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Molecular Pharmacology

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Research ArticleArticle

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

Lifen Zhang, William M. Doyon, Jeremy J. Clark, Paul E. M. Phillips and John A. Dani
Molecular Pharmacology August 2009, 76 (2) 396-404; DOI: https://doi.org/10.1124/mol.109.056317
Lifen Zhang
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William M. Doyon
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Jeremy J. Clark
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Paul E. M. Phillips
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John A. Dani
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Abstract

Dopamine (DA) release varies within subregions and local environments of the striatum, suggesting that controls intrinsic and extrinsic to the DA fibers and terminals regulate release. While applying fast-scan cyclic voltammetry and using tonic and phasic stimulus trains, we investigated the regulation of DA release in the dorsolateral to ventral striatum. The ratio of phasic-to-tonic-evoked DA signals varied with the average ongoing firing frequency, and the ratio was generally higher in the nucleus accumbens (NAc) compared with the dorsolateral striatum. At the normal average firing frequency, burst stimulation produces a larger increase in the DA response in the NAc than the dorsolateral striatum. This finding was comparable whether the DA measurements were made using in vitro brain slices or were recorded in vivo from freely moving rodents. Blockade of the dopamine transporters and dopamine D2 receptors particularly enhanced the tonic DA signals. Conversely, blockade of nicotinic acetylcholine receptors (nAChRs) containing the β2 subunit (β2*) predominantly suppressed tonic DA signals. The suppression of tonic DA release increased the contrast between phasic and tonic DA signals, and that made the frequency-dependent DA dynamics between the dorsolateral striatum and NAc more similar. The results indicate that intrinsic differences in the DA fibers that innervate specific regions of the striatum combine with (at least) DA transporters, DA receptors, and nAChRs to regulate the frequency dependence of DA release. A combination of mechanisms provides specific local control of DA release that underlies pathway-specific information associated with motor and reward-related functions.

Footnotes

  • This research was supported by grants from the National Institutes of Health National Institute on Drug Abuse [Grant DA009411]; the National Institutes of Health National Institute of Neurological Disorders and Stroke [Grant NS021229]; a National Research Service Award [F32-DA024540]; and the Diana Helis Henry Medical Research Foundation Parkinson's Disease Program.

  • ABBREVIATIONS: DA, dopamine; β2*, β2 subunit-containing; DAT, dopamine transporter; DHβE, dihydro-β-erythroidine; nAChR, nicotinic acetylcholine receptor; NAc, nucleus accumbens; SNc, substantia nigra pars compacta; VTA, ventral tegmental area; GBR, GBR 12909, piperazine, 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)-, dihydrochloride; 1p, single-pulse stimulus; 5p, stimulus train of five pulses; 20p, stimulus train of 20 pulses.

  • ↵ Embedded Image The online version of this article (available at http://molpharm.aspetjournals.org) contains supplemental material.

    • Accepted May 21, 2009.
    • Received March 18, 2009.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 76 (2)
Molecular Pharmacology
Vol. 76, Issue 2
1 Aug 2009
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Research ArticleArticle

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

Lifen Zhang, William M. Doyon, Jeremy J. Clark, Paul E. M. Phillips and John A. Dani
Molecular Pharmacology August 1, 2009, 76 (2) 396-404; DOI: https://doi.org/10.1124/mol.109.056317

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Research ArticleArticle

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

Lifen Zhang, William M. Doyon, Jeremy J. Clark, Paul E. M. Phillips and John A. Dani
Molecular Pharmacology August 1, 2009, 76 (2) 396-404; DOI: https://doi.org/10.1124/mol.109.056317
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