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Research ArticleArticle

Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor α-Independent Mechanism

Takero Nakajima, Naoki Tanaka, Hiroki Kanbe, Atsushi Hara, Yuji Kamijo, Xiaowei Zhang, Frank J. Gonzalez and Toshifumi Aoyama
Molecular Pharmacology April 2009, 75 (4) 782-792; DOI: https://doi.org/10.1124/mol.108.052928
Takero Nakajima
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Naoki Tanaka
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Hiroki Kanbe
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Atsushi Hara
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Yuji Kamijo
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Xiaowei Zhang
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Frank J. Gonzalez
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Toshifumi Aoyama
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Article Information

vol. 75 no. 4 782-792
DOI 
https://doi.org/10.1124/mol.108.052928
PubMed 
19124612

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 20, 2008
  • Accepted January 5, 2009
  • Published online March 18, 2009.

Article Versions

  • Earlier version (January 5, 2009 - 09:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Takero Nakajima,
  2. Naoki Tanaka,
  3. Hiroki Kanbe,
  4. Atsushi Hara,
  5. Yuji Kamijo,
  6. Xiaowei Zhang,
  7. Frank J. Gonzalez and
  8. Toshifumi Aoyama
  1. Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan (T.N., N.T., H.K., A.H., Y.K., X.Z., T.A.); Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan (N.T., Y.K.); and Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland (F.J.G.)
  1. Address correspondence to:
    Dr. Naoki Tanaka, Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. E-mail: naopi{at}shinshu-u.ac.jp
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Molecular Pharmacology: 75 (4)
Molecular Pharmacology
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1 Apr 2009
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Research ArticleArticle

Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor α-Independent Mechanism

Takero Nakajima, Naoki Tanaka, Hiroki Kanbe, Atsushi Hara, Yuji Kamijo, Xiaowei Zhang, Frank J. Gonzalez and Toshifumi Aoyama
Molecular Pharmacology April 1, 2009, 75 (4) 782-792; DOI: https://doi.org/10.1124/mol.108.052928

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Research ArticleArticle

Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor α-Independent Mechanism

Takero Nakajima, Naoki Tanaka, Hiroki Kanbe, Atsushi Hara, Yuji Kamijo, Xiaowei Zhang, Frank J. Gonzalez and Toshifumi Aoyama
Molecular Pharmacology April 1, 2009, 75 (4) 782-792; DOI: https://doi.org/10.1124/mol.108.052928
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