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Molecular Pharmacology

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Table of Contents

June 01, 2009; Volume 75,Issue 6

MINIREVIEWS

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    Targeting Protein Serine/Threonine Phosphatases for Drug Development
    Jamie L. McConnell and Brian E. Wadzinski
    Molecular Pharmacology June 2009, 75 (6) 1249-1261; DOI: https://doi.org/10.1124/mol.108.053140
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    Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
    Joris Vriens, Giovanni Appendino and Bernd Nilius
    Molecular Pharmacology June 2009, 75 (6) 1262-1279; DOI: https://doi.org/10.1124/mol.109.055624

Accelerated Communication

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    Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin
    Masahiro Tsuda, Tomohiro Terada, Tomoyuki Mizuno, Toshiya Katsura, Jin Shimakura and Ken-ichi Inui
    Molecular Pharmacology June 2009, 75 (6) 1280-1286; DOI: https://doi.org/10.1124/mol.109.056242

Articles

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    Mutational and In Silico Analyses for Antidepressant Block of Astroglial Inward-Rectifier Kir4.1 Channel
    Kazuharu Furutani, Yukihiro Ohno, Atsushi Inanobe, Hiroshi Hibino and Yoshihisa Kurachi
    Molecular Pharmacology June 2009, 75 (6) 1287-1295; DOI: https://doi.org/10.1124/mol.108.052936
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    Instability of a Class A G Protein-Coupled Receptor Oligomer Interface
    Jacqueline M. Fonseca and Nevin A. Lambert
    Molecular Pharmacology June 2009, 75 (6) 1296-1299; DOI: https://doi.org/10.1124/mol.108.053876
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    Activation of Rho and Rho-Associated Kinase by GPR54 and KiSS1 Metastasis Suppressor Gene Product Induces Changes of Cell Morphology and Contributes to Apoptosis
    Jean-Marc Navenot, Nobutaka Fujii and Stephen C. Peiper
    Molecular Pharmacology June 2009, 75 (6) 1300-1306; DOI: https://doi.org/10.1124/mol.109.055095
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    μ-Opioid Receptor Cell Surface Expression Is Regulated by Its Direct Interaction with Ribophorin I
    Xin Ge, Horace H. Loh and Ping-Yee Law
    Molecular Pharmacology June 2009, 75 (6) 1307-1316; DOI: https://doi.org/10.1124/mol.108.054064
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    Met909 Plays a Key Role in the Activation of the Progesterone Receptor and Also in the High Potency of 13-Ethyl Progestins
    Isabelle Petit-Topin, Nathalie Turque, Jérôme Fagart, Michel Fay, André Ulmann, Erin Gainer and Marie-Edith Rafestin-Oblin
    Molecular Pharmacology June 2009, 75 (6) 1317-1324; DOI: https://doi.org/10.1124/mol.108.054312
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    Elucidation of Binding Sites of Dual Antagonists in the Human Chemokine Receptors CCR2 and CCR5
    Spencer E. Hall, Allen Mao, Vicky Nicolaidou, Mattea Finelli, Emma L. Wise, Belinda Nedjai, Julie Kanjanapangka, Paymann Harirchian, Deborah Chen, Victor Selchau, Sofia Ribeiro, Sabine Schyler, James E. Pease, Richard Horuk and Nagarajan Vaidehi
    Molecular Pharmacology June 2009, 75 (6) 1325-1336; DOI: https://doi.org/10.1124/mol.108.053470
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    CYP4F2 Is a Vitamin K1 Oxidase: An Explanation for Altered Warfarin Dose in Carriers of the V433M Variant
    Matthew G. McDonald, Mark J. Rieder, Mariko Nakano, Clara K. Hsia and Allan E. Rettie
    Molecular Pharmacology June 2009, 75 (6) 1337-1346; DOI: https://doi.org/10.1124/mol.109.054833
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    An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
