Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site

Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia (A.J.Y., E.B., P.D.); Physiological Sciences Program, University of Arizona, Tucson, Arizona (A.J.Y., E.M., J.S.F.); College of Pharmacy & BIO5 Institute, University of Arizona, Tucson, Arizona (N.M., G.F.); Chemogenomics Laboratory, Translational Genomics Research Institute (TGen), Phoenix, Arizona, and FRS-FNRS, Laboratoire de Physico-Chimie Informatique, University of Namur, Namur, Belgium (N.M.); and Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut (S.S.)

Address correspondence to:
Dr. Andrea Yool, Discipline of Physiology, School of Molecular and Biomedical Science, Med School South Level 4 Frome Road, University of Adelaide, Adelaide SA 5005, Australia. E-mail: andrea.yool{at}adelaide.edu.au

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