Capacitative Ca²⁺ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

  Agnes C. L. Martin, Debbie Willoughby, Antonio Ciruela, Laura-Jo Ayling, Mario Pagano, Sebastian Wachten, Anders Tengholm and Dermot M. F. Cooper

  Molecular Pharmacology April 2009, 75 (4) 830-842; DOI: https://doi.org/10.1124/mol.108.051748
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  Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers

  Christopher H. So, Vaneeta Verma, Mohammad Alijaniaram, Regina Cheng, Asim J. Rashid, Brian F. O'Dowd and Susan R. George

  Molecular Pharmacology April 2009, 75 (4) 843-854; DOI: https://doi.org/10.1124/mol.108.051805
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  The 27-kDa Heat Shock Protein Confers Cytoprotective Effects through a β2-Adrenergic Receptor Agonist-Initiated Complex with β-Arrestin

  Lalida Rojanathammanee, Erin B. Harmon, Laurel A. Grisanti, Piyarat Govitrapong, Manuchair Ebadi, Bryon D. Grove, Masaru Miyagi and James E. Porter

  Molecular Pharmacology April 2009, 75 (4) 855-865; DOI: https://doi.org/10.1124/mol.108.053397
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  Sphingolipids Function as Downstream Effectors of a Fungal PAQR

  Nancy Y. Villa, Brian R. Kupchak, Ibon Garitaonandia, Jessica L. Smith, Emilio Alonso, Charlene Alford, L. Ashley Cowart, Yusuf A. Hannun and Thomas J. Lyons

  Molecular Pharmacology April 2009, 75 (4) 866-875; DOI: https://doi.org/10.1124/mol.108.049809
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  Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

  Koen van de Wetering, Alexander Burkon, Wouter Feddema, Alice Bot, Hugo de Jonge, Veronika Somoza and Piet Borst

  Molecular Pharmacology April 2009, 75 (4) 876-885; DOI: https://doi.org/10.1124/mol.108.052019
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  Inactivation of Soluble Guanylate Cyclase by Stoichiometric S-Nitrosation

  Bernd Mayer, Andrei L. Kleschyov, Heike Stessel, Michael Russwurm, Thomas Münzel, Doris Koesling and Kurt Schmidt

  Molecular Pharmacology April 2009, 75 (4) 886-891; DOI: https://doi.org/10.1124/mol.108.052142
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  Modulation of Excitatory Synaptic Transmission by Δ⁹-Tetrahydrocannabinol Switches from Agonist to Antagonist Depending on Firing Rate

  Alan M. Roloff and Stanley A. Thayer

  Molecular Pharmacology April 2009, 75 (4) 892-900; DOI: https://doi.org/10.1124/mol.108.051482
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  An Acyl-Ghrelin-Specific Neutralizing Antibody Inhibits the Acute Ghrelin-Mediated Orexigenic Effects in Mice

  Shu-Chen Lu, Jing Xu, Narumol Chinookoswong, Shuying Liu, Shirley Steavenson, Colin Gegg, David Brankow, Richard Lindberg, Murielle Véniant and Wei Gu

  Molecular Pharmacology April 2009, 75 (4) 901-907; DOI: https://doi.org/10.1124/mol.108.052852
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  Direct Subunit-Dependent Multimodal 5-Hydroxytryptamine₃ Receptor Antagonism by Methadone

  Tarek Z. Deeb, Douglas Sharp and Tim G. Hales

  Molecular Pharmacology April 2009, 75 (4) 908-917; DOI: https://doi.org/10.1124/mol.108.053322
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  Acetylcholine-Stimulated [³H]GABA Release from Mouse Brain Synaptosomes is Modulated by α4β2 and α4α5β2 Nicotinic Receptor Subtypes

  Tristan D. McClure-Begley, Nathan M. King, Allan C. Collins, Jerry A. Stitzel, Jeanne M. Wehner and Christopher M. Butt

  Molecular Pharmacology April 2009, 75 (4) 918-926; DOI: https://doi.org/10.1124/mol.108.052274
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  Intracellular Potassium Stabilizes Human Ether-à-go-go-Related Gene Channels for Export from Endoplasmic Reticulum

  Lu Wang, Adrienne T. Dennis, Phan Trieu, Francois Charron, Natalie Ethier, Terence E. Hebert, Xiaoping Wan and Eckhard Ficker

  Molecular Pharmacology April 2009, 75 (4) 927-937; DOI: https://doi.org/10.1124/mol.108.053793
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  Prominent Role of α3/α6β2^* nAChRs in Regulating Evoked Dopamine Release in Primate Putamen: Effect of Long-Term Nicotine Treatment

  Xiomara A. Perez, Kathryn T. O'Leary, Neeraja Parameswaran, J. Michael McIntosh and Maryka Quik

  Molecular Pharmacology April 2009, 75 (4) 938-946; DOI: https://doi.org/10.1124/mol.108.053801
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  Cross-Talk between Integrins and Oncogenes Modulates Chemosensitivity

  Jordi Carreras Puigvert, Stephan Huveneers, Lisa Fredriksson, Marieke op het Veld, Bob van de Water and Erik H. J. Danen

  Molecular Pharmacology April 2009, 75 (4) 947-955; DOI: https://doi.org/10.1124/mol.108.051649
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  Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction

  Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Arief Nurrochmad, Yuji Ito, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri and Hideyuki Yamada

  Molecular Pharmacology April 2009, 75 (4) 956-964; DOI: https://doi.org/10.1124/mol.108.052001
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  A Cytochrome P450-Derived Epoxygenated Metabolite of Anandamide Is a Potent Cannabinoid Receptor 2-Selective Agonist

  Natasha T. Snider, James A. Nast, Laura A. Tesmer and Paul F. Hollenberg

  Molecular Pharmacology April 2009, 75 (4) 965-972; DOI: https://doi.org/10.1124/mol.108.053439
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  Steroid Interaction with a Single Potentiating Site Is Sufficient to Modulate GABA-A Receptor Function

  John R. Bracamontes and Joe Henry Steinbach

  Molecular Pharmacology April 2009, 75 (4) 973-981; DOI: https://doi.org/10.1124/mol.108.053629
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  Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors

  Lucie P. Pellissier, Jessica Sallander, Mercedes Campillo, Florence Gaven, Emilie Queffeulou, Marion Pillot, Aline Dumuis, Sylvie Claeysen, Joël Bockaert and Leonardo Pardo

  Molecular Pharmacology April 2009, 75 (4) 982-990; DOI: https://doi.org/10.1124/mol.108.053686
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  Regulation of Group II Metabotropic Glutamate Receptors by G Protein-Coupled Receptor Kinases: mGlu2 Receptors Are Resistant to Homologous Desensitization

  L. Iacovelli, G. Molinaro, G. Battaglia, M. Motolese, L. Di Menna, M. Alfiero, J. Blahos, F. Matrisciano, M. Corsi, C. Corti, V. Bruno, A. De Blasi and F. Nicoletti

  Molecular Pharmacology April 2009, 75 (4) 991-1003; DOI: https://doi.org/10.1124/mol.108.052316