    Samantha McCavera, Adrian T. Rogers, Darran M. Yates, Debra J. Woods and Adrian J. Wolstenholme
    Molecular Pharmacology June 2009, 75 (6) 1347-1355; DOI: https://doi.org/10.1124/mol.108.053363
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    Bifunctional DNA Alkylator 1,3-Bis(2-chloroethyl)-1-nitrosourea Activates the ATR-Chk1 Pathway Independently of the Mismatch Repair Pathway
    B. Cui, S. P. Johnson, N. Bullock, F. Ali-Osman, D. D. Bigner and H. S. Friedman
    Molecular Pharmacology June 2009, 75 (6) 1356-1363; DOI: https://doi.org/10.1124/mol.108.053124
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    Enhancement of Doxorubicin Cytotoxicity on Human Esophageal Squamous Cell Carcinoma Cells by Indomethacin and 4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via Inhibiting P-Glycoprotein Activity
    Le Yu, William Ka Kei Wu, Zhi Jie Li, Qi Cai Liu, Hai Tao Li, Ya Chun Wu and Chi Hin Cho
    Molecular Pharmacology June 2009, 75 (6) 1364-1373; DOI: https://doi.org/10.1124/mol.108.053546
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    MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells
    Yu-Zhuo Pan, Marilyn E. Morris and Ai-Ming Yu
    Molecular Pharmacology June 2009, 75 (6) 1374-1379; DOI: https://doi.org/10.1124/mol.108.054163
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    Evidence for Distinct Antagonist-Revealed Functional States of 5-Hydroxytryptamine2A Receptor Homodimers
    José Brea, Marián Castro, Jesús Giraldo, Juan F. López-Giménez, Juan Fernando Padín, Fátima Quintián, Maria Isabel Cadavid, Maria Teresa Vilaró, Guadalupe Mengod, Kelly A. Berg, William P. Clarke, Jean-Pierre Vilardaga, Graeme Milligan and Maria Isabel Loza
    Molecular Pharmacology June 2009, 75 (6) 1380-1391; DOI: https://doi.org/10.1124/mol.108.054395
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    Regulation of Human Vitamin D3 25-Hydroxylases in Dermal Fibroblasts and Prostate Cancer LNCaP Cells
    Maria Ellfolk, Maria Norlin, Katarina Gyllensten and Kjell Wikvall
    Molecular Pharmacology June 2009, 75 (6) 1392-1399; DOI: https://doi.org/10.1124/mol.108.053660
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    Activation and Modulation of Concatemeric GABA-A Receptors Expressed in Human Embryonic Kidney Cells
    Gustav Akk, Ping Li, John Bracamontes and Joe Henry Steinbach
    Molecular Pharmacology June 2009, 75 (6) 1400-1411; DOI: https://doi.org/10.1124/mol.108.054510
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    Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice
    Colin A. Flaveny, Iain A. Murray, Chris R. Chiaro and Gary H. Perdew
    Molecular Pharmacology June 2009, 75 (6) 1412-1420; DOI: https://doi.org/10.1124/mol.109.054825
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    Statin-Induced Liver Injury Involves Cross-Talk between Cholesterol and Selenoprotein Biosynthetic Pathways
    Andrea Kromer and Bernd Moosmann
    Molecular Pharmacology June 2009, 75 (6) 1421-1429; DOI: https://doi.org/10.1124/mol.108.053678
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    A Small-Molecule Modulator Interacts Directly with ΔPhe508-CFTR to Modify Its ATPase Activity and Conformational Stability
    Leigh Wellhauser, Patrick Kim Chiaw, Stan Pasyk, Canhui Li, Mohabir Ramjeesingh and Christine E. Bear
    Molecular Pharmacology June 2009, 75 (6) 1430-1438; DOI: https://doi.org/10.1124/mol.109.055608
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In this issue

Molecular Pharmacology: 75 (6)
Molecular Pharmacology
Vol. 75, Issue 6
1 Jun 2009
  • Table of Contents
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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