Molecular Pharmacology: 76 (2)

August 01, 2009; Volume 76,Issue 2

CENTENNIAL PERSPECTIVE

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Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
David J. Waxman and Minita G. Holloway

Molecular Pharmacology August 2009, 76 (2) 215-228; DOI: https://doi.org/10.1124/mol.109.056705

MINIREVIEWS

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Trace Amine-Associated Receptors as Emerging Therapeutic Targets
Tatyana D. Sotnikova, Marc G. Caron and Raul R. Gainetdinov

Molecular Pharmacology August 2009, 76 (2) 229-235; DOI: https://doi.org/10.1124/mol.109.055970
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Diphosphoinositol Polyphosphates: Metabolic Messengers?
Stephen B. Shears

Molecular Pharmacology August 2009, 76 (2) 236-252; DOI: https://doi.org/10.1124/mol.109.055897

Articles

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An Allosteric Modulator of α7 Nicotinic Receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), Causes Conformational Changes in the Extracellular Ligand Binding Domain Similar to Those Caused by Acetylcholine
Sean C. Barron, James T. McLaughlin, Jennifer A. See, Vanessa L. Richards and Robert L. Rosenberg

Molecular Pharmacology August 2009, 76 (2) 253-263; DOI: https://doi.org/10.1124/mol.109.056226
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Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor
Fan Gao, Kaleeckal G. Harikumar, Maoqing Dong, Polo C.-H. Lam, Patrick M. Sexton, Arthur Christopoulos, Andrew Bordner, Ruben Abagyan and Laurence J. Miller

Molecular Pharmacology August 2009, 76 (2) 264-274; DOI: https://doi.org/10.1124/mol.109.055756
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Five Amino Acids in the Innermost Cavity of the Substrate Binding Cleft of Organic Cation Transporter 1 Interact with Extracellular and Intracellular Corticosterone
Christopher Volk, Valentin Gorboulev, Alexander Kotzsch, Thomas D. Müller and Hermann Koepsell

Molecular Pharmacology August 2009, 76 (2) 275-289; DOI: https://doi.org/10.1124/mol.109.054783
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Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism
Nadia Lampiasi, Antonina Azzolina, Natale D'Alessandro, Kazuo Umezawa, James A. McCubrey, Giuseppe Montalto and Melchiorre Cervello

Molecular Pharmacology August 2009, 76 (2) 290-300; DOI: https://doi.org/10.1124/mol.109.055418
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Irreversible Platelet Activation Requires Protease-Activated Receptor 1-Mediated Signaling to Phosphatidylinositol Phosphates
Michael Holinstat, Anita M. Preininger, Stephen B. Milne, W. James Hudson, H. Alex Brown and Heidi E. Hamm

Molecular Pharmacology August 2009, 76 (2) 301-313; DOI: https://doi.org/10.1124/mol.109.056622
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α₁-Adrenergic Receptors Regulate Neurogenesis and Gliogenesis
Manveen K. Gupta, Robert S. Papay, Chris W. D. Jurgens, Robert J. Gaivin, Ting Shi, Van A. Doze and Dianne M. Perez

Molecular Pharmacology August 2009, 76 (2) 314-326; DOI: https://doi.org/10.1124/mol.109.057307
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BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing
Aditi Pandya Martin, Margaret A. Park, Clint Mitchell, Teneille Walker, Mohamed Rahmani, Andrew Thorburn, Dieter Häussinger, Roland Reinehr, Steven Grant and Paul Dent

Molecular Pharmacology August 2009, 76 (2) 327-341; DOI: https://doi.org/10.1124/mol.109.056309
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Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms
Teneille Walker, Clint Mitchell, Margaret A. Park, Adly Yacoub, Martin Graf, Mohamed Rahmani, Peter J. Houghton, Christina Voelkel-Johnson, Steven Grant and Paul Dent

Molecular Pharmacology August 2009, 76 (2) 342-355; DOI: https://doi.org/10.1124/mol.109.056523
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A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning
Douglas J. Sheffler, Richard Williams, Thomas M. Bridges, Zixiu Xiang, Alexander S. Kane, Nellie E. Byun, Satyawan Jadhav, Mathew M. Mock, Fang Zheng, L. Michelle Lewis, Carrie K. Jones, Colleen M. Niswender, Charles D. Weaver, Craig W. Lindsley and P. Jeffrey Conn

Molecular Pharmacology August 2009, 76 (2) 356-368; DOI: https://doi.org/10.1124/mol.109.056531
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Augmentation of Fear Extinction by Infusion of Glycine Transporter Blockers into the Amygdala
Sheng-Chun Mao, Hui-Ching Lin and Po-Wu Gean

Molecular Pharmacology August 2009, 76 (2) 369-378; DOI: https://doi.org/10.1124/mol.108.053728
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Activation of mGlu2/3 Metabotropic Glutamate Receptors Negatively Regulates the Stimulation of Inositol Phospholipid Hydrolysis Mediated by 5-Hydroxytryptamine_2A Serotonin Receptors in the Frontal Cortex of Living Mice
G. Molinaro, A. Traficante, B. Riozzi, L. Di Menna, M. Curto, S. Pallottino, F. Nicoletti, V. Bruno and G. Battaglia

Molecular Pharmacology August 2009, 76 (2) 379-387; DOI: https://doi.org/10.1124/mol.109.056580
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Cytosolic Aryl Sulfotransferase 4A1 Interacts with the Peptidyl Prolyl Cis-Trans Isomerase Pin1
Deanne J. Mitchell and Rodney F. Minchin

Molecular Pharmacology August 2009, 76 (2) 388-395; DOI: https://doi.org/10.1124/mol.109.055442
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Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum
Lifen Zhang, William M. Doyon, Jeremy J. Clark, Paul E. M. Phillips and John A. Dani

Molecular Pharmacology August 2009, 76 (2) 396-404; DOI: https://doi.org/10.1124/mol.109.056317
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Comparative Study of Inhibition at Multiple Stages of Amyloid-β Self-Assembly Provides Mechanistic Insight
Timothy J. Davis, Deborah D. Soto-Ortega, Joseph A. Kotarek, Francisco J. Gonzalez-Velasquez, Krishnamoothy Sivakumar, Laying Wu, Qian Wang and Melissa A. Moss

Molecular Pharmacology August 2009, 76 (2) 405-413; DOI: https://doi.org/10.1124/mol.109.055301
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Peroxisome Proliferator-Activated Receptor (PPAR)-γ Positively Controls and PPARα Negatively Controls Cyclooxygenase-2 Expression in Rat Brain Astrocytes through a Convergence on PPARβ/δ via Mutual Control of PPAR Expression Levels
Stepan Aleshin, Sevil Grabeklis, Theodor Hanck, Marina Sergeeva and Georg Reiser

Molecular Pharmacology August 2009, 76 (2) 414-424; DOI: https://doi.org/10.1124/mol.109.056010
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Estrogen Receptor α, Fos-Related Antigen-2, and c-Jun Coordinately Regulate Human UDP Glucuronosyltransferase 2B15 and 2B17 Expression in Response to 17β-Estradiol in MCF-7 Cells
Dong Gui Hu and Peter I. Mackenzie

Molecular Pharmacology August 2009, 76 (2) 425-439; DOI: https://doi.org/10.1124/mol.109.057380
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Docking of 1,4-Benzodiazepines in the α₁/γ₂ GABA_A Receptor Modulator Site
D. Berezhnoy, T. T. Gibbs and D. H. Farb

Molecular Pharmacology August 2009, 76 (2) 440-450; DOI: https://doi.org/10.1124/mol.109.054650

Errata

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Correction to “Mutational and in Silico Analyses for Antidepressant Block of Astroglial Inward-Rectifier Kir4.1 Channel”
Molecular Pharmacology August 2009, 76 (2) 451; DOI: https://doi.org/10.1124/mol.76.2.451
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Correction to “Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle”
Molecular Pharmacology August 2009, 76 (2) 452; DOI: https://doi.org/10.1124/mol.76.2.452

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